S.ScerTFYeast transcription factor database Aaron Spivak
← All factors / TF RECORD

NRG1

YDR043C

View at SGD ↗

Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response

01 / RECOMMENDED MATRIX

Best-performing DNA-binding model.

RecommendedSource: Aligned Matrix
Fisher’s P-value4.55e-47
Information content12.55
Max PWM score11.14
Recommended cutoff8.03
View and copy the recommended matrices ↘
Position frequency matrix (PFM)
A | 0.186 0.048 0.861 0.012 0.009 0.009 0.011 0.083 
C | 0.018 0.009 0.014 0.955 0.972 0.971 0.057 0.033 
G | 0.785 0.933 0.026 0.010 0.009 0.010 0.045 0.470 
T | 0.010 0.009 0.100 0.024 0.009 0.009 0.888 0.413
Position count matrix (PCM)
A |  18   4  86   1   0   0   1   8 
C |   1   0   1  95  97  97   5   3 
G |  78  93   2   1   0   1   4  47 
T |   1   0  10   2   0   0  88  41
Position weight matrix (PWM)
A | -0.54 -1.90  0.99 -3.28 -3.57 -3.57 -3.37 -1.35 
C | -2.30 -3.00 -2.55  1.67  1.69  1.69 -1.15 -1.70 
G |  1.47  1.65 -1.93 -2.89 -3.00 -2.89 -1.39  0.96 
T | -3.47 -3.57 -1.16 -2.59 -3.57 -3.57  1.02  0.26
02 / COMPARATIVE BENCHMARKS

Alternative candidate matrices 8

Historical matrix candidates from the original ScerTF database. Expand a source to inspect its original logo, scores, and matrix values.

NRG1_AFoat et. al.P = 2.49e-36View matrix ↘
Sequence logo for NRG1_A
Fisher’s P-value2.49e-36
Information content11.78
Max PWM score11.93
Recommended cutoff7.49
Position frequency matrix (PFM)
A | 0.12 0.34 0.29 0.01 0.65 0.03 0.01 0.01 0.01 0.05 
C | 0.10 0.41 0.06 0.01 0.03 0.88 0.97 0.97 0.19 0.03 
G | 0.23 0.13 0.64 0.97 0.10 0.01 0.01 0.01 0.19 0.67 
T | 0.55 0.12 0.01 0.01 0.22 0.08 0.01 0.01 0.61 0.25
Position count matrix (PCM)
A |  12  34  28   1  65   3   1   1   1   5 
C |  10  41   6   1   3  88  97  97  19   3 
G |  23  13  64  97  10   1   1   1  19  67 
T |  55  12   1   1  22   8   1   1  61  25
Position weight matrix (PWM)
A | -0.98  0.06 -0.10 -3.47  0.71 -2.37 -3.47 -3.47 -3.47 -1.86 
C | -0.59  0.82 -1.10 -2.89 -1.79  1.59  1.68  1.68  0.05 -1.79 
G |  0.25 -0.33  1.27  1.68 -0.59 -2.89 -2.89 -2.89  0.05  1.31 
T |  0.54 -0.98 -3.47 -3.47 -0.37 -1.39 -3.47 -3.47  0.65 -0.25
Foat et. al.
NRG1_BFoat et. al.P = 1.26e-06View matrix ↘
Sequence logo for NRG1_B
Fisher’s P-value1.26e-06
Information content16.98
Max PWM score14.97
Recommended cutoff8.29
Position frequency matrix (PFM)
A | 0.03 0.29 0.05 0.97 0.01 0.01 0.01 0.97 0.01 0.26 0.75 0.30 
C | 0.09 0.31 0.41 0.01 0.01 0.01 0.97 0.01 0.97 0.01 0.10 0.01 
G | 0.81 0.01 0.54 0.01 0.97 0.97 0.01 0.01 0.01 0.72 0.15 0.08 
T | 0.07 0.40 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.61
Position count matrix (PCM)
A |   3  28   5  97   1   1   1  97   1  26  75  30 
C |   9  31  41   1   1   1  97   1  97   1  10   1 
G |  81   1  54   1  97  97   1   1   1  72  15   8 
T |   7  40   1   1   1   1   1   1   1   1   1  61
Position weight matrix (PWM)
A | -2.37 -0.10 -1.86  1.11 -3.47 -3.47 -3.47  1.11 -3.47 -0.21  0.85 -0.06 
C | -0.69  0.54  0.82 -2.89 -2.89 -2.89  1.68 -2.89  1.68 -2.89 -0.59 -2.89 
G |  1.50 -2.89  1.10 -2.89  1.68  1.68 -2.89 -2.89 -2.89  1.39 -0.18 -0.81 
T | -1.52  0.22 -3.47 -3.47 -3.47 -3.47 -3.47 -3.47 -3.47 -3.47 -3.47  0.65
Foat et. al.
NRG1_CFoat et. al.P = 4.48e-08View matrix ↘
Sequence logo for NRG1_C
Fisher’s P-value4.48e-08
Information content16.56
Max PWM score14.76
Recommended cutoff11.29
Position frequency matrix (PFM)
A | 0.01 0.01 0.15 0.94 0.01 0.01 0.08 0.95 0.01 0.89 0.75 0.97 
C | 0.54 0.08 0.01 0.03 0.01 0.04 0.91 0.03 0.95 0.01 0.13 0.01 
G | 0.19 0.04 0.05 0.01 0.97 0.94 0.01 0.01 0.01 0.09 0.01 0.01 
T | 0.27 0.87 0.79 0.01 0.01 0.01 0.01 0.01 0.03 0.01 0.12 0.01
Position count matrix (PCM)
A |   1   1  15  94   1   1   8  95   1  89  75  97 
C |  54   8   1   3   1   4  91   3  95   1  13   1 
G |  19   4   5   1  97  94   1   1   1   9   1   1 
T |  27  87  79   1   1   1   1   1   3   1  12   1
Position weight matrix (PWM)
A | -3.47 -3.47 -0.76  1.08 -3.47 -3.47 -1.39  1.09 -3.47  1.02  0.85  1.11 
C |  1.10 -0.81 -2.89 -1.79 -2.89 -1.50  1.62 -1.79  1.66 -2.89 -0.33 -2.89 
G |  0.05 -1.50 -1.28 -2.89  1.68  1.65 -2.89 -2.89 -2.89 -0.69 -2.89 -2.89 
T | -0.17  1.00  0.90 -3.47 -3.47 -3.47 -3.47 -3.47 -2.37 -3.47 -0.98 -3.47
Foat et. al.
NRG1Harbison et. al.P = 9.87e-44View matrix ↘
Sequence logo for NRG1
Fisher’s P-value9.87e-44
Information content12.02
Max PWM score10.09
Recommended cutoff8.06
Position frequency matrix (PFM)
A | 0.182 0.016 0.777 0.005 0.004 0.004 0.013 
C | 0.024 0.006 0.016 0.943 0.987 0.983 0.028 
G | 0.780 0.974 0.050 0.005 0.003 0.009 0.106 
T | 0.014 0.005 0.156 0.048 0.006 0.004 0.853
Position count matrix (PCM)
A |  18   1  77   0   0   0   1 
C |   2   0   1  94  98  98   2 
G |  78  97   5   0   0   0  10 
T |   1   0  15   4   0   0  85
Position weight matrix (PWM)
A | -0.56 -3.00  0.89 -4.16 -4.38 -4.38 -3.20 
C | -2.01 -3.40 -2.42  1.66  1.70  1.70 -1.86 
G |  1.47  1.69 -1.28 -3.58 -4.09 -3.00 -0.53 
T | -3.13 -4.16 -0.72 -1.90 -3.98 -4.38  0.98
Harbison et. al.
NRG1Macisaac et. alP = 2.72e-44View matrix ↘
Sequence logo for NRG1
Fisher’s P-value2.72e-44
Information content10.42
Max PWM score9.68
Recommended cutoff7.58
Position frequency matrix (PFM)
A | 0.256 0.102 0.870 0.026 0.005 0.007 0.067 
C | 0.042 0.035 0.004 0.936 0.959 0.980 0.139 
G | 0.684 0.803 0.020 0.010 0.010 0.004 0.061 
T | 0.018 0.060 0.106 0.028 0.026 0.009 0.733
Position count matrix (PCM)
A |  25  10  87   2   0   0   6 
C |   4   3   0  93  95  98  13 
G |  68  80   2   1   1   0   6 
T |   1   6  10   2   2   0  73
Position weight matrix (PWM)
A | -0.22 -1.14  1.00 -2.51 -4.16 -3.82 -1.56 
C | -1.46 -1.64 -3.81  1.65  1.67  1.69 -0.26 
G |  1.34  1.50 -2.20 -2.89 -2.89 -3.81 -1.08 
T | -2.88 -1.67 -1.10 -2.44 -2.51 -3.57  0.83
Macisaac et. al
NRG1Pachkov et alP = 1.31e-35View matrix ↘
Sequence logo for NRG1
Fisher’s P-value1.31e-35
Information content10.62
Max PWM score9.04
Recommended cutoff7.45
Position frequency matrix (PFM)
A | 0.423 0.305 0.008 0.753 0.031 0.001 0.001 
C | 0.119 0.008 0.001 0.001 0.969 0.929 0.991 
G | 0.195 0.687 0.835 0.247 0.001 0.001 0.009 
T | 0.263 0.001 0.157 0.001 0.001 0.071 0.001
Position count matrix (PCM)
A |  42  30   0  75   3   0   0 
C |  11   0   0   0  96  92  99 
G |  19  68  83  24   0   0   0 
T |  26   0  15   0   0   7   0
Position weight matrix (PWM)
A |  0.28 -0.05 -3.69  0.86 -2.33 -5.77 -5.77 
C | -0.41 -3.11 -5.19 -5.19  1.68  1.64  1.71 
G |  0.08  1.34  1.53  0.32 -5.19 -5.19 -3.00 
T | -0.20 -5.77 -0.71 -5.77 -5.77 -1.51 -5.77
Pachkov et al
NRG1Zhu et. al.P = 4.71e-43View matrix ↘
Sequence logo for NRG1
Fisher’s P-value4.71e-43
Information content14.22
Max PWM score13.67
Recommended cutoff7.64
Position frequency matrix (PFM)
A | 0.46 0.94 0.01 0.01 0.01 0.07 0.01 0.01 0.50 0.25 0.12 0.22 
C | 0.49 0.01 0.01 0.01 0.01 0.01 0.92 0.81 0.09 0.20 0.30 0.07 
G | 0.01 0.04 0.97 0.97 0.97 0.01 0.01 0.01 0.04 0.24 0.27 0.55 
T | 0.05 0.01 0.01 0.01 0.01 0.91 0.06 0.17 0.37 0.31 0.30 0.16
Position count matrix (PCM)
A |  46  94   1   1   1   7   1   1  50  25  12  22 
C |  49   1   1   1   1   1  92  81   9  20  30   7 
G |   1   4  97  97  97   1   1   1   4  24  27  55 
T |   5   1   1   1   1  91   6  17  37  31  30  16
Position weight matrix (PWM)
A |  0.36  1.08 -3.47 -3.47 -3.47 -1.52 -3.47 -3.47  0.45 -0.25 -0.98 -0.37 
C |  1.00 -2.89 -2.89 -2.89 -2.89 -2.89  1.63  1.50 -0.69  0.11  0.51 -0.94 
G | -2.89 -1.50  1.68  1.68  1.68 -2.89 -2.89 -2.89 -1.50  0.29  0.41  1.12 
T | -1.86 -3.47 -3.47 -3.47 -3.47  1.05 -1.67 -0.63  0.15 -0.03 -0.06 -0.69
Zhu et. al.
NRG1Zhao and StormoP = 7.62e-36View matrix ↘
Sequence logo for NRG1
Fisher’s P-value7.62e-36
Information content7.877
Max PWM score7.97
Recommended cutoff6.63
Position frequency matrix (PFM)
A | 0.241 0.280 0.472 0.003 0.001 0.020 0.052 
C | 0.159 0.116 0.120 0.965 0.997 0.949 0.184 
G | 0.444 0.444 0.146 0.001 0.001 0.001 0.098 
T | 0.156 0.160 0.262 0.030 0.001 0.030 0.667
Position count matrix (PCM)
A |  24  28  47   0   0   2   5 
C |  15  11  12  96  99  94  18 
G |  44  44  14   0   0   0   9 
T |  15  16  26   3   0   3  66
Position weight matrix (PWM)
A | -0.28 -0.13  0.39 -4.67 -5.77 -2.77 -1.82 
C | -0.12 -0.44 -0.41  1.68  1.71  1.66  0.02 
G |  0.90  0.90 -0.21 -5.19 -5.19 -5.19 -0.61 
T | -0.72 -0.69 -0.20 -2.37 -5.77 -2.37  0.73
Zhao and Stormo
03 / EXPERIMENTAL CONTEXT

Gene-level annotations and interactions.

Genes bound in ChIP-chip experiments 136 genes

YAL017W, YAL018C, YAL022C, YAL064W, YBL029W, YBL043W, YBR040W, YBR099C, YBR157C, YDL037C, YDL122W, YDL245C, YDL246C, YDR040C, YDR041W, YDR042C, YDR043C, YDR052C, YDR077W, YDR133C, YDR134C, YDR259C, YDR343C, YDR434W, YDR441C, YDR442W, YDR535C, YDR536W, YEL007W, YEL040W, YEL069C, YEL070W, YER001W, YER011W, YER018C, YER019W, YER033C, YER034W, YER044C, YER045C, YFL059W, YFL060C, YFR017C, YGL158W, YGL227W, YGR050C, YGR218W, YGR249W, YGR277C, YGR278W, YHL041W, YHR012W, YHR033W, YHR049W, YHR138C, YHR156C, YHR157W, YHR193C, YHR194W, YHR195W, YIL019W, YIL020C, YIL040W, YIL097W, YIL098C, YIL099W, YIL118W, YIL119C, YIL122W, YIL170W, YIL171W, YIL172C, YIR013C, YIR014W, YIR020C, YJL105W, YJL216C, YJL219W, YJL221C, YJR094C, YJR102C, YJR103W, YJR158W, YJR159W, YKL044W, YKL177W, YKL179C, YKR102W, YLR012C, YLR013W, YLR023C, YLR112W, YLR221C, YLR261C, YLR262C, YLR286C, YLR413W, YMR017W, YMR056C, YMR135C, YMR135W-A, YMR136W, YMR319C, YNL111C, YNL333W, YNL334C, YNR050C, YNR060W, YNR070W, YOL028C, YOL156W, YOL157C, YOL160W, YOR010C, YOR028C, YOR029W, YOR032C, YOR049C, YOR102W, YOR138C, YOR140W, YOR151C, YOR273C, YOR274W, YOR280C, YOR282W, YOR315W, YPL018W, YPL019C, YPL021W, YPL034W, YPL230W, YPL251W, YPL253C, YPR009W, YPR013C

Genes affected by TF deletion 39 genes

YER013W, YHR146W, YGL166W, YNR060W, YOR220W, YHR179W, YPL016W, YBR098W, YMR316W, YBR093C, YBR129C, YER029C, YKL206C, YLR119W, YOR130C, YGR134W, YLR438C-A, YGL212W, YBR166C, YLR099C, YHR215W, YLR194C, YMR291W, YMR294W-A, YPL156C, YFL014W, YAR071W, YCL025C, YNL065W, YNL036W, YLR416C, YNL289W, YGR137W, YOR052C, YDR322W, YJL196C, YMR038C, YBR244W, YDR333C

Genes supported by both experiments 1 genes

YNR060W

Predicted TF–TF partners 8 genes

GIS1, MIG1, MIG3, RDR1, RGM1, RSC3, RSF2, USV1

Explore 8 original interaction plots →