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YOX1

YML027W

View at SGD ↗

Homeodomain-containing transcriptional repressor, binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate

01 / RECOMMENDED MATRIX

Best-performing DNA-binding model.

RecommendedSource: Badis et. al.
Fisher’s P-value0.001885
Information content8.268
Max PWM score7.48
Recommended cutoff4.97
View and copy the recommended matrices ↘
Position frequency matrix (PFM)
A | 0.01 0.01 0.97 0.97 0.01 0.01 0.61 0.55 
C | 0.25 0.01 0.01 0.01 0.01 0.01 0.03 0.13 
G | 0.07 0.01 0.01 0.01 0.01 0.01 0.15 0.13 
T | 0.67 0.97 0.01 0.01 0.97 0.97 0.21 0.19 
Position count matrix (PCM)
A |   1   1  97  97   1   1  61  55 
C |  25   1   1   1   1   1   3  13 
G |   7   1   1   1   1   1  15  13 
T |  67  97   1   1  97  97  21  19 
Position weight matrix (PWM)
A | -3.47 -3.47  1.11  1.11 -3.47 -3.47  0.65  0.54 
C |  0.33 -2.89 -2.89 -2.89 -2.89 -2.89 -1.79 -0.33 
G | -0.94 -2.89 -2.89 -2.89 -2.89 -2.89 -0.18 -0.33 
T |  0.74  1.11 -3.47 -3.47  1.11  1.11 -0.42 -0.52 
02 / COMPARATIVE BENCHMARKS

Alternative candidate matrices 7

Historical matrix candidates from the original ScerTF database. Expand a source to inspect its original logo, scores, and matrix values.

YOX1Foat et. al.P = 7.89e-05View matrix ↘
Sequence logo for YOX1
Fisher’s P-value7.89e-05
Information content16.8
Max PWM score14.68
Recommended cutoff10.55
Position frequency matrix (PFM)
A | 0.01 0.13 0.96 0.01 0.01 0.01 0.01 0.01 0.65 0.01 0.03 0.43 0.97 
C | 0.25 0.85 0.02 0.52 0.97 0.01 0.01 0.55 0.01 0.01 0.02 0.56 0.01 
G | 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.44 0.03 0.04 0.01 0.01 0.01 
T | 0.74 0.01 0.01 0.47 0.01 0.97 0.97 0.01 0.31 0.94 0.94 0.01 0.01 
Position count matrix (PCM)
A |   1  13  96   1   1   1   1   1  65   1   3  43  97 
C |  25  85   2  52  97   1   1  55   1   1   2  56   1 
G |   1   1   1   1   1   1   1  44   3   4   1   1   1 
T |  74   1   1  47   1  97  97   1  31  94  94   1   1 
Position weight matrix (PWM)
A | -3.47 -0.90  1.10 -3.47 -3.47 -3.47 -3.47 -3.47  0.71 -3.47 -2.37  0.30  1.11 
C |  0.33  1.55 -2.20  1.06  1.68 -2.89 -2.89  1.12 -2.89 -2.89 -2.20  1.13 -2.89 
G | -2.89 -2.89 -2.89 -2.89 -2.89 -2.89 -2.89  0.89 -1.79 -1.50 -2.89 -2.89 -2.89 
T |  0.84 -3.47 -3.47  0.38 -3.47  1.11  1.11 -3.47 -0.03  1.08  1.08 -3.47 -3.47 
YOX1Harbison et. al.P = 2.97e-06View matrix ↘
Sequence logo for YOX1
Fisher’s P-value2.97e-06
Information content15
Max PWM score12.71
Recommended cutoff6.58
Position frequency matrix (PFM)
A | 0.964 0.012 0.964 0.964 0.012 0.964 0.250 0.012 0.012 0.964 0.488 0.488 
C | 0.012 0.488 0.012 0.012 0.012 0.012 0.250 0.012 0.012 0.012 0.488 0.012 
G | 0.012 0.488 0.012 0.012 0.012 0.012 0.250 0.012 0.965 0.012 0.012 0.488 
T | 0.012 0.012 0.012 0.012 0.964 0.012 0.250 0.964 0.012 0.012 0.012 0.012 
Position count matrix (PCM)
A |  96   1  96  96   1  96  25   1   1  96  48  48 
C |   1  48   1   1   1   1  25   1   1   1  48   1 
G |   1  48   1   1   1   1  25   1  96   1   1  48 
T |   1   1   1   1  96   1  25  96   1   1   1   1 
Position weight matrix (PWM)
A |  1.10 -3.28  1.10  1.10 -3.28  1.10 -0.25 -3.28 -3.28  1.10  0.42  0.42 
C | -2.71  1.00 -2.71 -2.71 -2.71 -2.71  0.33 -2.71 -2.71 -2.71  1.00 -2.71 
G | -2.71  1.00 -2.71 -2.71 -2.71 -2.71  0.33 -2.71  1.68 -2.71 -2.71  1.00 
T | -3.28 -3.28 -3.28 -3.28  1.10 -3.28 -0.25  1.10 -3.28 -3.28 -3.28 -3.28 
YOX1Macisaac et. alP = 4.33e-13View matrix ↘
Sequence logo for YOX1
Fisher’s P-value4.33e-13
Information content26.73
Max PWM score22.55
Recommended cutoff18.08
Position frequency matrix (PFM)
A | 0.570 0.950 0.001 0.001 0.950 0.001 0.190 0.048 0.001 0.048 0.048 0.001 0.001 0.713 0.950 0.618 0.523 0.286 0.001 0.001 
C | 0.381 0.048 0.001 0.143 0.001 0.808 0.048 0.001 0.001 0.001 0.950 0.997 0.238 0.001 0.048 0.001 0.238 0.001 0.001 0.048 
G | 0.001 0.001 0.001 0.001 0.001 0.190 0.524 0.001 0.001 0.001 0.001 0.001 0.001 0.285 0.001 0.048 0.001 0.476 0.997 0.950 
T | 0.048 0.001 0.997 0.855 0.048 0.001 0.238 0.950 0.997 0.950 0.001 0.001 0.760 0.001 0.001 0.333 0.238 0.238 0.001 0.001 
Position count matrix (PCM)
A |  56  95   0   0  95   0  19   4   0   4   4   0   0  71  95  61  52  28   0   0 
C |  38   4   0  14   0  80   4   0   0   0  95  99  23   0   4   0  23   0   0   4 
G |   0   0   0   0   0  19  52   0   0   0   0   0   0  28   0   4   0  47  99  95 
T |   4   0  99  85   4   0  23  95  99  95   0   0  76   0   0  33  23  23   0   0 
Position weight matrix (PWM)
A |  0.58  1.09 -5.77 -5.77  1.09 -5.77 -0.52 -1.90 -5.77 -1.90 -1.90 -5.77 -5.77  0.80  1.09  0.66  0.49 -0.11 -5.77 -5.77 
C |  0.75 -1.32 -5.19 -0.23 -5.19  1.50 -1.32 -5.19 -5.19 -5.19  1.66  1.71  0.28 -5.19 -1.32 -5.19  0.28 -5.19 -5.19 -1.32 
G | -5.19 -5.19 -5.19 -5.19 -5.19  0.05  1.07 -5.19 -5.19 -5.19 -5.19 -5.19 -5.19  0.46 -5.19 -1.32 -5.19  0.97  1.71  1.66 
T | -1.90 -5.77  1.14  0.98 -1.90 -5.77 -0.30  1.09  1.14  1.09 -5.77 -5.77  0.86 -5.77 -5.77  0.04 -0.30 -0.30 -5.77 -5.77 
YOX1Morozov et. al.P = 1View matrix ↘
Sequence logo for YOX1
Fisher’s P-value1
Information content8.912
Max PWM score15.44
Recommended cutoff10.93
Position frequency matrix (PFM)
A | 0.055 0.158 0.274 0.115 0.105 0.173 0.352 0.381 0.162 0.242 0.222 0.218 0.126 0.559 0.632 0.719 0.134 0.202 0.014 0.748 0.197 0.635 
C | 0.094 0.093 0.195 0.645 0.812 0.182 0.158 0.106 0.180 0.218 0.179 0.099 0.180 0.049 0.063 0.084 0.155 0.076 0.082 0.057 0.551 0.095 
G | 0.021 0.115 0.133 0.060 0.011 0.112 0.096 0.146 0.072 0.111 0.285 0.463 0.353 0.241 0.074 0.067 0.050 0.214 0.002 0.124 0.004 0.145 
T | 0.830 0.635 0.398 0.180 0.072 0.533 0.395 0.367 0.586 0.429 0.314 0.220 0.341 0.150 0.230 0.131 0.661 0.508 0.902 0.071 0.248 0.125 
Position count matrix (PCM)
A |   5  15  27  11  10  17  35  38  16  24  22  21  12  55  63  71  13  20   1  74  19  63 
C |   9   9  19  64  81  18  15  10  18  21  17   9  18   4   6   8  15   7   8   5  55   9 
G |   2  11  13   6   1  11   9  14   7  11  28  46  35  24   7   6   5  21   0  12   0  14 
T |  83  63  39  18   7  53  39  36  58  42  31  22  34  15  23  13  66  50  90   7  24  12 
Position weight matrix (PWM)
A | -1.76 -0.71 -0.16 -1.02 -1.11 -0.62  0.10  0.17 -0.68 -0.28 -0.37 -0.38 -0.93  0.56  0.68  0.81 -0.87 -0.46 -3.13  0.85 -0.49  0.69 
C | -0.65 -0.66  0.08  1.28  1.51  0.01 -0.13 -0.53  0.00  0.19 -0.01 -0.60  0.00 -1.30 -1.05 -0.76 -0.15 -0.86 -0.79 -1.15  1.12 -0.64 
G | -2.15 -0.45 -0.30 -1.10 -2.80 -0.47 -0.63 -0.21 -0.92 -0.48  0.46  0.94  0.67  0.29 -0.89 -0.99 -1.28  0.17 -4.50 -0.37 -3.81 -0.22 
T |  0.95  0.69  0.22 -0.58 -1.49  0.51  0.21  0.14  0.60  0.29 -0.02 -0.37  0.06 -0.76 -0.33 -0.89  0.73  0.46  1.04 -1.51 -0.25 -0.94 
YOX1Pachkov et alP = 5.73e-07View matrix ↘
Sequence logo for YOX1
Fisher’s P-value5.73e-07
Information content12.51
Max PWM score13.54
Recommended cutoff11.34
Position frequency matrix (PFM)
A | 0.868 0.010 0.090 0.695 0.125 0.431 0.004 0.015 0.148 0.001 0.051 0.087 0.354 0.684 0.482 
C | 0.119 0.001 0.239 0.003 0.597 0.100 0.026 0.032 0.181 0.919 0.717 0.377 0.137 0.080 0.101 
G | 0.005 0.010 0.015 0.298 0.167 0.111 0.001 0.010 0.001 0.003 0.063 0.058 0.319 0.023 0.001 
T | 0.008 0.979 0.656 0.004 0.111 0.358 0.971 0.942 0.672 0.078 0.169 0.479 0.191 0.212 0.417 
Position count matrix (PCM)
A |  86   1   9  69  12  43   0   1  14   0   5   8  35  68  48 
C |  11   0  23   0  59  10   2   3  18  91  71  37  13   8  10 
G |   0   1   1  29  16  11   0   1   0   0   6   5  31   2   0 
T |   0  97  65   0  11  35  97  94  67   7  16  47  19  21  41 
Position weight matrix (PWM)
A |  1.00 -3.47 -1.27  0.78 -0.94  0.30 -4.38 -3.06 -0.77 -5.77 -1.84 -1.30  0.10  0.76  0.41 
C | -0.41 -5.19  0.28 -4.09  1.20 -0.59 -1.93 -1.73  0.01  1.63  1.38  0.74 -0.27 -0.81 -0.58 
G | -3.58 -2.89 -2.48  0.50 -0.07 -0.48 -5.19 -2.89 -5.19 -4.09 -1.05 -1.13  0.57 -2.06 -5.19 
T | -3.69  1.12  0.72 -4.38 -1.06  0.11  1.11  1.08  0.74 -1.41 -0.64  0.40 -0.52 -0.41  0.26 
YOX1Zhu et. al.P = 0.01222View matrix ↘
Sequence logo for YOX1
Fisher’s P-value0.01222
Information content8.94
Max PWM score8.79
Recommended cutoff4.48
Position frequency matrix (PFM)
A | 0.64 0.01 0.11 0.97 0.96 0.03 0.01 0.78 0.69 0.35 
C | 0.09 0.27 0.10 0.01 0.01 0.01 0.01 0.01 0.03 0.09 
G | 0.11 0.03 0.01 0.01 0.01 0.01 0.01 0.10 0.27 0.10 
T | 0.17 0.69 0.78 0.01 0.03 0.96 0.97 0.11 0.01 0.46 
Position count matrix (PCM)
A |  64   1  11  97  96   3   1  78  69  35 
C |   9  27  10   1   1   1   1   1   3   9 
G |  11   3   1   1   1   1   1  10  27  10 
T |  17  69  78   1   3  96  97  11   1  46 
Position weight matrix (PWM)
A |  0.69 -3.47 -1.07  1.11  1.10 -2.37 -3.47  0.89  0.77  0.09 
C | -0.69  0.41 -0.59 -2.89 -2.89 -2.89 -2.89 -2.89 -1.79 -0.69 
G | -0.49 -1.79 -2.89 -2.89 -2.89 -2.89 -2.89 -0.59  0.41 -0.59 
T | -0.63  0.77  0.89 -3.47 -2.37  1.10  1.11 -1.07 -3.47  0.36 
YOX1Zhao and StormoP = 1View matrix ↘
Sequence logo for YOX1
Fisher’s P-value1
Information content2.895
Max PWM score3.98
Recommended cutoff3.98
Position frequency matrix (PFM)
A | 0.434 0.536 0.965 0.058 0.163 0.436 
C | 0.074 0.068 0.001 0.082 0.083 0.078 
G | 0.062 0.113 0.033 0.181 0.212 0.394 
T | 0.430 0.283 0.001 0.679 0.542 0.092 
Position count matrix (PCM)
A |  43  53  96   5  16  43 
C |   7   6   0   8   8   7 
G |   6  11   3  18  21  39 
T |  43  28   0  67  54   9 
Position weight matrix (PWM)
A |  0.30  0.52  1.10 -1.71 -0.67  0.31 
C | -0.89 -0.97 -5.19 -0.79 -0.77 -0.84 
G | -1.07 -0.47 -1.70  0.01  0.16  0.78 
T |  0.30 -0.12 -5.77  0.75  0.53 -1.25 
03 / EXPERIMENTAL CONTEXT

Gene-level annotations and interactions.

Genes bound in ChIP-chip experiments 111 genes

YAR018C, YBR089W, YBR099C, YBR202W, YCL054W, YCR018C-A, YCR019W, YCR024C-A, YCR096C, YDL068W, YDL071C, YDR003W, YDR034C-A, YDR040C, YDR041W, YDR042C, YDR077W, YDR084C, YDR098C-A, YDR098C-B, YDR144C, YDR145W, YDR190C, YDR191W, YDR210W-D, YDR278C, YDR434W, YDR495C, YDR496C, YEL032W, YER002W, YER013W, YER033C, YER034W, YER044C-A, YER071C, YER072W, YER135C, YFR002W, YGL001C, YGL004C, YGR071C, YGR072W, YGR092W, YGR218W, YGR273C, YHR011W, YHR043C, YHR085W, YHR098C, YHR099W, YHR151C, YHR152W, YHR182W, YIL014W, YIL119C, YIR005W, YJL030W, YJL031C, YJL139C, YJL175W, YJL191W, YJL192C, YJL194W, YJL196C, YJL203W, YJL204C, YJR011C, YJR051W, YJR094C, YKR004C, YKR040C, YKR042W, YKR056W, YLR011W, YLR023C, YLR047C, YLR048W, YLR254C, YLR261C, YLR262C, YLR273C, YLR274W, YLR428C, YLR430W, YMR019W, YMR098C, YMR193W, YMR194W, YMR258C, YNL001W, YNL002C, YNL038W, YNL050C, YNL070W, YNL145W, YNL146W, YNL258C, YOL003C, YOL115W, YOL159C, YOL160W, YOR058C, YOR066W, YOR148C, YPL051W, YPL106C, YPL188W, YPL216W, YPL217C, YPR104C

Genes affected by TF deletion 67 genes

YLR274W, YLR463C, YLR465C, YLR467W, YPL015C, YBR220C, YLR462W, YLR464W, YPL014W, YDL037C, YJR112W, YLL066C, YLR374C, YMR103C, YML027W, YNL303W, YMR104C, YPR019W, YBL026W, YBR250W, YLR121C, YCR021C, YKL051W, YOR043W, YHL049C, YLR281C, YMR017W, YMR023C, YNR066C, YOR228C, YOR384W, YKL022C, YHR215W, YIR035C, YLL067C, YAR071W, YJL188C, YDR026C, YKR061W, YKR093W, YML133C, YGR138C, YLR414C, YDR019C, YNL037C, YGR108W, YGR139W, YNL127W, YCL038C, YJL225C, YJL196C, YNR044W, YPL163C, YBR054W, YBL111C, YLR297W, YLR428C, YCR005C, YDR055W, YLR269C, YMR034C, YMR181C, YGR057C, YLR398C, YPR040W, YFL064C, YNR019W

Genes supported by both experiments 3 genes

YJL196C, YLR274W, YLR428C