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RDR1

YOR380W

View at SGD ↗

Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins

01 / RECOMMENDED MATRIX

Best-performing DNA-binding model.

RecommendedSource: Zhu et. al.
Fisher’s P-value0.02424
Information content10.32
Max PWM score9.05
Recommended cutoff9.05
View and copy the recommended matrices ↘
Position frequency matrix (PFM)
A | 0.02 0.01 0.01 0.01 0.81 0.34 0.79 
C | 0.10 0.97 0.01 0.01 0.02 0.01 0.07 
G | 0.81 0.01 0.97 0.97 0.16 0.02 0.11 
T | 0.07 0.01 0.01 0.01 0.01 0.63 0.03 
Position count matrix (PCM)
A |   2   1   1   1  81  34  79 
C |  10  97   1   1   2   1   7 
G |  81   1  97  97  16   2  11 
T |   7   1   1   1   1  63   3 
Position weight matrix (PWM)
A | -2.77 -3.47 -3.47 -3.47  0.93  0.06  0.90 
C | -0.59  1.68 -2.89 -2.89 -2.20 -2.89 -0.94 
G |  1.50 -2.89  1.68  1.68 -0.12 -2.20 -0.49 
T | -1.52 -3.47 -3.47 -3.47 -3.47  0.68 -2.37 
02 / COMPARATIVE BENCHMARKS

Alternative candidate matrices 3

Historical matrix candidates from the original ScerTF database. Expand a source to inspect its original logo, scores, and matrix values.

RDR1Badis et. al.P = 0.04357View matrix ↘
Sequence logo for RDR1
Fisher’s P-value0.04357
Information content11.34
Max PWM score9.3
Recommended cutoff9.3
Position frequency matrix (PFM)
A | 0.25 0.01 0.01 0.01 0.01 0.97 0.84 
C | 0.11 0.01 0.97 0.01 0.01 0.01 0.01 
G | 0.11 0.97 0.01 0.97 0.97 0.01 0.01 
T | 0.53 0.01 0.01 0.01 0.01 0.01 0.14 
Position count matrix (PCM)
A |  25   1   1   1   1  97  84 
C |  11   1  97   1   1   1   1 
G |  11  97   1  97  97   1   1 
T |  53   1   1   1   1   1  14 
Position weight matrix (PWM)
A | -0.25 -3.47 -3.47 -3.47 -3.47  1.11  0.97 
C | -0.49 -2.89  1.68 -2.89 -2.89 -2.89 -2.89 
G | -0.49  1.68 -2.89  1.68  1.68 -2.89 -2.89 
T |  0.50 -3.47 -3.47 -3.47 -3.47 -3.47 -0.83 
RDR1Foat et. al.P = 0.001636View matrix ↘
Sequence logo for RDR1
Fisher’s P-value0.001636
Information content17.8
Max PWM score17.98
Recommended cutoff11.39
Position frequency matrix (PFM)
A | 0.25 0.27 0.01 0.01 0.08 0.93 0.78 0.02 0.01 0.13 0.02 0.01 0.97 0.97 0.26 0.01 0.04 
C | 0.15 0.17 0.31 0.02 0.01 0.01 0.18 0.15 0.35 0.01 0.50 0.93 0.01 0.01 0.39 0.32 0.59 
G | 0.55 0.27 0.67 0.24 0.90 0.03 0.03 0.81 0.41 0.20 0.38 0.05 0.01 0.01 0.35 0.42 0.35 
T | 0.04 0.29 0.01 0.73 0.01 0.03 0.01 0.02 0.22 0.67 0.10 0.01 0.01 0.01 0.01 0.26 0.02 
Position count matrix (PCM)
A |  25  27   1   1   8  93  78   2   1  13   2   1  97  97  26   1   4 
C |  15  17  31   2   1   1  18  15  35   1  50  93   1   1  39  32  59 
G |  55  27  67  24  90   3   3  81  41  20  38   5   1   1  35  42  35 
T |   4  28   1  73   1   3   1   2  22  67  10   1   1   1   1  26   2 
Position weight matrix (PWM)
A | -0.25 -0.17 -3.47 -3.47 -1.39  1.07  0.89 -2.77 -3.47 -0.90 -2.77 -3.47  1.11  1.11 -0.21 -3.47 -2.08 
C | -0.18 -0.06  0.54 -2.20 -2.89 -2.89  0.00 -0.18  0.66 -2.89  1.02  1.64 -2.89 -2.89  0.77  0.58  1.19 
G |  1.12  0.41  1.31  0.29  1.61 -1.79 -1.79  1.50  0.82  0.11  0.75 -1.28 -2.89 -2.89  0.66  0.85  0.66 
T | -2.08 -0.10 -3.47  0.82 -3.47 -2.37 -3.47 -2.77 -0.37  0.74 -1.16 -3.47 -3.47 -3.47 -3.47 -0.21 -2.77 
RDR1Zhao and StormoP = 0.2651View matrix ↘
Sequence logo for RDR1
Fisher’s P-value0.2651
Information content6.794
Max PWM score6.39
Recommended cutoff6.39
Position frequency matrix (PFM)
A | 0.142 0.028 0.006 0.001 0.513 
C | 0.195 0.859 0.028 0.028 0.129 
G | 0.489 0.048 0.965 0.970 0.279 
T | 0.175 0.066 0.001 0.001 0.080 
Position count matrix (PCM)
A |  14   2   0   0  51 
C |  19  85   2   2  12 
G |  48   4  96  97  27 
T |  17   6   0   0   8 
Position weight matrix (PWM)
A | -0.81 -2.44 -3.98 -5.77  0.47 
C |  0.08  1.56 -1.86 -1.86 -0.33 
G |  1.00 -1.32  1.68  1.68  0.44 
T | -0.60 -1.58 -5.77 -5.77 -1.39 
03 / EXPERIMENTAL CONTEXT

Gene-level annotations and interactions.

Genes bound in ChIP-chip experiments 46 genes

YBL050W, YBL051C, YBR120C, YBR156C, YCR099C, YCR100C, YDR365C, YDR365W-A, YDR365W-B, YDR367W, YDR440W, YDR461W, YGR215W, YGR220C, YGR222W, YGR263C, YGR265W, YHR068W, YHR120W, YJL012C, YJL166W, YKL088W, YKL123W, YKL124W, YKL162C, YKL201C, YLR242C, YLR243W, YLR440C, YMR135W-A, YMR177W, YMR209C, YMR210W, YNL010W, YNL011C, YNL021W, YNL022C, YNL145W, YNL164C, YNL290W, YNL291C, YOR215C, YOR378W, YPL052W, YPL053C, YPL267W

Genes affected by TF deletion 65 genes

YML114C, YHR146W, YOR379C, YDR207C, YMR042W, YGR120C, YLR026C, YOR378W, YPL016W, YOR380W, YOL136C, YBR129C, YLL002W, YNL180C, YDR279W, YKL142W, YLR119W, YOR160W, YIL118W, YNL089C, YOR229W, YOR261C, YGR134W, YLR438C-A, YLR412W, YOR075W, YLR225C, YMR023C, YNL090W, YNR066C, YPL216W, YFR041C, YGR161C, YHR120W, YJL124C, YLR099C, YML007W, YMR145C, YNL155W, YOL149W, YNL065W, YLR416C, YNL289W, YOR051C, YPL066W, YLR292C, YNL100W, YDR209C, YDR177W, YKL001C, YOR367W, YNR045W, YOL155C, YJL196C, YER135C, YMR184W, YMR034C, YBR244W, YNL264C, YNL266W, YLR398C, YIL044C, YIL076W, YGR024C, YBR278W

Genes supported by both experiments 2 genes

YHR120W, YOR378W

Predicted TF–TF partners 3 genes

NRG1, RSC3, STB1

Explore 3 original interaction plots →