← All factors / TF RECORD
MET4
YNL103W
Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
01 / RECOMMENDED MATRIX
Best-performing DNA-binding model.
Fisher’s P-value2.07e-14
Information content18.33
Max PWM score16.01
Recommended cutoff11.18
View and copy the recommended matrices ↘
Position frequency matrix (PFM)
A | 0.697 0.797 0.697 0.899 0.604 0.396 0.001 0.001 0.001 0.001 0.103 0.001 0.001 0.097 0.101 C | 0.001 0.201 0.203 0.001 0.001 0.303 0.001 0.001 0.001 0.195 0.101 0.401 0.001 0.501 0.598 G | 0.303 0.002 0.101 0.100 0.001 0.301 0.001 0.999 0.295 0.804 0.796 0.001 0.999 0.301 0.001 T | 0.001 0.001 0.001 0.001 0.396 0.001 0.999 0.001 0.704 0.001 0.001 0.598 0.001 0.101 0.301
Position count matrix (PCM)
A | 69 79 69 89 60 39 0 0 0 0 10 0 0 9 10 C | 0 20 20 0 0 30 0 0 0 19 10 40 0 50 59 G | 30 0 10 10 0 30 0 99 29 80 79 0 99 30 0 T | 0 0 0 0 39 0 99 0 70 0 0 59 0 10 30
Position weight matrix (PWM)
A | 0.78 0.91 0.78 1.03 0.64 0.21 -5.77 -5.77 -5.77 -5.77 -1.13 -5.77 -5.77 -1.19 -1.15 C | -5.19 0.11 0.12 -5.19 -5.19 0.52 -5.19 -5.19 -5.19 0.08 -0.58 0.80 -5.19 1.02 1.20 G | 0.52 -4.50 -0.58 -0.59 -5.19 0.51 -5.19 1.71 0.49 1.50 1.49 -5.19 1.71 0.51 -5.19 T | -5.77 -5.77 -5.77 -5.77 0.21 -5.77 1.14 -5.77 0.79 -5.77 -5.77 0.63 -5.77 -1.15 -0.06
02 / COMPARATIVE BENCHMARKS
Alternative candidate matrices 5
Historical matrix candidates from the original ScerTF database. Expand a source to inspect its original logo, scores, and matrix values.
MET4_AFoat et. al.P = 8.24e-08View matrix ↘
Fisher’s P-value8.24e-08
Information content17.17
Max PWM score15.07
Recommended cutoff9.41
Position frequency matrix (PFM)
A | 0.29 0.03 0.01 0.13 0.52 0.01 0.02 0.07 0.01 0.97 0.01 0.01 C | 0.01 0.03 0.02 0.85 0.01 0.97 0.01 0.01 0.07 0.01 0.90 0.34 G | 0.62 0.01 0.36 0.01 0.02 0.01 0.96 0.01 0.91 0.01 0.01 0.65 T | 0.08 0.93 0.62 0.01 0.45 0.01 0.01 0.92 0.01 0.01 0.08 0.01
Position count matrix (PCM)
A | 28 3 1 13 52 1 2 7 1 97 1 1 C | 1 3 2 85 1 97 1 1 7 1 90 34 G | 62 1 36 1 2 1 96 1 91 1 1 65 T | 8 93 62 1 45 1 1 92 1 1 8 1
Position weight matrix (PWM)
A | -0.10 -2.37 -3.47 -0.90 0.49 -3.47 -2.77 -1.52 -3.47 1.11 -3.47 -3.47 C | -2.89 -1.79 -2.20 1.55 -2.89 1.68 -2.89 -2.89 -0.94 -2.89 1.61 0.64 G | 1.24 -2.89 0.69 -2.89 -2.20 -2.89 1.67 -2.89 1.62 -2.89 -2.89 1.28 T | -1.39 1.07 0.66 -3.47 0.34 -3.47 -3.47 1.06 -3.47 -3.47 -1.39 -3.47
MET4_BFoat et. al.P = 0.0001776View matrix ↘
Fisher’s P-value0.0001776
Information content15.3
Max PWM score15.35
Recommended cutoff11.32
Position frequency matrix (PFM)
A | 0.56 0.25 0.06 0.01 0.70 0.01 0.02 0.01 0.20 0.11 0.04 0.18 C | 0.02 0.01 0.20 0.97 0.01 0.97 0.16 0.01 0.01 0.49 0.88 0.75 G | 0.01 0.72 0.56 0.01 0.02 0.01 0.82 0.01 0.79 0.17 0.07 0.03 T | 0.41 0.02 0.18 0.01 0.27 0.01 0.01 0.97 0.01 0.23 0.01 0.04
Position count matrix (PCM)
A | 56 25 6 1 70 1 2 1 20 11 4 18 C | 2 1 20 97 1 97 16 1 1 49 88 75 G | 1 72 56 1 2 1 82 1 79 17 7 3 T | 41 2 18 1 27 1 1 97 1 23 1 4
Position weight matrix (PWM)
A | 0.56 -0.25 -1.67 -3.47 0.78 -3.47 -2.77 -3.47 -0.47 -1.07 -2.08 -0.58 C | -2.20 -2.89 0.11 1.68 -2.89 1.68 -0.12 -2.89 -2.89 1.00 1.59 1.43 G | -2.89 1.39 1.13 -2.89 -2.20 -2.89 1.52 -2.89 1.48 -0.06 -0.94 -1.79 T | 0.25 -2.77 -0.58 -3.47 -0.17 -3.47 -3.47 1.11 -3.47 -0.33 -3.47 -2.08
MET4Macisaac et. alP = 6.40e-07View matrix ↘
Fisher’s P-value6.40e-07
Information content14.04
Max PWM score10.58
Recommended cutoff8.52
Position frequency matrix (PFM)
A | 0.997 0.665 0.003 0.001 0.001 0.001 0.001 0.001 C | 0.001 0.166 0.663 0.001 0.001 0.001 0.001 0.001 G | 0.001 0.168 0.001 0.001 0.997 0.001 0.997 0.997 T | 0.001 0.001 0.333 0.997 0.001 0.997 0.001 0.001
Position count matrix (PCM)
A | 99 66 0 0 0 0 0 0 C | 0 16 66 0 0 0 0 0 G | 0 16 0 0 99 0 99 99 T | 0 0 33 99 0 99 0 0
Position weight matrix (PWM)
A | 1.14 0.73 -4.67 -5.77 -5.77 -5.77 -5.77 -5.77 C | -5.19 -0.08 1.30 -5.19 -5.19 -5.19 -5.19 -5.19 G | -5.19 -0.07 -5.19 -5.19 1.71 -5.19 1.71 1.71 T | -5.77 -5.77 0.04 1.14 -5.77 1.14 -5.77 -5.77
MET4_AMorozov et. al.P = 8.18e-07View matrix ↘
Fisher’s P-value8.18e-07
Information content8.934
Max PWM score9.05
Recommended cutoff7.55
Position frequency matrix (PFM)
A | 0.056 0.067 0.950 0.022 0.055 0.038 0.063 C | 0.114 0.701 0.036 0.926 0.066 0.014 0.073 G | 0.026 0.087 0.006 0.025 0.853 0.106 0.817 T | 0.804 0.145 0.009 0.027 0.027 0.842 0.047
Position count matrix (PCM)
A | 5 6 95 2 5 3 6 C | 11 70 3 92 6 1 7 G | 2 8 0 2 85 10 81 T | 80 14 0 2 2 84 4
Position weight matrix (PWM)
A | -1.74 -1.56 1.09 -2.68 -1.76 -2.13 -1.63 C | -0.46 1.36 -1.61 1.64 -1.00 -2.55 -0.90 G | -1.93 -0.73 -3.40 -1.97 1.56 -0.53 1.51 T | 0.92 -0.79 -3.57 -2.47 -2.47 0.97 -1.92
MET4_BMorozov et. al.P = 6.75e-07View matrix ↘
Fisher’s P-value6.75e-07
Information content8.866
Max PWM score9.85
Recommended cutoff8.05
Position frequency matrix (PFM)
A | 0.286 0.050 0.153 0.854 0.011 0.038 0.100 0.054 0.749 C | 0.070 0.035 0.608 0.047 0.945 0.018 0.211 0.426 0.169 G | 0.599 0.084 0.128 0.076 0.025 0.916 0.177 0.440 0.041 T | 0.045 0.831 0.111 0.023 0.018 0.028 0.512 0.080 0.041
Position count matrix (PCM)
A | 28 5 15 85 1 3 10 5 74 C | 7 3 60 4 94 1 21 42 16 G | 59 8 12 7 2 91 17 44 4 T | 4 83 11 2 1 2 51 8 4
Position weight matrix (PWM)
A | -0.11 -1.86 -0.74 0.98 -3.37 -2.13 -1.16 -1.78 0.85 C | -0.94 -1.64 1.22 -1.34 1.66 -2.30 0.16 0.86 -0.06 G | 1.20 -0.76 -0.34 -0.86 -1.97 1.63 -0.02 0.89 -1.48 T | -1.96 0.95 -1.06 -2.63 -2.88 -2.44 0.47 -1.39 -2.05
03 / EXPERIMENTAL CONTEXT
Gene-level annotations and interactions.
Genes bound in ChIP-chip experiments 58 genes
YAL012W, YBR011C, YBR077C, YBR078W, YDL024C, YDL058W, YDL059C, YER092W, YFR030W, YFR031C, YFR035C, YGL184C, YGR055W, YGR060W, YGR157W, YGR204W, YGR239C, YHR136C, YHR137W, YIL074C, YIR007W, YIR017C, YIR018W, YJL048C, YJL078C, YJL100W, YJL101C, YJL210W, YJL212C, YKL001C, YKR073C, YLL037W, YLL039C, YLL044W, YLL046C, YLR092W, YLR179C, YLR180W, YLR213C, YLR214W, YLR431C, YLR432W, YMR070W, YNL016W, YNL017C, YNL030W, YNL031C, YNL034W, YNL097C, YNL220W, YNL221C, YNL277W, YOR136W, YOR236W, YPL164C, YPL198W, YPR170C, YPR171W
Genes affected by TF deletion 1 genes
No Data
Predicted TF–TF partners 3 genes
CBF1, MET32, TYE7