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SFL1

YOR140W

View at SGD ↗

Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p

01 / RECOMMENDED MATRIX

Best-performing DNA-binding model.

RecommendedSource: Zhu et. al.
Fisher’s P-value0.01765
Information content8.962
Max PWM score10.47
Recommended cutoff7.73
View and copy the recommended matrices ↘
Position frequency matrix (PFM)
A | 0.73 0.13 0.50 0.02 0.95 0.96 0.02 0.62 0.60 0.54 0.26 0.49 0.43 0.37 0.41 
C | 0.03 0.18 0.26 0.01 0.02 0.01 0.05 0.13 0.13 0.22 0.16 0.10 0.07 0.12 0.12 
G | 0.12 0.11 0.23 0.96 0.01 0.02 0.81 0.22 0.04 0.05 0.15 0.22 0.10 0.15 0.07 
T | 0.12 0.59 0.01 0.01 0.02 0.01 0.12 0.04 0.23 0.19 0.44 0.19 0.40 0.36 0.40 
Position count matrix (PCM)
A |  73  13  50   2  95  96   2  62  60  54  26  49  43  37  41 
C |   3  18  26   1   2   1   5  13  13  22  16  10   7  12  12 
G |  12  11  23  96   1   2  81  22   4   5  15  22  10  15   7 
T |  12  59   1   1   2   1  12   4  23  19  44  19  40  36  40 
Position weight matrix (PWM)
A |  0.82 -0.90  0.45 -2.77  1.09  1.10 -2.77  0.66  0.63  0.52 -0.21  0.43  0.30  0.15  0.25 
C | -1.79  0.00  0.37 -2.89 -2.20 -2.89 -1.28 -0.33 -0.33  0.20 -0.12 -0.59 -0.94 -0.41 -0.41 
G | -0.41 -0.49  0.25  1.67 -2.89 -2.20  1.50  0.20 -1.50 -1.28 -0.18  0.20 -0.59 -0.18 -0.94 
T | -0.98  0.61 -3.47 -3.47 -2.77 -3.47 -0.98 -2.08 -0.33 -0.52  0.32 -0.52  0.22  0.12  0.22 
02 / COMPARATIVE BENCHMARKS

Alternative candidate matrices 3

Historical matrix candidates from the original ScerTF database. Expand a source to inspect its original logo, scores, and matrix values.

SFL1Foat et. al.P = 1View matrix ↘
Sequence logo for SFL1
Fisher’s P-value1
Information content21.34
Max PWM score23.16
Recommended cutoff17.37
Position frequency matrix (PFM)
A | 0.15 0.12 0.04 0.97 0.89 0.01 0.33 0.22 0.04 0.01 0.41 0.01 0.62 0.01 0.23 0.10 0.16 0.01 0.01 0.01 0.01 0.30 0.17 0.69 
C | 0.21 0.01 0.23 0.01 0.10 0.97 0.04 0.29 0.50 0.10 0.05 0.49 0.01 0.01 0.33 0.15 0.11 0.59 0.07 0.01 0.97 0.01 0.32 0.02 
G | 0.59 0.85 0.07 0.01 0.01 0.01 0.03 0.37 0.33 0.21 0.13 0.44 0.04 0.51 0.28 0.47 0.16 0.36 0.01 0.96 0.01 0.07 0.05 0.03 
T | 0.06 0.02 0.67 0.01 0.01 0.01 0.60 0.12 0.12 0.69 0.41 0.06 0.34 0.48 0.16 0.28 0.57 0.04 0.92 0.02 0.01 0.63 0.47 0.27 
Position count matrix (PCM)
A |  15  12   4  97  89   1  33  22   4   1  41   1  62   1  23  10  16   1   1   1   1  30  17  69 
C |  21   1  23   1  10  97   4  28  50  10   5  49   1   1  33  15  11  59   7   1  97   1  32   2 
G |  59  85   7   1   1   1   3  37  33  21  13  44   4  51  28  47  16  36   1  96   1   7   5   3 
T |   6   2  67   1   1   1  60  12  12  69  41   6  34  48  16  28  56   4  92   2   1  63  47  27 
Position weight matrix (PWM)
A | -0.76 -0.98 -2.08  1.11  1.02 -3.47  0.03 -0.37 -2.08 -3.47  0.25 -3.47  0.66 -3.47 -0.33 -1.16 -0.69 -3.47 -3.47 -3.47 -3.47 -0.06 -0.63  0.77 
C |  0.15 -2.89  0.25 -2.89 -0.59  1.68 -1.50  0.48  1.02 -0.59 -1.28  1.00 -2.89 -2.89  0.61 -0.18 -0.49  1.19 -0.94 -2.89  1.68 -2.89  0.58 -2.20 
G |  1.19  1.55 -0.94 -2.89 -2.89 -2.89 -1.79  0.72  0.61  0.15 -0.33  0.89 -1.50  1.04  0.44  0.96 -0.12  0.69 -2.89  1.67 -2.89 -0.94 -1.28 -1.79 
T | -1.67 -2.77  0.74 -3.47 -3.47 -3.47  0.63 -0.98 -0.98  0.77  0.25 -1.67  0.06  0.41 -0.69 -0.13  0.58 -2.08  1.06 -2.77 -3.47  0.68  0.38 -0.17 
SFL1Macisaac et. alP = 0.2694View matrix ↘
Sequence logo for SFL1
Fisher’s P-value0.2694
Information content14.23
Max PWM score11.12
Recommended cutoff6.73
Position frequency matrix (PFM)
A | 0.012 0.964 0.964 0.012 0.012 0.012 0.012 0.012 
C | 0.012 0.012 0.012 0.012 0.964 0.012 0.012 0.964 
G | 0.964 0.012 0.012 0.964 0.012 0.012 0.012 0.012 
T | 0.012 0.012 0.012 0.012 0.012 0.964 0.964 0.012 
Position count matrix (PCM)
A |   1  96  96   1   1   1   1   1 
C |   1   1   1   1  96   1   1  96 
G |  96   1   1  96   1   1   1   1 
T |   1   1   1   1   1  96  96   1 
Position weight matrix (PWM)
A | -3.28  1.10  1.10 -3.28 -3.28 -3.28 -3.28 -3.28 
C | -2.71 -2.71 -2.71 -2.71  1.68 -2.71 -2.71  1.68 
G |  1.68 -2.71 -2.71  1.68 -2.71 -2.71 -2.71 -2.71 
T | -3.28 -3.28 -3.28 -3.28 -3.28  1.10  1.10 -3.28 
SFL1Zhao and StormoP = 1View matrix ↘
Sequence logo for SFL1
Fisher’s P-value1
Information content0.6595
Max PWM score3.47
Recommended cutoff2.87
Position frequency matrix (PFM)
A | 0.222 0.289 0.274 0.321 0.319 0.322 0.243 0.275 
C | 0.211 0.227 0.296 0.183 0.160 0.256 0.227 0.232 
G | 0.225 0.280 0.274 0.308 0.303 0.212 0.303 0.264 
T | 0.342 0.204 0.156 0.187 0.218 0.210 0.227 0.229 
Position count matrix (PCM)
A |  22  28  27  32  31  32  24  27 
C |  21  22  29  18  16  25  22  23 
G |  22  28  27  30  30  21  30  26 
T |  34  20  15  18  21  21  22  22 
Position weight matrix (PWM)
A | -0.37 -0.10 -0.16  0.00 -0.00  0.01 -0.28 -0.15 
C |  0.16  0.23  0.50  0.02 -0.12  0.35  0.23  0.25 
G |  0.22  0.44  0.42  0.54  0.52  0.16  0.52  0.38 
T |  0.07 -0.45 -0.72 -0.54 -0.38 -0.42 -0.34 -0.33 
03 / EXPERIMENTAL CONTEXT

Gene-level annotations and interactions.

Genes bound in ChIP-chip experiments 43 genes

YAR023C, YBL018C, YBR062C, YBR064W, YBR234C, YBR235W, YCL002C, YCL006C, YCL007C, YCL008C, YCL009C, YCL010C, YCR002C, YCR004C, YCR005C, YCR006C, YCR008W, YCR012W, YCR083W, YDL037C, YDL195W, YDR141C, YDR279W, YDR441C, YDR442W, YFR054C, YGL205W, YGL206C, YGR126W, YGR157W, YGR229C, YGR230W, YGR246C, YGR247W, YGR289C, YJR041C, YJR042W, YLR353W, YMR221C, YNR065C, YNR066C, YOR106W, YPR135W

Genes affected by TF deletion 38 genes

YDR068W, YKL043W, YOR381W, YPR082C, YNR060W, YLR087C, YOR382W, YAR064W, YAR068W, YBR129C, YFR006W, YKR102W, YDL155W, YBR042C, YHR003C, YMR173W, YOL052C, YHR214W, YOR341W, YBL061C, YBR260C, YHR214W-A, YOR168W, YKR093W, YPL062W, YCL075W, YMR173W-A, YBR144C, YDR144C, YOR383C, YGR044C, YCR036W, YFL003C, YGL258W, YHR018C, YML021C, YLR269C, YKL010C