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ZAP1

YJL056C, ZRG10

View at SGD ↗

Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains

01 / RECOMMENDED MATRIX

Best-performing DNA-binding model.

RecommendedSource: Harbison et. al.
Fisher’s P-value7.49e-14
Information content22.6
Max PWM score17.5
Recommended cutoff14.96
View and copy the recommended matrices ↘
Position frequency matrix (PFM)
A | 0.999 0.001 0.001 0.001 0.001 0.400 0.999 0.999 0.001 0.001 0.001 0.065 0.400 0.001 
C | 0.001 0.999 0.999 0.799 0.001 0.400 0.001 0.001 0.001 0.001 0.001 0.235 0.200 0.001 
G | 0.001 0.001 0.001 0.001 0.001 0.001 0.001 0.001 0.999 0.999 0.001 0.035 0.400 0.001 
T | 0.001 0.001 0.001 0.200 0.999 0.200 0.001 0.001 0.001 0.001 0.999 0.664 0.001 0.999 
Position count matrix (PCM)
A |  99   0   0   0   0  40  99  99   0   0   0   6  40   0 
C |   0  99  99  79   0  40   0   0   0   0   0  23  20   0 
G |   0   0   0   0   0   0   0   0  99  99   0   3  40   0 
T |   0   0   0  20  99  20   0   0   0   0  99  66   0  99 
Position weight matrix (PWM)
A |  1.14 -5.77 -5.77 -5.77 -5.77  0.22  1.14  1.14 -5.77 -5.77 -5.77 -1.59  0.22 -5.77 
C | -5.19  1.71  1.71  1.49 -5.19  0.80 -5.19 -5.19 -5.19 -5.19 -5.19  0.27  0.11 -5.19 
G | -5.19 -5.19 -5.19 -5.19 -5.19 -5.19 -5.19 -5.19  1.71  1.71 -5.19 -1.64  0.80 -5.19 
T | -5.77 -5.77 -5.77 -0.47  1.14 -0.47 -5.77 -5.77 -5.77 -5.77  1.14  0.73 -5.77  1.14 
02 / COMPARATIVE BENCHMARKS

Alternative candidate matrices 2

Historical matrix candidates from the original ScerTF database. Expand a source to inspect its original logo, scores, and matrix values.

ZAP1Foat et. al.P = 3.12e-05View matrix ↘
Sequence logo for ZAP1
Fisher’s P-value3.12e-05
Information content16.26
Max PWM score16.81
Recommended cutoff9.47
Position frequency matrix (PFM)
A | 0.05 0.32 0.03 0.07 0.33 0.09 0.44 0.60 0.48 0.01 0.01 0.97 0.01 0.19 0.01 
C | 0.59 0.07 0.37 0.77 0.65 0.78 0.39 0.09 0.14 0.97 0.97 0.01 0.24 0.01 0.52 
G | 0.01 0.51 0.01 0.02 0.01 0.08 0.03 0.30 0.01 0.01 0.01 0.01 0.01 0.79 0.39 
T | 0.35 0.09 0.59 0.15 0.01 0.05 0.14 0.02 0.38 0.01 0.01 0.01 0.74 0.01 0.09 
Position count matrix (PCM)
A |   5  32   3   7  33   9  44  60  48   1   1  97   1  19   1 
C |  59   7  37  77  65  78  39   9  14  97  97   1  24   1  52 
G |   1  51   1   2   1   8   3  30   1   1   1   1   1  79  39 
T |  35   9  59  15   1   5  14   2  38   1   1   1  74   1   9 
Position weight matrix (PWM)
A | -1.86  0.00 -2.37 -1.52  0.03 -1.27  0.32  0.63  0.41 -3.47 -3.47  1.11 -3.47 -0.52 -3.47 
C |  1.19 -0.94  0.72  1.45  1.28  1.47  0.77 -0.69 -0.25  1.68  1.68 -2.89  0.29 -2.89  1.06 
G | -2.89  1.04 -2.89 -2.20 -2.89 -0.81 -1.79  0.51 -2.89 -2.89 -2.89 -2.89 -2.89  1.48  0.77 
T |  0.09 -1.27  0.61 -0.76 -3.47 -1.86 -0.83 -2.77  0.17 -3.47 -3.47 -3.47  0.84 -3.47 -1.27 
ZAP1Macisaac et. alP = 4.48e-13View matrix ↘
Sequence logo for ZAP1
Fisher’s P-value4.48e-13
Information content21.91
Max PWM score17.45
Recommended cutoff15.33
Position frequency matrix (PFM)
A | 0.997 0.001 0.001 0.001 0.001 0.642 0.997 0.714 0.001 0.001 0.001 0.143 0.714 0.071 0.285 
C | 0.001 0.997 0.997 0.356 0.001 0.286 0.001 0.071 0.001 0.001 0.001 0.357 0.001 0.071 0.001 
G | 0.001 0.001 0.001 0.001 0.001 0.071 0.001 0.214 0.997 0.997 0.001 0.143 0.214 0.001 0.713 
T | 0.001 0.001 0.001 0.642 0.997 0.001 0.001 0.001 0.001 0.001 0.997 0.357 0.071 0.857 0.001 
Position count matrix (PCM)
A |  99   0   0   0   0  64  99  71   0   0   0  14  71   7  28 
C |   0  99  99  35   0  28   0   7   0   0   0  35   0   7   0 
G |   0   0   0   0   0   7   0  21  99  99   0  14  21   0  71 
T |   0   0   0  64  99   0   0   0   0   0  99  35   7  85   0 
Position weight matrix (PWM)
A |  1.14 -5.77 -5.77 -5.77 -5.77  0.70  1.14  0.80 -5.77 -5.77 -5.77 -0.81  0.80 -1.51 -0.12 
C | -5.19  1.71  1.71  0.68 -5.19  0.46 -5.19 -0.93 -5.19 -5.19 -5.19  0.68 -5.19 -0.93 -5.19 
G | -5.19 -5.19 -5.19 -5.19 -5.19 -0.93 -5.19  0.17  1.71  1.71 -5.19 -0.23  0.17 -5.19  1.38 
T | -5.77 -5.77 -5.77  0.70  1.14 -5.77 -5.77 -5.77 -5.77 -5.77  1.14  0.11 -1.51  0.99 -5.77 
03 / EXPERIMENTAL CONTEXT

Gene-level annotations and interactions.

Genes bound in ChIP-chip experiments 69 genes

YAL001C, YBL109W, YBL111C, YBL112C, YBL113C, YBR048W, YBR254C, YBR255W, YCL065W, YCL066W, YCL067C, YCL068C, YCL074W, YCR039C, YCR040W, YCR041W, YCR105W, YDL044C, YDR042C, YDR064W, YDR065W, YDR066C, YDR098C, YDR526C, YDR543C, YEL012W, YER065C, YFL062W, YGL022W, YGL023C, YGL134W, YGL255W, YGR024C, YGR084C, YGR222W, YGR296W, YHR091C, YHR145C, YHR193C, YHR194W, YIL070C, YIL133C, YJL015C, YJL055W, YJL056C, YJL188C, YJL191W, YJL192C, YKL072W, YKL175W, YKL176C, YLR061W, YLR073C, YLR130C, YLR131C, YLR368W, YML065W, YML066C, YML132W, YML133C, YNL253W, YNL254C, YNL337W, YOL026C, YOL121C, YOL166C, YPL283C, YPR202W, YPR203W

Genes affected by TF deletion 60 genes

YHL012W, YPL207W, YMR040W, YPL240C, YKL073W, YKL104C, YPL016W, YKR103W, YGR032W, YMR315W, YGL181W, YML006C, YNL281W, YIL117C, YJR025C, YJR148W, YDR195W, YLR348C, YLR130C, YPL088W, YFL014W, YLR349W, YOL143C, YOR298C-A, YBR296C, YKR061W, YKR093W, YOL031C, YGL055W, YHR134W, YPR096C, YLR231C, YML130C, YNL064C, YOR080W, YPL061W, YJR130C, YKL001C, YOL156W, YLR355C, YNL160W, YOL119C, YHR018C, YIL170W, YJR104C, YDL124W, YJL079C, YLR453C, YMR184W, YOR027W, YGL255W, YIL101C, YMR062C, YMR034C, YNL104C, YLR049C, YLR423C, YNL234W, YAL029C, YFR030W

Genes supported by both experiments 2 genes

YGL255W, YLR130C