S.ScerTFYeast transcription factor database Aaron Spivak
← All factors / TF RECORD

PDR1

YGL013C, TPE3, TPE1, TIL1, SMR2, NRA2, CYH3, BOR2, ANT1, AMY1

View at SGD ↗

Zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes

01 / RECOMMENDED MATRIX

Best-performing DNA-binding model.

RecommendedSource: Macisaac et. al
Fisher’s P-value9.34e-15
Information content12.74
Max PWM score12.86
Recommended cutoff10.64
View and copy the recommended matrices ↘
Position frequency matrix (PFM)
A | 0.135 0.052 0.020 0.003 0.003 0.180 0.810 0.918 0.434 0.671 0.643 
C | 0.699 0.639 0.002 0.930 0.977 0.002 0.002 0.048 0.002 0.110 0.075 
G | 0.063 0.167 0.898 0.064 0.002 0.698 0.185 0.031 0.031 0.216 0.090 
T | 0.103 0.142 0.080 0.003 0.018 0.120 0.003 0.003 0.533 0.003 0.192
Position count matrix (PCM)
A |  13   5   2   0   0  18  81  91  43  67  64 
C |  69  63   0  93  97   0   0   4   0  11   7 
G |   6  16  89   6   0  69  18   3   3  21   9 
T |  10  14   8   0   1  12   0   0  53   0  19
Position weight matrix (PWM)
A | -0.86 -1.82 -2.77 -4.67 -4.67 -0.58  0.93  1.05  0.30  0.74  0.70 
C |  1.36  1.27 -4.50  1.64  1.69 -4.50 -4.50 -1.32 -4.50 -0.49 -0.88 
G | -1.05 -0.07  1.61 -1.03 -4.50  1.36  0.03 -1.76 -1.76  0.18 -0.69 
T | -1.13 -0.81 -1.39 -4.67 -2.88 -0.98 -4.67 -4.67  0.51 -4.67 -0.51
02 / COMPARATIVE BENCHMARKS

Alternative candidate matrices 9

Historical matrix candidates from the original ScerTF database. Expand a source to inspect its original logo, scores, and matrix values.

PDR1Badis et. al.P = 0.01202View matrix ↘
Sequence logo for PDR1
Fisher’s P-value0.01202
Information content11.47
Max PWM score10.29
Recommended cutoff5.79
Position frequency matrix (PFM)
A | 0.01 0.01 0.13 0.02 0.08 0.10 0.62 
C | 0.97 0.97 0.01 0.88 0.02 0.03 0.08 
G | 0.01 0.01 0.85 0.08 0.88 0.84 0.22 
T | 0.01 0.01 0.01 0.02 0.02 0.03 0.08
Position count matrix (PCM)
A |   1   1  13   2   8  10  62 
C |  97  97   1  88   2   3   8 
G |   1   1  85   8  88  84  22 
T |   1   1   1   2   2   3   8
Position weight matrix (PWM)
A | -3.47 -3.47 -0.90 -2.77 -1.39 -1.16  0.66 
C |  1.68  1.68 -2.89  1.59 -2.20 -1.79 -0.81 
G | -2.89 -2.89  1.55 -0.81  1.59  1.54  0.20 
T | -3.47 -3.47 -3.47 -2.77 -2.77 -2.37 -1.39
Badis et. al.
PDR1_AFoat et. al.P = 1View matrix ↘
Sequence logo for PDR1_A
Fisher’s P-value1
Information content19.55
Max PWM score19.51
Recommended cutoff14.63
Position frequency matrix (PFM)
A | 0.11 0.43 0.11 0.97 0.03 0.01 0.49 0.07 0.32 0.03 0.14 0.41 0.01 0.01 0.97 0.27 0.12 0.53 
C | 0.29 0.15 0.13 0.01 0.01 0.97 0.02 0.91 0.41 0.09 0.01 0.06 0.01 0.01 0.01 0.41 0.27 0.45 
G | 0.59 0.32 0.75 0.01 0.01 0.01 0.34 0.01 0.22 0.86 0.51 0.01 0.01 0.97 0.01 0.01 0.01 0.01 
T | 0.01 0.10 0.01 0.01 0.95 0.01 0.15 0.01 0.06 0.01 0.34 0.53 0.97 0.01 0.01 0.32 0.59 0.02
Position count matrix (PCM)
A |  11  43  11  97   3   1  49   7  32   3  14  41   1   1  97  27  12  53 
C |  28  15  13   1   1  97   2  91  41   9   1   6   1   1   1  41  27  45 
G |  59  32  75   1   1   1  34   1  22  86  51   1   1  97   1   1   1   1 
T |   1  10   1   1  95   1  15   1   6   1  34  53  97   1   1  32  59   2
Position weight matrix (PWM)
A | -1.07  0.30 -1.07  1.11 -2.37 -3.47  0.43 -1.52  0.00 -2.37 -0.83  0.25 -3.47 -3.47  1.11 -0.17 -0.98  0.50 
C |  0.48 -0.18 -0.33 -2.89 -2.89  1.68 -2.20  1.62  0.82 -0.69 -2.89 -1.10 -2.89 -2.89 -2.89  0.82  0.41  0.92 
G |  1.19  0.58  1.43 -2.89 -2.89 -2.89  0.64 -2.89  0.20  1.56  1.04 -2.89 -2.89  1.68 -2.89 -2.89 -2.89 -2.89 
T | -3.47 -1.16 -3.47 -3.47  1.09 -3.47 -0.76 -3.47 -1.67 -3.47  0.06  0.50  1.11 -3.47 -3.47  0.00  0.61 -2.77
Foat et. al.
PDR1_BFoat et. al.P = 1.12e-15View matrix ↘
Sequence logo for PDR1_B
Fisher’s P-value1.12e-15
Information content15.35
Max PWM score15.26
Recommended cutoff9.42
Position frequency matrix (PFM)
A | 0.75 0.04 0.69 0.02 0.97 0.01 0.06 0.05 0.83 0.01 0.39 0.20 0.26 
C | 0.10 0.29 0.01 0.88 0.01 0.97 0.60 0.80 0.01 0.97 0.04 0.04 0.59 
G | 0.14 0.01 0.15 0.09 0.01 0.01 0.01 0.14 0.15 0.01 0.57 0.01 0.01 
T | 0.01 0.67 0.15 0.01 0.01 0.01 0.33 0.01 0.01 0.01 0.01 0.76 0.14
Position count matrix (PCM)
A |  75   4  69   2  97   1   6   5  83   1  39  20  26 
C |  10  28   1  88   1  97  60  80   1  97   4   4  59 
G |  14   1  15   9   1   1   1  14  15   1  56   1   1 
T |   1  67  15   1   1   1  33   1   1   1   1  76  14
Position weight matrix (PWM)
A |  0.85 -2.08  0.77 -2.77  1.11 -3.47 -1.67 -1.86  0.95 -3.47  0.20 -0.47 -0.21 
C | -0.59  0.48 -2.89  1.59 -2.89  1.68  1.20  1.49 -2.89  1.68 -1.50 -1.50  1.19 
G | -0.25 -2.89 -0.18 -0.69 -2.89 -2.89 -2.89 -0.25 -0.18 -2.89  1.15 -2.89 -2.89 
T | -3.47  0.74 -0.76 -3.47 -3.47 -3.47  0.03 -3.47 -3.47 -3.47 -3.47  0.86 -0.83
Foat et. al.
PDR1Harbison et. al.P = 9.34e-15View matrix ↘
Sequence logo for PDR1
Fisher’s P-value9.34e-15
Information content12.74
Max PWM score12.86
Recommended cutoff10.64
Position frequency matrix (PFM)
A | 0.135 0.052 0.020 0.003 0.003 0.180 0.809 0.918 0.434 0.671 0.643 
C | 0.699 0.638 0.002 0.930 0.977 0.002 0.002 0.048 0.002 0.110 0.075 
G | 0.064 0.167 0.898 0.064 0.002 0.699 0.185 0.031 0.031 0.216 0.090 
T | 0.103 0.142 0.080 0.003 0.018 0.119 0.003 0.003 0.533 0.003 0.192
Position count matrix (PCM)
A |  13   5   2   0   0  18  80  91  43  67  64 
C |  69  63   0  93  97   0   0   4   0  11   7 
G |   6  16  89   6   0  69  18   3   3  21   9 
T |  10  14   8   0   1  11   0   0  53   0  19
Position weight matrix (PWM)
A | -0.86 -1.82 -2.77 -4.67 -4.67 -0.58  0.93  1.05  0.30  0.74  0.70 
C |  1.36  1.27 -4.50  1.64  1.69 -4.50 -4.50 -1.32 -4.50 -0.49 -0.88 
G | -1.03 -0.07  1.61 -1.03 -4.50  1.36  0.03 -1.76 -1.76  0.18 -0.69 
T | -1.13 -0.81 -1.39 -4.67 -2.88 -0.99 -4.67 -4.67  0.51 -4.67 -0.51
Harbison et. al.
PDR1Morozov et. al.P = 1.32e-08View matrix ↘
Sequence logo for PDR1
Fisher’s P-value1.32e-08
Information content9.094
Max PWM score9.42
Recommended cutoff5.62
Position frequency matrix (PFM)
A | 0.020 0.110 0.014 0.051 0.140 0.006 0.685 
C | 0.938 0.665 0.010 0.873 0.418 0.031 0.116 
G | 0.031 0.115 0.943 0.021 0.167 0.906 0.093 
T | 0.011 0.110 0.033 0.054 0.275 0.057 0.106
Position count matrix (PCM)
A |   2  11   1   5  14   0  68 
C |  93  66   1  87  41   3  11 
G |   3  11  94   2  16  90   9 
T |   1  11   3   5  27   5  10
Position weight matrix (PWM)
A | -2.77 -1.07 -3.13 -1.84 -0.83 -3.98  0.76 
C |  1.65  1.31 -2.89  1.58  0.84 -1.76 -0.44 
G | -1.76 -0.45  1.66 -2.15 -0.07  1.62 -0.66 
T | -3.37 -1.07 -2.27 -1.78 -0.15 -1.73 -1.10
Morozov et. al.
PDR1Pachkov et alP = 0.4615View matrix ↘
Sequence logo for PDR1
Fisher’s P-value0.4615
Information content17.75
Max PWM score13.46
Recommended cutoff9.58
Position frequency matrix (PFM)
A | 0.001 0.001 0.001 0.001 0.001 0.400 0.001 0.001 0.001 0.933 
C | 0.133 0.333 0.001 1.000 1.000 0.001 1.000 0.001 0.067 0.001 
G | 0.133 0.001 0.001 0.001 0.001 0.600 0.001 1.000 0.933 0.067 
T | 0.733 0.667 1.000 0.001 0.001 0.001 0.001 0.001 0.001 0.001
Position count matrix (PCM)
A |   0   0   0   0   0  40   0   0   0  93 
C |  13  33   0 100 100   0 100   0   6   0 
G |  13   0   0   0   0  60   0 100  93   6 
T |  73  66 100   0   0   0   0   0   0   0
Position weight matrix (PWM)
A | -5.77 -5.77 -5.77 -5.77 -5.77  0.22 -5.77 -5.77 -5.77  1.07 
C | -0.30  0.62 -5.19  1.71  1.71 -5.19  1.71 -5.19 -0.99 -5.19 
G | -0.30 -5.19 -5.19 -5.19 -5.19  1.20 -5.19  1.71  1.65 -0.99 
T |  0.83  0.73  1.14 -5.77 -5.77 -5.77 -5.77 -5.77 -5.77 -5.77
Pachkov et al
PDR1Zhu J and MQ ZhangP = 0.001875View matrix ↘
Sequence logo for PDR1
Fisher’s P-value0.001875
Information content10.16
Max PWM score10.92
Recommended cutoff5.86
Position frequency matrix (PFM)
A | 0.05 0.05 0.05 0.09 0.05 0.05 0.05 0.82 
C | 0.05 0.86 0.86 0.05 0.64 0.05 0.09 0.05 
G | 0.05 0.05 0.05 0.82 0.05 0.86 0.82 0.09 
T | 0.86 0.05 0.05 0.05 0.27 0.05 0.05 0.05
Position count matrix (PCM)
A |   5   5   5   9   5   5   5  82 
C |   5  86  86   5  64   5   9   5 
G |   5   5   5  82   5  86  82   9 
T |  86   5   5   5  27   5   5   5
Position weight matrix (PWM)
A | -1.86 -1.86 -1.86 -1.27 -1.86 -1.86 -1.86  0.94 
C | -1.28  1.56  1.56 -1.28  1.27 -1.28 -0.69 -1.28 
G | -1.28 -1.28 -1.28  1.52 -1.28  1.56  1.52 -0.69 
T |  0.99 -1.86 -1.86 -1.86 -0.17 -1.86 -1.86 -1.86
Zhu J and MQ Zhang
PDR1Zhu et. al.P = 0.6556View matrix ↘
Sequence logo for PDR1
Fisher’s P-value0.6556
Information content10.94
Max PWM score14.5
Recommended cutoff7.71
Position frequency matrix (PFM)
A | 0.49 0.21 0.21 0.13 0.07 0.04 0.01 0.02 0.16 0.82 0.72 0.16 0.39 0.24 0.32 0.37 0.53 
C | 0.05 0.42 0.24 0.13 0.05 0.77 0.93 0.04 0.03 0.06 0.02 0.31 0.08 0.37 0.13 0.16 0.07 
G | 0.23 0.28 0.24 0.02 0.06 0.03 0.04 0.93 0.77 0.05 0.13 0.21 0.33 0.14 0.19 0.31 0.37 
T | 0.23 0.09 0.31 0.72 0.82 0.16 0.02 0.01 0.04 0.07 0.13 0.32 0.21 0.25 0.36 0.16 0.03
Position count matrix (PCM)
A |  49  21  21  13   7   4   1   2  16  82  72  16  39  24  32  37  53 
C |   5  42  24  13   5  77  93   4   3   6   2  31   8  37  13  16   7 
G |  23  28  24   2   6   3   4  93  77   5  13  21  33  14  19  31  37 
T |  23   9  31  72  82  16   2   1   4   7  13  32  21  25  36  16   3
Position weight matrix (PWM)
A |  0.43 -0.42 -0.42 -0.90 -1.52 -2.08 -3.47 -2.77 -0.69  0.94  0.81 -0.69  0.20 -0.29  0.00  0.15  0.50 
C | -1.28  0.85  0.29 -0.33 -1.28  1.45  1.64 -1.50 -1.79 -1.10 -2.20  0.54 -0.81  0.72 -0.33 -0.12 -0.94 
G |  0.25  0.44  0.29 -2.20 -1.10 -1.79 -1.50  1.64  1.45 -1.28 -0.33  0.15  0.61 -0.25  0.05  0.54  0.72 
T | -0.33 -1.27 -0.03  0.81  0.94 -0.69 -2.77 -3.47 -2.08 -1.52 -0.90  0.00 -0.42 -0.25  0.12 -0.69 -2.37
Zhu et. al.
PDR1Zhao and StormoP = 1View matrix ↘
Sequence logo for PDR1
Fisher’s P-value1
Information content0.6421
Max PWM score3.43
Recommended cutoff2.85
Position frequency matrix (PFM)
A | 0.239 0.211 0.268 0.259 0.321 0.277 0.311 0.338 
C | 0.234 0.317 0.245 0.220 0.155 0.214 0.211 0.203 
G | 0.266 0.257 0.302 0.310 0.311 0.227 0.215 0.282 
T | 0.261 0.215 0.185 0.212 0.213 0.283 0.263 0.176
Position count matrix (PCM)
A |  23  21  26  25  32  27  31  33 
C |  23  31  24  22  15  21  21  20 
G |  26  25  30  31  31  22  21  28 
T |  26  21  18  21  21  28  26  17
Position weight matrix (PWM)
A | -0.29 -0.42 -0.18 -0.21  0.00 -0.14 -0.03  0.05 
C |  0.26  0.57  0.31  0.20 -0.15  0.17  0.16  0.12 
G |  0.39  0.36  0.52  0.54  0.55  0.23  0.18  0.45 
T | -0.20 -0.40 -0.55 -0.41 -0.41 -0.12 -0.20 -0.60
Zhao and Stormo
03 / EXPERIMENTAL CONTEXT

Gene-level annotations and interactions.

Genes bound in ChIP-chip experiments 163 genes

YAL022C, YAR002W, YBL001C, YBL087C, YBL109W, YBL111C, YBL112C, YBL113C, YBR040W, YBR057C, YBR159W, YBR190W, YBR191W, YCL065W, YCL066W, YCL067C, YCL068C, YCL074W, YCR105W, YDL075W, YDL076C, YDL082W, YDL083C, YDL099W, YDL100C, YDL114W, YDL115C, YDL130W, YDL147W, YDL148C, YDL223C, YDR042C, YDR064W, YDR235W, YDR282C, YDR342C, YDR366C, YDR368W, YDR418W, YDR470C, YDR471W, YDR543C, YDR544C, YDR545W, YEL054C, YER056C-A, YER074W, YER116C, YER117W, YFL034W, YFL063W, YFL064C, YFL065C, YFR017C, YFR031C-A, YFR039C, YFR040W, YGL006W, YGL103W, YGL104C, YGL115W, YGL135W, YGL136C, YGL189C, YGR085C, YGR117C, YGR118W, YGR296W, YHL049C, YHR021C, YHR021W-A, YHR087W, YHR091C, YHR138C, YHR141C, YHR142W, YHR193C, YHR194W, YHR197W, YIL018W, YIL128W, YIL129C, YIL133C, YIL148W, YIL149C, YIL152W, YIL174W, YIL175W, YIL177C, YJL042W, YJL134W, YJL135W, YJL136C, YJL188C, YJL189W, YJL190C, YJL191W, YJL192C, YJL225C, YJR044C, YLL065W, YLR047C, YLR048W, YLR057W, YLR207W, YLR354C, YLR406C, YLR407W, YLR462W, YLR463C, YLR464W, YLR465C, YLR466W, YLR467W, YML111W, YML132W, YML133C, YMR015C, YMR135W-A, YMR165C, YMR240C, YMR241W, YNL069C, YNL236W, YNL302C, YNL336W, YNL337W, YNL338W, YNL339C, YOL077W-A, YOL078W, YOL080C, YOL121C, YOR138C, YOR140W, YOR236W, YOR268C, YOR269W, YOR273C, YOR274W, YOR307C, YOR318C, YOR319W, YOR323C, YOR325W, YOR369C, YOR381W, YPL018W, YPL019C, YPL059W, YPL060C-A, YPL090C, YPL143W, YPL251W, YPL253C, YPL283C, YPR080W, YPR102C, YPR103W, YPR170C, YPR171W, YPR202W, YPR203W

Genes affected by TF deletion 120 genes

YJR052W, YLR214W, YBR223C, YDL094C, YGL013C, YOR377W, YKR072C, YNL051W, YBR157C, YLR399C, YPL016W, YGR035C, YBL053W, YBL057C, YDL190C, YDL224C, YER026C, YJL211C, YOR131C, YGR060W, YGR032W, YDL191W, YDL223C, YGL140C, YMR251W-A, YOR128C, YOR132W, YPR198W, YPR188C, YER149C, YER121W, YER151C, YER182W, YAL044C, YER007W, YBL104C, YKL219W, YDL101C, YDL132W, YDL133W, YDL137W, YDR259C, YEL023C, YER007C-A, YHR151C, YHR153C, YJL088W, YJL058C, YJL090C, YJL060W, YBL052C, YCL030C, YJL191W, YML091C, YPL154C, YDR133C, YIR037W, YNL231C, YMR319C, YPR199C, YPR171W, YDR448W, YCR022C, YGL247W, YGR108W, YKL120W, YOL158C, YLR136C, YML074C, YPR168W, YHR016C, YNL103W, YDL246C, YDL154W, YEL065W, YHR136C, YPR159W, YEL006W, YDR391C, YDR423C, YER134C, YJR043C, YKR068C, YMR034C, YDL119C, YGL068W, YKL071W, YLR081W, YPL075W, YPR103W, YPR162C, YER049W, YJR010W, YLR144C, YML081W, YOR155C, YCR100C, YFR031C, YLR016C, YLL025W, YNL134C, YNL198C, YOL097C, YOR370C, YCL010C, YDL181W, YGL130W, YJL200C, YJL202C, YJL204C, YJL174W, YKL193C, YMR277W, YMR309C, YNR052C, YOR120W, YOR156C, YOR188W, YPR190C, YPR173C

Genes supported by both experiments 4 genes

YDL223C, YJL191W, YPR103W, YPR171W

Predicted TF–TF partners 11 genes

ABF1, CAT8, DAL82, MIG1, MIG3, OAF1, RSC3, RSC30, RSF2, SUT1, YRM1

Explore 11 original interaction plots →