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URC2

YDR520C, RRT4

View at SGD ↗

Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism

01 / RECOMMENDED MATRIX

Best-performing DNA-binding model.

RecommendedSource: Macisaac et. al
Fisher’s P-value7.89e-10
Information content17.29
Max PWM score15.15
Recommended cutoff13.7
View and copy the recommended matrices ↘
Position frequency matrix (PFM)
A | 0.162 0.036 0.072 0.001 0.001 0.001 0.107 0.001 0.001 0.162 0.662 
C | 0.088 0.924 0.036 0.959 0.997 0.001 0.072 0.997 0.001 0.088 0.088 
G | 0.123 0.001 0.107 0.004 0.001 0.997 0.820 0.001 0.994 0.588 0.088 
T | 0.627 0.039 0.785 0.036 0.001 0.001 0.001 0.001 0.004 0.162 0.162 
Position count matrix (PCM)
A |  16   3   7   0   0   0  10   0   0  16  66 
C |   8  92   3  95  99   0   7  99   0   8   8 
G |  12   0  10   0   0  99  82   0  99  58   8 
T |  62   3  78   3   0   0   0   0   0  16  16 
Position weight matrix (PWM)
A | -0.68 -2.18 -1.49 -5.77 -5.77 -5.77 -1.10 -5.77 -5.77 -0.68  0.73 
C | -0.72  1.64 -1.61  1.67  1.71 -5.19 -0.92  1.71 -5.19 -0.72 -0.72 
G | -0.38 -5.19 -0.52 -3.81 -5.19  1.71  1.52 -5.19  1.71  1.18 -0.72 
T |  0.67 -2.10  0.90 -2.18 -5.77 -5.77 -5.77 -5.77 -4.38 -0.68 -0.68 
02 / COMPARATIVE BENCHMARKS

Alternative candidate matrices 4

Historical matrix candidates from the original ScerTF database. Expand a source to inspect its original logo, scores, and matrix values.

URC2Badis et. al.P = 0.003356View matrix ↘
Sequence logo for URC2
Fisher’s P-value0.003356
Information content10.36
Max PWM score9.37
Recommended cutoff9.13
Position frequency matrix (PFM)
A | 0.01 0.01 0.01 0.73 0.23 0.55 0.14 0.92 
C | 0.97 0.01 0.01 0.09 0.17 0.01 0.01 0.06 
G | 0.01 0.97 0.97 0.17 0.46 0.01 0.01 0.01 
T | 0.01 0.01 0.01 0.01 0.14 0.43 0.84 0.01 
Position count matrix (PCM)
A |   1   1   1  73  23  55  14  92 
C |  97   1   1   9  17   1   1   6 
G |   1  97  97  17  46   1   1   1 
T |   1   1   1   1  14  43  84   1 
Position weight matrix (PWM)
A | -3.47 -3.47 -3.47  0.82 -0.33  0.54 -0.83  1.06 
C |  1.68 -2.89 -2.89 -0.69 -0.06 -2.89 -2.89 -1.10 
G | -2.89  1.68  1.68 -0.06  0.94 -2.89 -2.89 -2.89 
T | -3.47 -3.47 -3.47 -3.47 -0.83  0.30  0.97 -3.47 
URC2Foat et. al.P = 1View matrix ↘
Sequence logo for URC2
Fisher’s P-value1
Information content19.68
Max PWM score22.35
Recommended cutoff16.76
Position frequency matrix (PFM)
A | 0.01 0.18 0.13 0.01 0.91 0.01 0.08 0.46 0.02 0.44 0.41 0.46 0.05 0.12 0.11 0.29 0.01 0.01 0.01 0.11 0.29 0.28 
C | 0.27 0.06 0.36 0.01 0.01 0.01 0.55 0.06 0.48 0.54 0.05 0.39 0.07 0.21 0.11 0.20 0.08 0.01 0.01 0.42 0.29 0.01 
G | 0.18 0.01 0.47 0.97 0.06 0.01 0.20 0.34 0.02 0.02 0.47 0.08 0.39 0.67 0.44 0.01 0.04 0.97 0.97 0.07 0.37 0.65 
T | 0.54 0.75 0.04 0.01 0.02 0.97 0.17 0.14 0.49 0.01 0.08 0.07 0.48 0.01 0.34 0.49 0.87 0.01 0.01 0.39 0.05 0.06 
Position count matrix (PCM)
A |   1  18  13   1  91   1   8  46   2  44  41  46   5  12  11  28   1   1   1  11  28  28 
C |  27   6  36   1   1   1  55   6  48  54   5  39   7  21  11  20   8   1   1  42  28   1 
G |  18   1  47  97   6   1  20  34   2   2  47   8  39  67  44   1   4  97  97   7  37  65 
T |  54  75   4   1   2  97  17  14  49   1   8   7  48   1  34  49  87   1   1  39   5   6 
Position weight matrix (PWM)
A | -3.47 -0.58 -0.90 -3.47  1.05 -3.47 -1.39  0.36 -2.77  0.32  0.25  0.36 -1.86 -0.98 -1.07 -0.10 -3.47 -3.47 -3.47 -1.07 -0.10 -0.13 
C |  0.41 -1.10  0.69 -2.89 -2.89 -2.89  1.12 -1.10  0.98  1.10 -1.28  0.77 -0.94  0.15 -0.49  0.11 -0.81 -2.89 -2.89  0.85  0.48 -2.89 
G |  0.00 -2.89  0.96  1.68 -1.10 -2.89  0.11  0.64 -2.20 -2.20  0.96 -0.81  0.77  1.31  0.89 -2.89 -1.50  1.68  1.68 -0.94  0.72  1.28 
T |  0.52  0.85 -2.08 -3.47 -2.77  1.11 -0.63 -0.83  0.43 -3.47 -1.39 -1.52  0.41 -3.47  0.06  0.43  1.00 -3.47 -3.47  0.20 -1.86 -1.67 
URC2Zhu et. al.P = 0.00154View matrix ↘
Sequence logo for URC2
Fisher’s P-value0.00154
Information content13.75
Max PWM score11.3
Recommended cutoff9.23
Position frequency matrix (PFM)
A | 0.01 0.01 0.01 0.96 0.04 0.87 0.09 0.97 0.47 
C | 0.97 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.05 
G | 0.01 0.97 0.97 0.02 0.94 0.01 0.01 0.01 0.07 
T | 0.01 0.01 0.01 0.01 0.01 0.11 0.89 0.01 0.41 
Position count matrix (PCM)
A |   1   1   1  96   4  87   9  97  47 
C |  97   1   1   1   1   1   1   1   5 
G |   1  97  97   2  94   1   1   1   7 
T |   1   1   1   1   1  11  89   1  41 
Position weight matrix (PWM)
A | -3.47 -3.47 -3.47  1.10 -2.08  1.00 -1.27  1.11  0.38 
C |  1.68 -2.89 -2.89 -2.89 -2.89 -2.89 -2.89 -2.89 -1.28 
G | -2.89  1.68  1.68 -2.20  1.65 -2.89 -2.89 -2.89 -0.94 
T | -3.47 -3.47 -3.47 -3.47 -3.47 -1.07  1.02 -3.47  0.25 
URC2Zhao and StormoP = 1View matrix ↘
Sequence logo for URC2
Fisher’s P-value1
Information content1.491
Max PWM score4.44
Recommended cutoff3.96
Position frequency matrix (PFM)
A | 0.363 0.237 0.267 0.147 0.402 0.409 0.424 0.464 
C | 0.195 0.206 0.267 0.411 0.042 0.122 0.112 0.125 
G | 0.315 0.346 0.247 0.170 0.467 0.272 0.238 0.260 
T | 0.127 0.212 0.219 0.272 0.089 0.197 0.226 0.151 
Position count matrix (PCM)
A |  36  23  26  14  40  40  42  46 
C |  19  20  26  41   4  12  11  12 
G |  31  34  24  17  46  27  23  26 
T |  12  21  21  27   8  19  22  15 
Position weight matrix (PWM)
A |  0.13 -0.30 -0.18 -0.78  0.23  0.25  0.28  0.37 
C |  0.08  0.13  0.39  0.83 -1.46 -0.39 -0.47 -0.36 
G |  0.56  0.65  0.32 -0.06  0.95  0.41  0.28  0.37 
T | -0.92 -0.41 -0.38 -0.16 -1.28 -0.49 -0.35 -0.75 
03 / EXPERIMENTAL CONTEXT

Gene-level annotations and interactions.

Genes bound in ChIP-chip experiments 1 genes

No Data

Genes affected by TF deletion 1 genes

No Data

Genes supported by both experiments 1 genes

No Data