← All factors / TF RECORD

MOT3

YMR070W, ROX7

View at SGD ↗

Nuclear transcription factor with two Cys2-His2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes

01 / RECOMMENDED MATRIX

Best-performing DNA-binding model.

RecommendedSource: Macisaac et. al
Fisher’s P-value0.001225
Information content8.274
Max PWM score7.16
Recommended cutoff7.16
View and copy the recommended matrices ↘
Position frequency matrix (PFM)
A | 0.329 0.964 0.012 0.012 0.012 0.964 
C | 0.329 0.012 0.012 0.012 0.488 0.012 
G | 0.012 0.012 0.964 0.964 0.012 0.012 
T | 0.329 0.012 0.012 0.012 0.488 0.012 
Position count matrix (PCM)
A |  32  96   1   1   1  96 
C |  32   1   1   1  48   1 
G |   1   1  96  96   1   1 
T |  32   1   1   1  48   1 
Position weight matrix (PWM)
A |  0.03  1.10 -3.28 -3.28 -3.28  1.10 
C |  0.60 -2.71 -2.71 -2.71  1.00 -2.71 
G | -2.71 -2.71  1.68  1.68 -2.71 -2.71 
T |  0.03 -3.28 -3.28 -3.28  0.42 -3.28 
02 / COMPARATIVE BENCHMARKS

Alternative candidate matrices 5

Historical matrix candidates from the original ScerTF database. Expand a source to inspect its original logo, scores, and matrix values.

MOT3_AFoat et. al.P = 0.4861View matrix ↘
Sequence logo for MOT3_A
Fisher’s P-value0.4861
Information content17.47
Max PWM score18.78
Recommended cutoff11.7
Position frequency matrix (PFM)
A | 0.01 0.46 0.01 0.01 0.01 0.04 0.04 0.10 0.23 0.18 0.07 0.01 0.01 0.29 0.31 0.14 
C | 0.66 0.33 0.97 0.73 0.04 0.15 0.19 0.24 0.46 0.38 0.01 0.01 0.94 0.45 0.29 0.73 
G | 0.20 0.15 0.01 0.25 0.94 0.54 0.53 0.30 0.31 0.44 0.80 0.97 0.04 0.23 0.27 0.04 
T | 0.13 0.06 0.01 0.01 0.01 0.26 0.24 0.35 0.01 0.01 0.12 0.01 0.01 0.03 0.13 0.08 
Position count matrix (PCM)
A |   1  46   1   1   1   4   4  10  23  18   7   1   1  28  31  14 
C |  66  33  97  73   4  15  19  24  46  38   1   1  94  45  28  73 
G |  20  15   1  25  94  54  53  30  31  44  80  97   4  23  27   4 
T |  13   6   1   1   1  26  24  35   1   1  12   1   1   3  13   8 
Position weight matrix (PWM)
A | -3.47  0.36 -3.47 -3.47 -3.47 -2.08 -2.08 -1.16 -0.33 -0.58 -1.52 -3.47 -3.47 -0.10 -0.03 -0.83 
C |  1.30  0.61  1.68  1.40 -1.50 -0.18  0.05  0.29  0.94  0.75 -2.89 -2.89  1.65  0.92  0.48  1.40 
G |  0.11 -0.18 -2.89  0.33  1.65  1.10  1.08  0.51  0.54  0.89  1.49  1.68 -1.50  0.25  0.41 -1.50 
T | -0.90 -1.67 -3.47 -3.47 -3.47 -0.21 -0.29  0.09 -3.47 -3.47 -0.98 -3.47 -3.47 -2.37 -0.90 -1.39 
MOT3_BFoat et. al.P = 0.005458View matrix ↘
Sequence logo for MOT3_B
Fisher’s P-value0.005458
Information content16.33
Max PWM score15.73
Recommended cutoff9.12
Position frequency matrix (PFM)
A | 0.19 0.38 0.35 0.94 0.90 0.01 0.04 0.96 0.01 0.02 0.90 0.01 0.30 0.08 0.55 
C | 0.01 0.24 0.01 0.03 0.01 0.01 0.01 0.02 0.05 0.96 0.01 0.01 0.03 0.73 0.13 
G | 0.01 0.07 0.37 0.02 0.01 0.97 0.85 0.01 0.01 0.01 0.07 0.01 0.31 0.01 0.01 
T | 0.80 0.32 0.27 0.01 0.08 0.01 0.10 0.01 0.93 0.01 0.03 0.97 0.36 0.19 0.31 
Position count matrix (PCM)
A |  19  38  35  94  90   1   4  96   1   2  90   1  30   8  55 
C |   1  24   1   3   1   1   1   2   5  96   1   1   3  73  13 
G |   1   7  37   2   1  97  85   1   1   1   7   1  31   1   1 
T |  80  32  27   1   8   1  10   1  93   1   3  97  36  19  31 
Position weight matrix (PWM)
A | -0.52  0.17  0.09  1.08  1.03 -3.47 -2.08  1.10 -3.47 -2.77  1.03 -3.47 -0.06 -1.39  0.54 
C | -2.89  0.29 -2.89 -1.79 -2.89 -2.89 -2.89 -2.20 -1.28  1.67 -2.89 -2.89 -1.79  1.40 -0.33 
G | -2.89 -0.94  0.72 -2.20 -2.89  1.68  1.55 -2.89 -2.89 -2.89 -0.94 -2.89  0.54 -2.89 -2.89 
T |  0.92  0.00 -0.17 -3.47 -1.39 -3.47 -1.16 -3.47  1.07 -3.47 -2.37  1.11  0.12 -0.52 -0.03 
MOT3_CFoat et. al.P = 0.0009932View matrix ↘
Sequence logo for MOT3_C
Fisher’s P-value0.0009932
Information content10.02
Max PWM score9.34
Recommended cutoff8.86
Position frequency matrix (PFM)
A | 0.25 0.19 0.01 0.97 0.52 0.97 0.70 0.76 0.56 
C | 0.50 0.31 0.01 0.01 0.01 0.01 0.28 0.21 0.02 
G | 0.24 0.50 0.97 0.01 0.46 0.01 0.01 0.02 0.41 
T | 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 
Position count matrix (PCM)
A |  25  19   1  97  52  97  70  76  56 
C |  50  31   1   1   1   1  28  21   2 
G |  24  50  97   1  46   1   1   2  41 
T |   1   1   1   1   1   1   1   1   1 
Position weight matrix (PWM)
A | -0.25 -0.52 -3.47  1.11  0.49  1.11  0.78  0.86  0.56 
C |  1.02  0.54 -2.89 -2.89 -2.89 -2.89  0.44  0.15 -2.20 
G |  0.29  1.02  1.68 -2.89  0.94 -2.89 -2.89 -2.20  0.82 
T | -3.47 -3.47 -3.47 -3.47 -3.47 -3.47 -3.47 -3.47 -3.47 
MOT3_DFoat et. al.P = 1View matrix ↘
Sequence logo for MOT3_D
Fisher’s P-value1
Information content19.45
Max PWM score21.78
Recommended cutoff16.34
Position frequency matrix (PFM)
A | 0.25 0.02 0.32 0.01 0.01 0.01 0.06 0.33 0.46 0.01 0.37 0.39 0.03 0.17 0.49 0.21 0.19 0.18 0.23 0.86 0.01 0.96 0.95 0.01 
C | 0.34 0.11 0.14 0.97 0.97 0.90 0.21 0.59 0.01 0.24 0.22 0.01 0.20 0.19 0.24 0.15 0.05 0.19 0.26 0.01 0.01 0.01 0.01 0.08 
G | 0.39 0.28 0.27 0.01 0.01 0.01 0.03 0.07 0.01 0.55 0.40 0.54 0.37 0.26 0.26 0.05 0.54 0.08 0.23 0.02 0.01 0.01 0.03 0.55 
T | 0.02 0.60 0.26 0.01 0.01 0.08 0.70 0.01 0.53 0.20 0.01 0.06 0.39 0.38 0.01 0.58 0.22 0.54 0.28 0.12 0.97 0.02 0.01 0.36 
Position count matrix (PCM)
A |  25   2  32   1   1   1   6  33  46   1  37  39   3  17  49  21  19  18  23  86   1  96  95   1 
C |  34  11  14  97  97  90  21  59   1  24  22   1  20  19  24  15   5  19  26   1   1   1   1   8 
G |  39  28  27   1   1   1   3   7   1  55  40  54  37  26  26   5  54   8  23   2   1   1   3  55 
T |   2  60  26   1   1   8  70   1  53  20   1   6  39  38   1  57  22  54  28  12  97   2   1  36 
Position weight matrix (PWM)
A | -0.25 -2.77  0.00 -3.47 -3.47 -3.47 -1.67  0.03  0.36 -3.47  0.15  0.20 -2.37 -0.63  0.43 -0.42 -0.52 -0.58 -0.33  0.99 -3.47  1.10  1.09 -3.47 
C |  0.64 -0.49 -0.25  1.68  1.68  1.61  0.15  1.19 -2.89  0.29  0.20 -2.89  0.11  0.05  0.29 -0.18 -1.28  0.05  0.37 -2.89 -2.89 -2.89 -2.89 -0.81 
G |  0.77  0.44  0.41 -2.89 -2.89 -2.89 -1.79 -0.94 -2.89  1.12  0.80  1.10  0.72  0.37  0.37 -1.28  1.10 -0.81  0.25 -2.20 -2.89 -2.89 -1.79  1.12 
T | -2.77  0.63 -0.21 -3.47 -3.47 -1.39  0.78 -3.47  0.50 -0.47 -3.47 -1.67  0.20  0.17 -3.47  0.59 -0.37  0.52 -0.13 -0.98  1.11 -2.77 -3.47  0.12 
MOT3Harbison et. al.P = 0.001225View matrix ↘
Sequence logo for MOT3
Fisher’s P-value0.001225
Information content8.282
Max PWM score7.16
Recommended cutoff7.16
Position frequency matrix (PFM)
A | 0.329 0.964 0.012 0.012 0.012 0.964 
C | 0.329 0.012 0.012 0.012 0.488 0.012 
G | 0.012 0.012 0.965 0.965 0.012 0.012 
T | 0.329 0.012 0.012 0.012 0.488 0.012 
Position count matrix (PCM)
A |  32  96   1   1   1  96 
C |  32   1   1   1  48   1 
G |   1   1  96  96   1   1 
T |  32   1   1   1  48   1 
Position weight matrix (PWM)
A |  0.03  1.10 -3.28 -3.28 -3.28  1.10 
C |  0.60 -2.71 -2.71 -2.71  1.00 -2.71 
G | -2.71 -2.71  1.68  1.68 -2.71 -2.71 
T |  0.03 -3.28 -3.28 -3.28  0.42 -3.28 
03 / EXPERIMENTAL CONTEXT

Gene-level annotations and interactions.

Genes bound in ChIP-chip experiments 63 genes

YAL004W, YAL059W, YAR047C, YAR073W, YAR075W, YBL020W, YBL021C, YBL022C, YBL029W, YBR012C, YBR012W-A, YBR012W-B, YBR013C, YBR032W, YBR056W, YBR083W, YBR089C-A, YBR090C, YBR097W, YBR105C, YBR106W, YBR119W, YBR210W, YBR275C, YBR294W, YDL044C, YDL063C, YDR022C, YDR023W, YDR065W, YDR278C, YDR339C, YDR340W, YDR420W, YEL055C, YEL069C, YEL070W, YER137C, YFR016C, YGL005C, YGL190C, YHR185C, YIL095W, YIL096C, YIL099W, YIL119C, YIR020C, YJL022W, YJL148W, YJL162C, YJR158W, YJR159W, YKL127W, YKL165C, YKR073C, YLR035C, YML071C, YMR106C, YOL022C, YOL121C, YOR042W, YPL130W, YPR072W

Genes affected by TF deletion 163 genes

YCL055W, YHL044W, YIL080W, YAL068C, YDL131W, YGL039W, YGL009C, YFR036W, YLR056W, YLR461W, YLR432W, YOR065W, YPL049C, YIL082W, YJR047C, YLR219W, YMR013C, YMR015C, YOR252W, YPL240C, YBR157C, YLR089C, YLR435W, YOR032C, YPL016W, YER011W, YBR092C, YHR081W, YIL176C, YOL136C, YOR287C, YPL283C, YCL017C, YML083C, YML058W-A, YNR028W, YNL307C, YMR070W, YMR102C, YOR318C, YDR281C, YGR211W, YNL300W, YBL093C, YBR012C, YCR048W, YCR050C, YDR044W, YNL024C, YNR071C, YDR196C, YLR068W, YMR173W, YNL279W, YOR043W, YDR077W, YIL121W, YBR196C, YLR037C, YLR437C, YOR010C, YFL020C, YFR015C, YIR042C, YJR151C, YLR348C, YMR145C, YOL150C, YBR293W, YHR215W, YJL217W, YJL223C, YPL092W, YJR150C, YJR121W, YLR349W, YOL143C, YPL137C, YAR071W, YAR075W, YBR290W, YCL027W, YGR221C, YHR216W, YJL216C, YJL218W, YKL150W, YNR001C, YBL099W, YGR294W, YNR073C, YPL189W, YIL114C, YBR177C, YGL029W, YLR042C, YBL100C, YMR056C, YML130C, YNL094W, YNR072W, YNR076W, YOR236W, YEL059C-A, YGR108W, YGR109W-A, YMR173W-A, YOR084W, YOR394W, YGR049W, YJR159W, YOL122C, YBR301W, YLR202C, YMR272C, YDR481C, YFR018C, YGR078C, YIR018W, YJR158W, YLR353W, YOL119C, YOL151W, YDL241W, YDR297W, YER044C, YNR044W, YER168C, YMR037C, YAL060W, YDR268W, YEL065W, YEL038W, YHR136C, YOR095C, YGL255W, YMR038C, YNL104C, YBR210W, YEL068C, YGL032C, YHR137W, YKL096W-A, YLR113W, YLR452C, YBR085W, YCR104W, YNL167C, YBL051C, YIL011W, YKL164C, YML047C, YPL106C, YGR086C, YLL019C, YOL161C, YOL101C, YOR372C, YPR009W, YGL162W, YJL170C, YLR179C, YMR307W

Genes supported by both experiments 5 genes

YAR075W, YBR012C, YBR210W, YJR158W, YJR159W