S.ScerTFYeast transcription factor database Aaron Spivak
← All factors / TF RECORD

SKO1

YNL167C, ACR1

View at SGD ↗

Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, forms a complex with Tup1p and Ssn6p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses

01 / RECOMMENDED MATRIX

Best-performing DNA-binding model.

RecommendedSource: Macisaac et. al
Fisher’s P-value1.83e-12
Information content10.13
Max PWM score9.29
Recommended cutoff8.58
View and copy the recommended matrices ↘
Position frequency matrix (PFM)
A | 0.089 0.938 0.001 0.111 0.092 0.113 0.945 0.211 
C | 0.199 0.001 0.943 0.002 0.060 0.885 0.001 0.152 
G | 0.016 0.045 0.001 0.886 0.001 0.001 0.053 0.088 
T | 0.696 0.016 0.055 0.001 0.847 0.001 0.001 0.549
Position count matrix (PCM)
A |   8  93   0  11   9  11  94  21 
C |  19   0  94   0   6  88   0  15 
G |   1   4   0  88   0   0   5   8 
T |  69   1   5   0  84   0   0  54
Position weight matrix (PWM)
A | -1.28  1.08 -5.77 -1.06 -1.25 -1.04  1.08 -0.42 
C |  0.10 -5.19  1.66 -4.50 -1.10  1.59 -5.19 -0.17 
G | -2.42 -1.39 -5.19  1.59 -5.19 -5.19 -1.22 -0.72 
T |  0.78 -3.00 -1.76 -5.77  0.97 -5.77 -5.77  0.54
02 / COMPARATIVE BENCHMARKS

Alternative candidate matrices 7

Historical matrix candidates from the original ScerTF database. Expand a source to inspect its original logo, scores, and matrix values.

SKO1Foat et. al.P = 1.59e-07View matrix ↘
Sequence logo for SKO1
Fisher’s P-value1.59e-07
Information content16.22
Max PWM score14.24
Recommended cutoff8.94
Position frequency matrix (PFM)
A | 0.03 0.36 0.01 0.97 0.01 0.01 0.01 0.01 0.97 0.01 0.32 0.01 
C | 0.40 0.32 0.55 0.01 0.96 0.01 0.01 0.96 0.01 0.01 0.01 0.79 
G | 0.52 0.01 0.03 0.01 0.01 0.97 0.01 0.01 0.02 0.01 0.31 0.19 
T | 0.05 0.31 0.41 0.01 0.02 0.01 0.97 0.02 0.01 0.97 0.36 0.01
Position count matrix (PCM)
A |   3  36   1  97   1   1   1   1  97   1  32   1 
C |  40  32  55   1  96   1   1  96   1   1   1  79 
G |  52   1   3   1   1  97   1   1   2   1  31  19 
T |   5  31  41   1   2   1  97   2   1  97  36   1
Position weight matrix (PWM)
A | -2.37  0.12 -3.47  1.11 -3.47 -3.47 -3.47 -3.47  1.11 -3.47  0.00 -3.47 
C |  0.80  0.58  1.12 -2.89  1.67 -2.89 -2.89  1.67 -2.89 -2.89 -2.89  1.48 
G |  1.06 -2.89 -1.79 -2.89 -2.89  1.68 -2.89 -2.89 -2.20 -2.89  0.54  0.05 
T | -1.86 -0.03  0.25 -3.47 -2.77 -3.47  1.11 -2.77 -3.47  1.11  0.12 -3.47
Foat et. al.
SKO1_AFordyce et. al.P = 1.27e-12View matrix ↘
Fisher’s P-value1.27e-12
Information content7.151
Max PWM score8.13
Recommended cutoff7.34
Position frequency matrix (PFM)
A | 0.65 0.04 0.07 0.90 0.01 0.07 0.04 0.47 
C | 0.01 0.06 0.07 0.01 0.84 0.06 0.19 0.28 
G | 0.19 0.07 0.54 0.05 0.01 0.86 0.07 0.17 
T | 0.15 0.84 0.33 0.04 0.15 0.01 0.70 0.08
Position count matrix (PCM)
A |  65   4   7  90   1   7   4  47 
C |   1   6   7   1  84   6  19  28 
G |  19   7  54   5   1  86   7  17 
T |  15  84  33   4  15   1  70   8
Position weight matrix (PWM)
A |  0.71 -2.08 -1.52  1.03 -3.47 -1.52 -2.08  0.38 
C | -2.89 -1.10 -0.94 -2.89  1.54 -1.10  0.05  0.44 
G |  0.05 -0.94  1.10 -1.28 -2.89  1.56 -0.94 -0.06 
T | -0.76  0.97  0.03 -2.08 -0.76 -3.47  0.78 -1.39
Fordyce et. al.
SKO1_BFordyce et. al.P = 2.52e-09View matrix ↘
Fisher’s P-value2.52e-09
Information content7.398
Max PWM score8.41
Recommended cutoff6.66
Position frequency matrix (PFM)
A | 0.61 0.55 0.07 0.02 0.87 0.01 0.07 0.04 
C | 0.06 0.09 0.05 0.06 0.02 0.86 0.06 0.19 
G | 0.21 0.22 0.03 0.66 0.06 0.01 0.86 0.05 
T | 0.13 0.13 0.85 0.26 0.05 0.12 0.01 0.73
Position count matrix (PCM)
A |  61  55   7   2  87   1   7   4 
C |   6   9   5   6   2  86   6  19 
G |  21  22   3  66   6   1  86   5 
T |  13  13  85  26   5  12   1  73
Position weight matrix (PWM)
A |  0.65  0.54 -1.52 -2.77  1.00 -3.47 -1.52 -2.08 
C | -1.10 -0.69 -1.28 -1.10 -2.20  1.56 -1.10  0.05 
G |  0.15  0.20 -1.79  1.30 -1.10 -2.89  1.56 -1.28 
T | -0.90 -0.90  0.98 -0.21 -1.86 -0.98 -3.47  0.82
Fordyce et. al.
SKO1_CFordyce et. al.P = 2.01e-08View matrix ↘
Fisher’s P-value2.01e-08
Information content7.516
Max PWM score8.3
Recommended cutoff5.78
Position frequency matrix (PFM)
A | 0.01 0.01 0.94 0.01 0.10 0.04 0.45 0.66 
C | 0.05 0.11 0.01 0.85 0.04 0.24 0.29 0.01 
G | 0.11 0.63 0.01 0.01 0.84 0.07 0.13 0.16 
T | 0.84 0.25 0.04 0.14 0.02 0.65 0.13 0.18
Position count matrix (PCM)
A |   1   1  94   1  10   4  45  66 
C |   5  11   1  85   4  24  28   1 
G |  11  63   1   1  84   7  13  16 
T |  84  25   4  14   2  65  13  18
Position weight matrix (PWM)
A | -3.47 -3.47  1.08 -3.47 -1.16 -2.08  0.34  0.72 
C | -1.28 -0.49 -2.89  1.55 -1.50  0.29  0.48 -2.89 
G | -0.49  1.25 -2.89 -2.89  1.54 -0.94 -0.33 -0.12 
T |  0.97 -0.25 -2.08 -0.83 -2.77  0.71 -0.90 -0.58
Fordyce et. al.
SKO1Harbison et. al.P = 1.94e-09View matrix ↘
Sequence logo for SKO1
Fisher’s P-value1.94e-09
Information content10.69
Max PWM score8.34
Recommended cutoff8.34
Position frequency matrix (PFM)
A | 0.965 0.012 0.012 0.012 0.012 0.965 
C | 0.012 0.965 0.012 0.012 0.965 0.012 
G | 0.012 0.012 0.965 0.012 0.012 0.012 
T | 0.012 0.012 0.012 0.965 0.012 0.012
Position count matrix (PCM)
A |  96   1   1   1   1  96 
C |   1  96   1   1  96   1 
G |   1   1  96   1   1   1 
T |   1   1   1  96   1   1
Position weight matrix (PWM)
A |  1.10 -3.28 -3.28 -3.28 -3.28  1.10 
C | -2.71  1.68 -2.71 -2.71  1.68 -2.71 
G | -2.71 -2.71  1.68 -2.71 -2.71 -2.71 
T | -3.28 -3.28 -3.28  1.10 -3.28 -3.28
Harbison et. al.
SKO1Morozov et. al.P = 2.25e-09View matrix ↘
Sequence logo for SKO1
Fisher’s P-value2.25e-09
Information content7.414
Max PWM score8.88
Recommended cutoff7.25
Position frequency matrix (PFM)
A | 0.093 0.027 0.843 0.071 0.047 0.044 0.420 0.679 
C | 0.077 0.027 0.049 0.824 0.044 0.063 0.434 0.047 
G | 0.044 0.865 0.044 0.060 0.791 0.404 0.060 0.203 
T | 0.786 0.080 0.063 0.044 0.118 0.489 0.085 0.071
Position count matrix (PCM)
A |   9   2  84   7   4   4  42  67 
C |   7   2   4  82   4   6  43   4 
G |   4  86   4   6  79  40   6  20 
T |  78   8   6   4  11  48   8   7
Position weight matrix (PWM)
A | -1.24 -2.47  0.97 -1.51 -1.92 -1.98  0.27  0.75 
C | -0.85 -1.90 -1.30  1.52 -1.41 -1.05  0.88 -1.34 
G | -1.41  1.57 -1.41 -1.10  1.48  0.81 -1.10  0.12 
T |  0.90 -1.39 -1.63 -1.98 -1.00  0.42 -1.33 -1.51
Morozov et. al.
SKO1Pachkov et alP = 0.3698View matrix ↘
Sequence logo for SKO1
Fisher’s P-value0.3698
Information content13.96
Max PWM score10.25
Recommended cutoff9.76
Position frequency matrix (PFM)
A | 1.000 0.001 0.100 0.001 1.000 0.619 0.001 0.001 
C | 0.001 1.000 0.001 0.001 0.001 0.001 0.001 0.001 
G | 0.001 0.001 0.900 0.001 0.001 0.001 0.001 1.000 
T | 0.001 0.001 0.001 1.000 0.001 0.381 1.000 0.001
Position count matrix (PCM)
A | 100   0  10   0 100  61   0   0 
C |   0 100   0   0   0   0   0   0 
G |   0   0  90   0   0   0   0 100 
T |   0   0   0 100   0  38 100   0
Position weight matrix (PWM)
A |  1.14 -5.77 -1.16 -5.77  1.14  0.66 -5.77 -5.77 
C | -5.19  1.71 -5.19 -5.19 -5.19 -5.19 -5.19 -5.19 
G | -5.19 -5.19  1.61 -5.19 -5.19 -5.19 -5.19  1.71 
T | -5.77 -5.77 -5.77  1.14 -5.77  0.17  1.14 -5.77
Pachkov et al
03 / EXPERIMENTAL CONTEXT

Gene-level annotations and interactions.

Genes bound in ChIP-chip experiments 93 genes

YBL029W, YBL030C, YBL043W, YBR112C, YBR114W, YDR072C, YDR073W, YDR077W, YDR210W-D, YDR259C, YDR441C, YDR442W, YDR535C, YDR536W, YEL069C, YER017C, YER075C, YER076C, YER149C, YER150W, YFL014W, YFL015C, YFL016C, YGR050C, YGR140W, YGR150C, YGR241C, YGR243W, YGR249W, YHL041W, YHR033W, YHR049W, YHR096C, YIL119C, YIL122W, YIL170W, YIL171W, YIL172C, YJL106W, YJL107C, YJL108C, YJL219W, YJL221C, YJR145C, YJR146W, YJR147W, YKL060C, YKL096W, YKL110C, YKR040C, YKR042W, YLR108C, YLR109W, YLR286C, YLR300W, YMR017W, YMR037C, YMR070W, YMR135C, YMR136W, YMR151W, YMR172C-A, YMR173W, YMR173W-A, YMR239C, YMR303C, YMR304W, YNL178W, YNR034W, YOL156W, YOL157C, YOR028C, YOR029W, YOR246C, YOR247W, YOR248W, YOR317W, YOR318C, YOR319W, YOR348C, YOR349W, YOR374W, YPL024W, YPL025C, YPL061W, YPL062W, YPL081W, YPL082C, YPR005C, YPR013C, YPR063C, YPR064W, YPR065W

Genes affected by TF deletion 138 genes

YDR368W, YML112W, YNR061C, YHR146W, YPL053C, YCL047C, YNR060W, YPL177C, YAL053W, YBR157C, YBR161W, YOR038C, YPL016W, YOL136C, YPL135W, YML027W, YNR026C, YNR028W, YBR067C, YBR129C, YFR006W, YJR144W, YMR104C, YNL116W, YBL058W, YBR288C, YDR309C, YDR279W, YER029C, YGR243W, YIL015W, YKL206C, YLR183C, YIL118W, YOR229W, YPL215W, YAR015W, YOR043W, YDR077W, YNR066C, YJR148W, YLR099C, YMR199W, YOR074C, YHR033W, YOL150C, YBR265W, YDR347W, YGR220C, YNR035C, YPL118W, YPL122C, YPL092W, YPL156C, YBR135W, YFL048C, YGR012W, YHR094C, YLR343W, YOR324C, YOR354C, YPR057W, YOR341W, YCL027W, YBR264C, YDL201W, YER064C, YGL112C, YGR219W, YGR253C, YHR214W-A, YKL144C, YKL212W, YKL150W, YKL214C, YLR191W, YLR163C, YLR195C, YMR321C, YMR295C, YNR003C, YNR034W, YMR055C, YML131W, YNL065W, YKL096W, YNL289W, YDR019C, YLR260W, YMR060C, YNL098C, YNL100W, YAR018C, YGR108W, YGR139W, YOL156W, YOR367W, YJL167W, YHR096C, YLR353W, YOL151W, YOL155C, YBL071C, YNR044W, YPL163C, YBR054W, YHR018C, YIL170W, YLR297W, YGR144W, YHR200W, YMR247C, YIL169C, YLR300W, YMR034C, YNL076W, YBR244W, YEL037C, YGL032C, YJL108C, YLR049C, YLR081W, YLR452C, YDL023C, YDR122W, YHR049W, YNL167C, YNR018W, YBR089W, YDL022W, YFR025C, YGR052W, YJL044C, YIL010W, YIL041W, YNR052C, YNL330C, YOR184W

Genes supported by both experiments 11 genes

YDR077W, YGR243W, YHR033W, YHR049W, YHR096C, YIL170W, YJL108C, YKL096W, YLR300W, YNR034W, YOL156W

Predicted TF–TF partners 1 genes

SUM1

Explore 1 original interaction plots →