S.ScerTFYeast transcription factor database Aaron Spivak
← All factors / TF RECORD

PDR3

YBL005W, TPE2, AMY2

View at SGD ↗

Transcriptional activator of the pleiotropic drug resistance network, regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements)

01 / RECOMMENDED MATRIX

Best-performing DNA-binding model.

RecommendedSource: Morozov et. al.
Fisher’s P-value0.01537
Information content7.572
Max PWM score8.63
Recommended cutoff7.32
View and copy the recommended matrices ↘
Position frequency matrix (PFM)
A | 0.187 0.126 0.196 0.060 0.034 0.024 0.036 
C | 0.087 0.791 0.280 0.053 0.842 0.118 0.040 
G | 0.098 0.060 0.072 0.818 0.062 0.733 0.884 
T | 0.628 0.023 0.451 0.069 0.062 0.126 0.040
Position count matrix (PCM)
A |  18  12  19   6   3   2   3 
C |   8  79  28   5  84  11   4 
G |   9   6   7  81   6  73  88 
T |  62   2  45   6   6  12   4
Position weight matrix (PWM)
A | -0.54 -0.93 -0.49 -1.67 -2.24 -2.59 -2.18 
C | -0.73  1.48  0.44 -1.22  1.54 -0.42 -1.50 
G | -0.61 -1.10 -0.92  1.51 -1.07  1.40  1.59 
T |  0.67 -2.63  0.34 -1.53 -1.64 -0.93 -2.08
02 / COMPARATIVE BENCHMARKS

Alternative candidate matrices 8

Historical matrix candidates from the original ScerTF database. Expand a source to inspect its original logo, scores, and matrix values.

PDR3Foat et. al.P = 1View matrix ↘
Sequence logo for PDR3
Fisher’s P-value1
Information content16.2
Max PWM score15.9
Recommended cutoff11.93
Position frequency matrix (PFM)
A | 0.16 0.37 0.08 0.01 0.90 0.01 0.70 0.67 0.19 0.04 0.01 0.85 0.01 0.01 0.01 0.07 
C | 0.01 0.01 0.59 0.01 0.04 0.01 0.07 0.25 0.26 0.01 0.24 0.05 0.05 0.97 0.01 0.01 
G | 0.40 0.01 0.32 0.01 0.01 0.97 0.01 0.01 0.05 0.24 0.29 0.06 0.01 0.01 0.02 0.70 
T | 0.42 0.62 0.01 0.97 0.05 0.01 0.22 0.07 0.49 0.72 0.46 0.05 0.93 0.01 0.96 0.22
Position count matrix (PCM)
A |  16  37   8   1  90   1  70  67  19   4   1  85   1   1   1   7 
C |   1   1  59   1   4   1   7  25  26   1  24   5   5  97   1   1 
G |  40   1  32   1   1  97   1   1   5  24  28   6   1   1   2  70 
T |  42  62   1  97   5   1  22   7  49  72  46   5  93   1  96  22
Position weight matrix (PWM)
A | -0.69  0.15 -1.39 -3.47  1.03 -3.47  0.78  0.74 -0.52 -2.08 -3.47  0.98 -3.47 -3.47 -3.47 -1.52 
C | -2.89 -2.89  1.19 -2.89 -1.50 -2.89 -0.94  0.33  0.37 -2.89  0.29 -1.28 -1.28  1.68 -2.89 -2.89 
G |  0.80 -2.89  0.58 -2.89 -2.89  1.68 -2.89 -2.89 -1.28  0.29  0.48 -1.10 -2.89 -2.89 -2.20  1.36 
T |  0.27  0.66 -3.47  1.11 -1.86 -3.47 -0.37 -1.52  0.43  0.81  0.36 -1.86  1.07 -3.47  1.10 -0.37
Foat et. al.
PDR3_AFordyce et. al.P = 0.5735View matrix ↘
Fisher’s P-value0.5735
Information content7.162
Max PWM score8.1
Recommended cutoff4.89
Position frequency matrix (PFM)
A | 0.16 0.24 0.27 0.01 0.01 0.04 0.71 
C | 0.42 0.40 0.25 0.86 0.02 0.01 0.10 
G | 0.19 0.21 0.39 0.08 0.96 0.94 0.10 
T | 0.24 0.14 0.09 0.05 0.01 0.01 0.09
Position count matrix (PCM)
A |  16  24  27   1   1   4  71 
C |  42  40  25  86   2   1  10 
G |  19  21  39   8  96  94  10 
T |  24  14   9   5   1   1   9
Position weight matrix (PWM)
A | -0.69 -0.29 -0.17 -3.47 -3.47 -2.08  0.80 
C |  0.85  0.80  0.33  1.56 -2.20 -2.89 -0.59 
G |  0.05  0.15  0.77 -0.81  1.67  1.65 -0.59 
T | -0.29 -0.83 -1.27 -1.86 -3.47 -3.47 -1.27
Fordyce et. al.
PDR3_BFordyce et. al.P = 0.1947View matrix ↘
Fisher’s P-value0.1947
Information content6.972
Max PWM score7.34
Recommended cutoff7.34
Position frequency matrix (PFM)
A | 0.26 0.26 0.02 0.01 0.01 0.61 0.46 
C | 0.36 0.25 0.86 0.01 0.01 0.13 0.07 
G | 0.23 0.37 0.02 0.97 0.97 0.18 0.17 
T | 0.14 0.12 0.09 0.01 0.01 0.07 0.30
Position count matrix (PCM)
A |  26  26   2   1   1  61  46 
C |  36  25  86   1   1  13   7 
G |  23  37   2  97  97  18  17 
T |  14  12   9   1   1   7  30
Position weight matrix (PWM)
A | -0.21 -0.21 -2.77 -3.47 -3.47  0.65  0.36 
C |  0.69  0.33  1.56 -2.89 -2.89 -0.33 -0.94 
G |  0.25  0.72 -2.20  1.68  1.68  0.00 -0.06 
T | -0.83 -0.98 -1.27 -3.47 -3.47 -1.52 -0.06
Fordyce et. al.
PDR3_CFordyce et. al.P = 0.5358View matrix ↘
Fisher’s P-value0.5358
Information content6.665
Max PWM score7.04
Recommended cutoff3.98
Position frequency matrix (PFM)
A | 0.25 0.27 0.01 0.01 0.06 0.68 
C | 0.37 0.27 0.84 0.01 0.01 0.12 
G | 0.23 0.37 0.08 0.97 0.92 0.11 
T | 0.15 0.09 0.07 0.01 0.01 0.09
Position count matrix (PCM)
A |  25  27   1   1   6  68 
C |  37  27  84   1   1  12 
G |  23  37   8  97  92  11 
T |  15   9   7   1   1   9
Position weight matrix (PWM)
A | -0.25 -0.17 -3.47 -3.47 -1.67  0.75 
C |  0.72  0.41  1.54 -2.89 -2.89 -0.41 
G |  0.25  0.72 -0.81  1.68  1.63 -0.49 
T | -0.76 -1.27 -1.52 -3.47 -3.47 -1.27
Fordyce et. al.
PDR3Harbison et. al.P = 0.08976View matrix ↘
Sequence logo for PDR3
Fisher’s P-value0.08976
Information content15.81
Max PWM score12.28
Recommended cutoff12.28
Position frequency matrix (PFM)
A | 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.965 
C | 0.012 0.964 0.964 0.012 0.964 0.012 0.012 0.012 
G | 0.012 0.012 0.012 0.964 0.012 0.964 0.964 0.012 
T | 0.965 0.012 0.012 0.012 0.012 0.012 0.012 0.012
Position count matrix (PCM)
A |   1   1   1   1   1   1   1  96 
C |   1  96  96   1  96   1   1   1 
G |   1   1   1  96   1  96  96   1 
T |  96   1   1   1   1   1   1   1
Position weight matrix (PWM)
A | -3.28 -3.28 -3.28 -3.28 -3.28 -3.28 -3.28  1.10 
C | -2.71  1.68  1.68 -2.71  1.68 -2.71 -2.71 -2.71 
G | -2.71 -2.71 -2.71  1.68 -2.71  1.68  1.68 -2.71 
T |  1.10 -3.28 -3.28 -3.28 -3.28 -3.28 -3.28 -3.28
Harbison et. al.
PDR3Macisaac et. alP = 0.08976View matrix ↘
Sequence logo for PDR3
Fisher’s P-value0.08976
Information content15.81
Max PWM score12.28
Recommended cutoff12.28
Position frequency matrix (PFM)
A | 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.964 
C | 0.012 0.964 0.964 0.012 0.964 0.012 0.012 0.012 
G | 0.012 0.012 0.012 0.964 0.012 0.964 0.964 0.012 
T | 0.964 0.012 0.012 0.012 0.012 0.012 0.012 0.012
Position count matrix (PCM)
A |   1   1   1   1   1   1   1  96 
C |   1  96  96   1  96   1   1   1 
G |   1   1   1  96   1  96  96   1 
T |  96   1   1   1   1   1   1   1
Position weight matrix (PWM)
A | -3.28 -3.28 -3.28 -3.28 -3.28 -3.28 -3.28  1.10 
C | -2.71  1.68  1.68 -2.71  1.68 -2.71 -2.71 -2.71 
G | -2.71 -2.71 -2.71  1.68 -2.71  1.68  1.68 -2.71 
T |  1.10 -3.28 -3.28 -3.28 -3.28 -3.28 -3.28 -3.28
Macisaac et. al
PDR3Pachkov et alP = 0.03168View matrix ↘
Sequence logo for PDR3
Fisher’s P-value0.03168
Information content17.75
Max PWM score13.46
Recommended cutoff13.46
Position frequency matrix (PFM)
A | 0.001 0.001 0.001 0.001 0.001 0.400 0.001 0.001 0.001 0.933 
C | 0.133 0.333 0.001 1.000 1.000 0.001 1.000 0.001 0.067 0.001 
G | 0.133 0.001 0.001 0.001 0.001 0.600 0.001 1.000 0.933 0.067 
T | 0.733 0.667 1.000 0.001 0.001 0.001 0.001 0.001 0.001 0.001
Position count matrix (PCM)
A |   0   0   0   0   0  40   0   0   0  93 
C |  13  33   0 100 100   0 100   0   6   0 
G |  13   0   0   0   0  60   0 100  93   6 
T |  73  66 100   0   0   0   0   0   0   0
Position weight matrix (PWM)
A | -5.77 -5.77 -5.77 -5.77 -5.77  0.22 -5.77 -5.77 -5.77  1.07 
C | -0.30  0.62 -5.19  1.71  1.71 -5.19  1.71 -5.19 -0.99 -5.19 
G | -0.30 -5.19 -5.19 -5.19 -5.19  1.20 -5.19  1.71  1.65 -0.99 
T |  0.83  0.73  1.14 -5.77 -5.77 -5.77 -5.77 -5.77 -5.77 -5.77
Pachkov et al
PDR3Zhu J and MQ ZhangP = 0.08976View matrix ↘
Sequence logo for PDR3
Fisher’s P-value0.08976
Information content10.16
Max PWM score10.92
Recommended cutoff10.92
Position frequency matrix (PFM)
A | 0.05 0.05 0.05 0.09 0.05 0.05 0.05 0.82 
C | 0.05 0.86 0.86 0.05 0.64 0.05 0.09 0.05 
G | 0.05 0.05 0.05 0.82 0.05 0.86 0.82 0.09 
T | 0.86 0.05 0.05 0.05 0.27 0.05 0.05 0.05
Position count matrix (PCM)
A |   5   5   5   9   5   5   5  82 
C |   5  86  86   5  64   5   9   5 
G |   5   5   5  82   5  86  82   9 
T |  86   5   5   5  27   5   5   5
Position weight matrix (PWM)
A | -1.86 -1.86 -1.86 -1.27 -1.86 -1.86 -1.86  0.94 
C | -1.28  1.56  1.56 -1.28  1.27 -1.28 -0.69 -1.28 
G | -1.28 -1.28 -1.28  1.52 -1.28  1.56  1.52 -0.69 
T |  0.99 -1.86 -1.86 -1.86 -0.17 -1.86 -1.86 -1.86
Zhu J and MQ Zhang
03 / EXPERIMENTAL CONTEXT

Gene-level annotations and interactions.

Genes bound in ChIP-chip experiments 72 genes

YAR050W, YBL005W, YBL006C, YBL059W, YBR080C, YBR127C, YBR214W, YCR020C-A, YCR032W, YDL027C, YDL091C, YDR048C, YDR091C, YDR092W, YDR142C, YDR289C, YDR319C, YDR415C, YDR416W, YDR446W, YDR468C, YDR469W, YGL004C, YGL059W, YGL066W, YGL113W, YGR110W, YGR166W, YGR218W, YHR064C, YIL068C, YJL095W, YJR007W, YJR054W, YJR069C, YJR071W, YJR096W, YJR132W, YKL077W, YKL169C, YKR105C, YKR106W, YLR239C, YLR240W, YLR343W, YLR456W, YML093W, YML095C-A, YML096W, YML097C, YMR094W, YMR126C, YMR193W, YMR257C, YMR258C, YMR290W-A, YNL168C, YNL258C, YNR007C, YNR008W, YOL003C, YOL083W, YOR148C, YOR205C, YOR206W, YOR233W, YOR280C, YOR282W, YOR287C, YOR322C, YOR339C, YPR087W

Genes affected by TF deletion 79 genes

YJR054W, YML117W-A, YDL100C, YGL039W, YGL009C, YJL053W, YLR090W, YMR220W, YPL053C, YDR207C, YNL051W, YMR198W, YHR145C, YPL016W, YDR130C, YGL262W, YMR134W, YOL104C, YNR065C, YGL075C, YDR099W, YLR341W, YOR320C, YMR020W, YOR075W, YGL239C, YGL180W, YOR230W, YJR148W, YEL051W, YGL048C, YGR161C-D, YLR035C-A, YLR099C, YLR101C, YOR074C, YOR046C, YPL054W, YCR086W, YHR093W, YJR155W, YLL038C, YLR348C, YMR145C, YNR002C, YLR345W, YLR349W, YCL025C, YJL156C, YMR321C, YBR018C, YDR414C, YJR100C, YJR038C, YOL031C, YOR209C, YPL191C, YGL027C, YBR049C, YBR051W, YCL066W, YGL188C, YIL097W, YIL099W, YNL100W, YKL120W, YBR146W, YDR110W, YDR484W, YKL001C, YNL191W, YBL006C, YER100W, YJR006W, YJR107W, YHR135C, YEL010W, YLL025W, YCL006C

Genes supported by both experiments 2 genes

YBL006C, YJR054W

Predicted TF–TF partners 7 genes

CIN5, GSM1, MIG1, PDR8, RGT1, SUT1, YER184C

Explore 7 original interaction plots →