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SOK2

YMR016C

View at SGD ↗

Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factors

01 / RECOMMENDED MATRIX

Best-performing DNA-binding model.

RecommendedSource: Harbison et. al.
Fisher’s P-value1.66e-17
Information content7.493
Max PWM score8.21
Recommended cutoff6.27
View and copy the recommended matrices ↘
Position frequency matrix (PFM)
A | 0.083 0.035 0.040 0.853 0.037 0.153 0.407 0.558 
C | 0.190 0.005 0.947 0.005 0.080 0.233 0.213 0.122 
G | 0.108 0.946 0.005 0.134 0.744 0.504 0.198 0.157 
T | 0.619 0.014 0.008 0.008 0.140 0.111 0.182 0.163 
Position count matrix (PCM)
A |   8   3   4  85   3  15  40  55 
C |  19   0  94   0   8  23  21  12 
G |  10  94   0  13  74  50  19  15 
T |  61   1   0   0  14  11  18  16 
Position weight matrix (PWM)
A | -1.35 -2.21 -2.08  0.98 -2.16 -0.74  0.24  0.56 
C |  0.05 -3.58  1.66 -3.58 -0.81  0.26  0.17 -0.39 
G | -0.51  1.66 -3.58 -0.30  1.42  1.03  0.10 -0.14 
T |  0.66 -3.13 -3.69 -3.69 -0.83 -1.06 -0.56 -0.67 
02 / COMPARATIVE BENCHMARKS

Alternative candidate matrices 4

Historical matrix candidates from the original ScerTF database. Expand a source to inspect its original logo, scores, and matrix values.

SOK2Badis et. al.P = 6.25e-13View matrix ↘
Sequence logo for SOK2
Fisher’s P-value6.25e-13
Information content7.662
Max PWM score7.41
Recommended cutoff5.76
Position frequency matrix (PFM)
A | 0.41 0.04 0.04 0.04 0.97 0.05 
C | 0.47 0.01 0.01 0.91 0.01 0.05 
G | 0.09 0.04 0.94 0.01 0.01 0.50 
T | 0.03 0.91 0.01 0.04 0.01 0.40 
Position count matrix (PCM)
A |  41   4   4   4  97   5 
C |  47   1   1  91   1   5 
G |   9   4  94   1   1  50 
T |   3  91   1   4   1  40 
Position weight matrix (PWM)
A |  0.25 -2.08 -2.08 -2.08  1.11 -1.86 
C |  0.96 -2.89 -2.89  1.62 -2.89 -1.28 
G | -0.69 -1.50  1.65 -2.89 -2.89  1.02 
T | -2.37  1.05 -3.47 -2.08 -3.47  0.22 
SOK2_AFoat et. al.P = 2.10e-09View matrix ↘
Sequence logo for SOK2_A
Fisher’s P-value2.10e-09
Information content10.64
Max PWM score13.21
Recommended cutoff7.43
Position frequency matrix (PFM)
A | 0.17 0.46 0.29 0.25 0.92 0.74 0.36 0.30 0.07 0.82 0.84 0.93 0.73 0.42 0.07 
C | 0.60 0.12 0.03 0.04 0.06 0.01 0.10 0.43 0.31 0.01 0.15 0.01 0.15 0.01 0.48 
G | 0.22 0.32 0.60 0.23 0.01 0.25 0.47 0.27 0.50 0.01 0.01 0.05 0.01 0.24 0.31 
T | 0.01 0.11 0.07 0.48 0.01 0.01 0.07 0.01 0.12 0.16 0.01 0.01 0.11 0.34 0.14 
Position count matrix (PCM)
A |  17  46  28  25  92  74  36  30   7  82  84  93  73  42   7 
C |  60  12   3   4   6   1  10  43  31   1  15   1  15   1  48 
G |  22  32  60  23   1  25  47  27  50   1   1   5   1  24  31 
T |   1  11   7  48   1   1   7   1  12  16   1   1  11  34  14 
Position weight matrix (PWM)
A | -0.63  0.36 -0.10 -0.25  1.06  0.84  0.12 -0.06 -1.52  0.94  0.97  1.07  0.82  0.27 -1.52 
C |  1.20 -0.41 -1.79 -1.50 -1.10 -2.89 -0.59  0.87  0.54 -2.89 -0.18 -2.89 -0.18 -2.89  0.98 
G |  0.20  0.58  1.20  0.25 -2.89  0.33  0.96  0.41  1.02 -2.89 -2.89 -1.28 -2.89  0.29  0.54 
T | -3.47 -1.07 -1.52  0.41 -3.47 -3.47 -1.52 -3.47 -0.98 -0.69 -3.47 -3.47 -1.07  0.06 -0.83 
SOK2_BFoat et. al.P = 1.42e-11View matrix ↘
Sequence logo for SOK2_B
Fisher’s P-value1.42e-11
Information content13.94
Max PWM score12.57
Recommended cutoff6.9
Position frequency matrix (PFM)
A | 0.01 0.55 0.10 0.88 0.01 0.01 0.08 0.97 0.12 0.54 0.11 
C | 0.32 0.01 0.01 0.05 0.01 0.01 0.84 0.01 0.87 0.01 0.01 
G | 0.31 0.01 0.09 0.06 0.97 0.97 0.07 0.01 0.01 0.45 0.01 
T | 0.36 0.44 0.80 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.88 
Position count matrix (PCM)
A |   1  55  10  88   1   1   8  97  12  54  11 
C |  32   1   1   5   1   1  84   1  87   1   1 
G |  31   1   9   6  97  97   7   1   1  45   1 
T |  36  44  80   1   1   1   1   1   1   1  88 
Position weight matrix (PWM)
A | -3.47  0.54 -1.16  1.01 -3.47 -3.47 -1.39  1.11 -0.98  0.52 -1.07 
C |  0.58 -2.89 -2.89 -1.28 -2.89 -2.89  1.54 -2.89  1.58 -2.89 -2.89 
G |  0.54 -2.89 -0.69 -1.10  1.68  1.68 -0.94 -2.89 -2.89  0.92 -2.89 
T |  0.12  0.32  0.92 -3.47 -3.47 -3.47 -3.47 -3.47 -3.47 -3.47  1.01 
SOK2Macisaac et. alP = 6.86e-17View matrix ↘
Sequence logo for SOK2
Fisher’s P-value6.86e-17
Information content9.06
Max PWM score9.12
Recommended cutoff5.99
Position frequency matrix (PFM)
A | 0.336 0.115 0.845 0.009 0.003 0.339 0.946 0.655 
C | 0.076 0.599 0.001 0.158 0.001 0.528 0.021 0.321 
G | 0.421 0.001 0.153 0.814 0.995 0.048 0.032 0.023 
T | 0.168 0.285 0.001 0.019 0.001 0.085 0.001 0.001 
Position count matrix (PCM)
A |  33  11  84   0   0  33  94  65 
C |   7  59   0  15   0  52   2  32 
G |  42   0  15  81  99   4   3   2 
T |  16  28   0   1   0   8   0   0 
Position weight matrix (PWM)
A |  0.05 -1.02  0.97 -3.57 -4.67  0.06  1.08  0.72 
C | -0.86  1.20 -5.19 -0.13 -5.19  1.08 -2.15  0.58 
G |  0.85 -5.19 -0.16  1.51  1.71 -1.32 -1.73 -2.06 
T | -0.64 -0.12 -5.77 -2.82 -5.77 -1.33 -5.77 -5.77 
03 / EXPERIMENTAL CONTEXT

Gene-level annotations and interactions.

Genes bound in ChIP-chip experiments 52 genes

YAL064W, YBL029W, YBR280C, YCR098C, YDL245C, YDL246C, YDR077W, YDR098C, YDR259C, YDR441C, YDR442W, YEL040W, YEL069C, YEL070W, YER033C, YER034W, YER045C, YFL026W, YFL027C, YGL158W, YGR084C, YGR249W, YGR282C, YHR005C, YHR094C, YHR095W, YHR118C, YHR119W, YIL099W, YIL118W, YIL119C, YIL170W, YIL171W, YIL172C, YIR020C, YJL216C, YJL219W, YJL221C, YJR158W, YJR159W, YKL007W, YKL008C, YKL044W, YKL110C, YLR043C, YMR119W, YMR119W-A, YMR319C, YNL217W, YOL156W, YOL157C, YPR013C

Genes affected by TF deletion 93 genes

YKR012C, YMR016C, YHR146W, YKL043W, YOR071C, YPL047W, YGR279C, YKR013W, YOR192C, YHR179W, YKL044W, YPL016W, YDR342C, YGR033C, YHR053C, YLR342W, YMR105C, YOR317W, YGR250C, YMR314W, YFR016C, YBR093C, YBR067C, YBR129C, YFR006W, YOR086C, YER029C, YBR010W, YCR050C, YNL030W, YLR100W, YBR009C, YMR017W, YNR066C, YJR148W, YER001W, YLR101C, YOR074C, YDR343C, YOL150C, YJL217W, YFL014W, YLR313C, YLR377C, YOL149W, YPL137C, YBR264C, YBR296C, YKL062W, YNL255C, YER158C, YMR060C, YNL031C, YAR018C, YGR139W, YKL120W, YPL061W, YBR084C-A, YOR305W, YOR367W, YJL167W, YLR355C, YOL119C, YOL151W, YOL123W, YER094C, YER067W, YER044C, YER100W, YNR044W, YPL127C, YER091C, YMR002W, YGR176W, YGL255W, YLR237W, YLR300W, YMR034C, YMR038C, YKL009W, YAL061W, YGL032C, YGR147C, YHR135C, YHR139C, YLR079W, YNL264C, YDL027C, YHR049W, YLR398C, YIL011W, YOR374W, YPR176C

Genes supported by both experiments 1 genes

YKL044W

Predicted TF–TF partners 5 genes

AFT1, GIS1, RGM1, SKN7, USV1

Explore 5 original interaction plots →