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THO2

YNL139C, RLR1, LDB5, ZRG13

View at SGD ↗

Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids

01 / RECOMMENDED MATRIX

Best-performing DNA-binding model.

RecommendedSource: Harbison et. al.
Fisher’s P-value2.03e-11
Information content12.41
Max PWM score11.75
Recommended cutoff7.64
View and copy the recommended matrices ↘
Position frequency matrix (PFM)
A | 0.875 0.001 0.083 0.167 0.208 0.001 0.208 0.208 0.042 0.333 0.001 0.292 
C | 0.083 0.001 0.001 0.001 0.001 0.958 0.125 0.083 0.875 0.001 0.001 0.167 
G | 0.001 0.001 0.001 0.001 0.001 0.001 0.083 0.083 0.001 0.125 0.001 0.001 
T | 0.042 1.000 0.916 0.833 0.792 0.042 0.583 0.625 0.083 0.541 1.000 0.541 
Position count matrix (PCM)
A |  87   0   8  16  20   0  20  20   4  33   0  29 
C |   8   0   0   0   0  95  12   8  87   0   0  16 
G |   0   0   0   0   0   0   8   8   0  12   0   0 
T |   4 100  91  83  79   4  58  62   8  54 100  54 
Position weight matrix (PWM)
A |  1.01 -5.77 -1.35 -0.65 -0.43 -5.77 -0.43 -0.43 -2.03  0.04 -5.77 -0.09 
C | -0.77 -5.19 -5.19 -5.19 -5.19  1.67 -0.36 -0.77  1.58 -5.19 -5.19 -0.07 
G | -5.19 -5.19 -5.19 -5.19 -5.19 -5.19 -0.77 -0.77 -5.19 -0.36 -5.19 -5.19 
T | -2.03  1.14  1.05  0.96  0.91 -2.03  0.60  0.67 -1.35  0.53  1.14  0.53 
02 / COMPARATIVE BENCHMARKS

Alternative candidate matrices 2

Historical matrix candidates from the original ScerTF database. Expand a source to inspect its original logo, scores, and matrix values.

THO2Foat et. al.P = 0.002183View matrix ↘
Sequence logo for THO2
Fisher’s P-value0.002183
Information content20
Max PWM score19.05
Recommended cutoff10.27
Position frequency matrix (PFM)
A | 0.01 0.41 0.06 0.95 0.01 0.01 0.07 0.62 0.01 0.07 0.01 0.06 0.97 0.16 0.59 0.01 
C | 0.09 0.22 0.47 0.03 0.96 0.97 0.01 0.37 0.59 0.05 0.97 0.64 0.01 0.60 0.35 0.50 
G | 0.49 0.33 0.35 0.01 0.02 0.01 0.92 0.01 0.06 0.86 0.01 0.30 0.01 0.20 0.01 0.02 
T | 0.41 0.04 0.11 0.01 0.01 0.01 0.01 0.01 0.35 0.02 0.01 0.01 0.01 0.04 0.05 0.48 
Position count matrix (PCM)
A |   1  41   6  95   1   1   7  62   1   7   1   6  97  16  59   1 
C |   9  22  47   3  96  97   1  37  59   5  97  64   1  60  35  50 
G |  49  33  35   1   2   1  92   1   6  86   1  30   1  20   1   2 
T |  41   4  11   1   1   1   1   1  35   2   1   1   1   4   5  48 
Position weight matrix (PWM)
A | -3.47  0.25 -1.67  1.09 -3.47 -3.47 -1.52  0.66 -3.47 -1.52 -3.47 -1.67  1.11 -0.69  0.61 -3.47 
C | -0.69  0.20  0.96 -1.79  1.67  1.68 -2.89  0.72  1.19 -1.28  1.68  1.27 -2.89  1.20  0.66  1.02 
G |  1.00  0.61  0.66 -2.89 -2.20 -2.89  1.63 -2.89 -1.10  1.56 -2.89  0.51 -2.89  0.11 -2.89 -2.20 
T |  0.25 -2.08 -1.07 -3.47 -3.47 -3.47 -3.47 -3.47  0.09 -2.77 -3.47 -3.47 -3.47 -2.08 -1.86  0.41 
THO2Macisaac et. alP = 7.23e-11View matrix ↘
Sequence logo for THO2
Fisher’s P-value7.23e-11
Information content18.98
Max PWM score15.42
Recommended cutoff11.27
Position frequency matrix (PFM)
A | 0.997 0.001 0.997 0.001 0.001 0.339 0.161 0.001 0.169 0.330 0.169 0.997 0.001 0.169 0.499 
C | 0.001 0.997 0.001 0.001 0.001 0.166 0.330 0.001 0.165 0.165 0.661 0.001 0.001 0.001 0.001 
G | 0.001 0.001 0.001 0.997 0.001 0.001 0.001 0.001 0.001 0.001 0.001 0.001 0.997 0.334 0.001 
T | 0.001 0.001 0.001 0.001 0.997 0.495 0.508 0.997 0.665 0.504 0.169 0.001 0.001 0.497 0.499 
Position count matrix (PCM)
A |  99   0  99   0   0  33  16   0  16  33  16  99   0  16  49 
C |   0  99   0   0   0  16  33   0  16  16  66   0   0   0   0 
G |   0   0   0  99   0   0   0   0   0   0   0   0  99  33   0 
T |   0   0   0   0  99  49  50  99  66  50  16   0   0  49  49 
Position weight matrix (PWM)
A |  1.14 -5.77  1.14 -5.77 -5.77  0.06 -0.69 -5.77 -0.64  0.03 -0.64  1.14 -5.77 -0.64  0.44 
C | -5.19  1.71 -5.19 -5.19 -5.19 -0.08  0.61 -5.19 -0.09 -0.09  1.30 -5.19 -5.19 -5.19 -5.19 
G | -5.19 -5.19 -5.19  1.71 -5.19 -5.19 -5.19 -5.19 -5.19 -5.19 -5.19 -5.19  1.71  0.62 -5.19 
T | -5.77 -5.77 -5.77 -5.77  1.14  0.44  0.46  1.14  0.73  0.45 -0.64 -5.77 -5.77  0.44  0.44 
03 / EXPERIMENTAL CONTEXT

Gene-level annotations and interactions.

Genes bound in ChIP-chip experiments 1 genes

No Data

Genes affected by TF deletion 1 genes

No Data

Genes supported by both experiments 1 genes

No Data