S.ScerTFYeast transcription factor database Aaron Spivak
← All factors / TF RECORD

MET32

YDR253C

View at SGD ↗

Zinc-finger DNA-binding protein, involved in transcriptional regulation of the methionine biosynthetic genes, similar to Met31p

01 / RECOMMENDED MATRIX

Best-performing DNA-binding model.

RecommendedSource: Macisaac et. al
Fisher’s P-value2.05e-09
Information content15.53
Max PWM score12.65
Recommended cutoff8.91
View and copy the recommended matrices ↘
Position frequency matrix (PFM)
A | 0.514 0.912 0.685 0.029 0.001 0.001 0.001 0.001 0.001 0.001 
C | 0.314 0.001 0.001 0.629 0.001 0.001 0.001 0.001 0.001 0.912 
G | 0.029 0.001 0.200 0.171 0.001 0.997 0.001 0.997 0.997 0.001 
T | 0.143 0.086 0.114 0.171 0.997 0.001 0.997 0.001 0.001 0.086
Position count matrix (PCM)
A |  51  91  68   2   0   0   0   0   0   0 
C |  31   0   0  62   0   0   0   0   0  91 
G |   2   0  20  17   0  99   0  99  99   0 
T |  14   8  11  17  99   0  99   0   0   8
Position weight matrix (PWM)
A |  0.47  1.05  0.76 -2.40 -5.77 -5.77 -5.77 -5.77 -5.77 -5.77 
C |  0.56 -5.19 -5.19  1.25 -5.19 -5.19 -5.19 -5.19 -5.19  1.62 
G | -1.83 -5.19  0.11 -0.05 -5.19  1.71 -5.19  1.71  1.71 -5.19 
T | -0.81 -1.31 -1.03 -0.63  1.14 -5.77  1.14 -5.77 -5.77 -1.31
02 / COMPARATIVE BENCHMARKS

Alternative candidate matrices 10

Historical matrix candidates from the original ScerTF database. Expand a source to inspect its original logo, scores, and matrix values.

MET32Badis et. al.P = 0.0001896View matrix ↘
Sequence logo for MET32
Fisher’s P-value0.0001896
Information content9.421
Max PWM score8.25
Recommended cutoff8.25
Position frequency matrix (PFM)
A | 0.11 0.01 0.01 0.93 0.01 0.64 
C | 0.05 0.97 0.97 0.03 0.97 0.15 
G | 0.77 0.01 0.01 0.01 0.01 0.12 
T | 0.07 0.01 0.01 0.03 0.01 0.09
Position count matrix (PCM)
A |  11   1   1  93   1  64 
C |   5  97  97   3  97  15 
G |  77   1   1   1   1  12 
T |   7   1   1   3   1   9
Position weight matrix (PWM)
A | -1.07 -3.47 -3.47  1.07 -3.47  0.69 
C | -1.28  1.68  1.68 -1.79  1.68 -0.18 
G |  1.45 -2.89 -2.89 -2.89 -2.89 -0.41 
T | -1.52 -3.47 -3.47 -2.37 -3.47 -1.27
Badis et. al.
MET32_AFoat et. al.P = 2.28e-08View matrix ↘
Sequence logo for MET32_A
Fisher’s P-value2.28e-08
Information content14.61
Max PWM score14.54
Recommended cutoff10.81
Position frequency matrix (PFM)
A | 0.17 0.33 0.26 0.01 0.01 0.02 0.91 0.42 0.07 0.08 0.01 0.07 
C | 0.45 0.01 0.03 0.01 0.86 0.96 0.07 0.56 0.91 0.60 0.15 0.01 
G | 0.35 0.04 0.63 0.01 0.12 0.01 0.01 0.01 0.01 0.28 0.16 0.87 
T | 0.03 0.63 0.08 0.97 0.01 0.01 0.01 0.01 0.01 0.05 0.69 0.05
Position count matrix (PCM)
A |  17  33  26   1   1   2  91  42   7   8   1   7 
C |  45   1   3   1  86  96   7  56  91  60  15   1 
G |  35   4  63   1  12   1   1   1   1  28  16  87 
T |   3  63   8  97   1   1   1   1   1   5  69   5
Position weight matrix (PWM)
A | -0.63  0.03 -0.21 -3.47 -3.47 -2.77  1.05  0.27 -1.52 -1.39 -3.47 -1.52 
C |  0.92 -2.89 -1.79 -2.89  1.56  1.67 -0.94  1.13  1.62  1.20 -0.18 -2.89 
G |  0.66 -1.50  1.25 -2.89 -0.41 -2.89 -2.89 -2.89 -2.89  0.44 -0.12  1.58 
T | -2.37  0.68 -1.39  1.11 -3.47 -3.47 -3.47 -3.47 -3.47 -1.86  0.77 -1.86
Foat et. al.
MET32_BFoat et. al.P = 4.54e-10View matrix ↘
Sequence logo for MET32_B
Fisher’s P-value4.54e-10
Information content17.59
Max PWM score16.14
Recommended cutoff9.67
Position frequency matrix (PFM)
A | 0.55 0.88 0.07 0.01 0.97 0.01 0.01 0.04 0.01 0.97 0.17 0.37 0.01 
C | 0.27 0.01 0.83 0.93 0.01 0.97 0.01 0.51 0.01 0.01 0.20 0.04 0.01 
G | 0.06 0.11 0.03 0.01 0.01 0.01 0.97 0.10 0.97 0.01 0.41 0.59 0.01 
T | 0.12 0.01 0.06 0.05 0.01 0.01 0.01 0.36 0.01 0.01 0.22 0.01 0.97
Position count matrix (PCM)
A |  55  88   7   1  97   1   1   4   1  97  17  37   1 
C |  27   1  83  93   1  97   1  51   1   1  20   4   1 
G |   6  11   3   1   1   1  97  10  97   1  41  59   1 
T |  12   1   6   5   1   1   1  36   1   1  22   1  97
Position weight matrix (PWM)
A |  0.54  1.01 -1.52 -3.47  1.11 -3.47 -3.47 -2.08 -3.47  1.11 -0.63  0.15 -3.47 
C |  0.41 -2.89  1.53  1.64 -2.89  1.68 -2.89  1.04 -2.89 -2.89  0.11 -1.50 -2.89 
G | -1.10 -0.49 -1.79 -2.89 -2.89 -2.89  1.68 -0.59  1.68 -2.89  0.82  1.19 -2.89 
T | -0.98 -3.47 -1.67 -1.86 -3.47 -3.47 -3.47  0.12 -3.47 -3.47 -0.37 -3.47  1.11
Foat et. al.
MET32_AFordyce et. al.P = 2.40e-05View matrix ↘
Fisher’s P-value2.40e-05
Information content7.676
Max PWM score8.68
Recommended cutoff8.68
Position frequency matrix (PFM)
A | 0.12 0.14 0.01 0.87 0.02 0.64 0.31 0.23 
C | 0.12 0.76 0.97 0.02 0.89 0.09 0.27 0.24 
G | 0.56 0.10 0.01 0.04 0.01 0.11 0.36 0.02 
T | 0.20 0.01 0.01 0.08 0.07 0.16 0.06 0.50
Position count matrix (PCM)
A |  12  14   1  87   2  64  31  23 
C |  12  76  97   2  89   9  27  24 
G |  56  10   1   4   1  11  36   2 
T |  20   1   1   8   7  16   6  50
Position weight matrix (PWM)
A | -0.98 -0.83 -3.47  1.00 -2.77  0.69 -0.03 -0.33 
C | -0.41  1.44  1.68 -2.20  1.60 -0.69  0.41  0.29 
G |  1.13 -0.59 -2.89 -1.50 -2.89 -0.49  0.69 -2.20 
T | -0.47 -3.47 -3.47 -1.39 -1.52 -0.69 -1.67  0.45
Fordyce et. al.
MET32_BFordyce et. al.P = 0.0004039View matrix ↘
Fisher’s P-value0.0004039
Information content7.663
Max PWM score8.69
Recommended cutoff6.39
Position frequency matrix (PFM)
A | 0.13 0.01 0.86 0.02 0.64 0.31 0.25 0.12 
C | 0.74 0.97 0.02 0.90 0.09 0.27 0.23 0.10 
G | 0.12 0.01 0.04 0.01 0.11 0.36 0.03 0.58 
T | 0.01 0.01 0.08 0.07 0.16 0.06 0.50 0.20
Position count matrix (PCM)
A |  13   1  86   2  64  31  25  12 
C |  74  97   2  90   9  27  23  10 
G |  12   1   4   1  11  36   3  57 
T |   1   1   8   7  16   6  50  20
Position weight matrix (PWM)
A | -0.90 -3.47  0.99 -2.77  0.69 -0.03 -0.25 -0.98 
C |  1.41  1.68 -2.20  1.61 -0.69  0.41  0.25 -0.59 
G | -0.41 -2.89 -1.50 -2.89 -0.49  0.69 -1.79  1.17 
T | -3.47 -3.47 -1.39 -1.52 -0.69 -1.67  0.45 -0.47
Fordyce et. al.
MET32_CFordyce et. al.P = 0.0001607View matrix ↘
Fisher’s P-value0.0001607
Information content8.098
Max PWM score9.2
Recommended cutoff7.03
Position frequency matrix (PFM)
A | 0.27 0.19 0.12 0.10 0.01 0.90 0.03 0.67 
C | 0.24 0.35 0.09 0.79 0.97 0.01 0.88 0.07 
G | 0.41 0.02 0.60 0.10 0.01 0.04 0.01 0.11 
T | 0.08 0.44 0.19 0.01 0.01 0.05 0.08 0.15
Position count matrix (PCM)
A |  27  19  12  10   1  90   3  67 
C |  24  35   9  79  97   1  88   7 
G |  41   2  60  10   1   4   1  11 
T |   8  44  19   1   1   5   8  15
Position weight matrix (PWM)
A | -0.17 -0.52 -0.98 -1.16 -3.47  1.03 -2.37  0.74 
C |  0.29  0.66 -0.69  1.48  1.68 -2.89  1.59 -0.94 
G |  0.82 -2.20  1.20 -0.59 -2.89 -1.50 -2.89 -0.49 
T | -1.39  0.32 -0.52 -3.47 -3.47 -1.86 -1.39 -0.76
Fordyce et. al.
MET32Harbison et. al.P = 2.07e-05View matrix ↘
Sequence logo for MET32
Fisher’s P-value2.07e-05
Information content15.64
Max PWM score12.22
Recommended cutoff8.41
Position frequency matrix (PFM)
A | 0.965 0.965 0.965 0.012 0.012 0.012 0.012 0.012 0.012 
C | 0.012 0.012 0.012 0.965 0.012 0.012 0.012 0.012 0.012 
G | 0.012 0.012 0.012 0.012 0.012 0.965 0.012 0.965 0.965 
T | 0.012 0.012 0.012 0.012 0.965 0.012 0.965 0.012 0.012
Position count matrix (PCM)
A |  96  96  96   1   1   1   1   1   1 
C |   1   1   1  96   1   1   1   1   1 
G |   1   1   1   1   1  96   1  96  96 
T |   1   1   1   1  96   1  96   1   1
Position weight matrix (PWM)
A |  1.10  1.10  1.10 -3.28 -3.28 -3.28 -3.28 -3.28 -3.28 
C | -2.71 -2.71 -2.71  1.68 -2.71 -2.71 -2.71 -2.71 -2.71 
G | -2.71 -2.71 -2.71 -2.71 -2.71  1.68 -2.71  1.68  1.68 
T | -3.28 -3.28 -3.28 -3.28  1.10 -3.28  1.10 -3.28 -3.28
Harbison et. al.
MET32Pachkov et alP = 1.51e-06View matrix ↘
Sequence logo for MET32
Fisher’s P-value1.51e-06
Information content13.45
Max PWM score11.28
Recommended cutoff9.85
Position frequency matrix (PFM)
A | 0.543 0.809 0.966 0.087 0.012 0.001 0.001 0.001 0.142 
C | 0.175 0.109 0.001 0.876 0.034 0.046 0.018 0.001 0.003 
G | 0.156 0.082 0.034 0.002 0.001 0.954 0.001 1.000 0.849 
T | 0.126 0.001 0.001 0.034 0.954 0.001 0.982 0.001 0.006
Position count matrix (PCM)
A |  54  80  96   8   1   0   0   0  14 
C |  17  10   0  87   3   4   1   0   0 
G |  15   8   3   0   0  95   0 100  84 
T |  12   0   0   3  95   0  98   0   0
Position weight matrix (PWM)
A |  0.53  0.93  1.10 -1.30 -3.28 -5.77 -5.77 -5.77 -0.81 
C | -0.03 -0.50 -5.19  1.58 -1.67 -1.36 -2.30 -5.19 -4.09 
G | -0.14 -0.79 -1.67 -4.50 -5.19  1.67 -5.19  1.71  1.55 
T | -0.93 -5.77 -5.77 -2.24  1.09 -5.77  1.12 -5.77 -3.98
Pachkov et al
MET32Zhu et. al.P = 4.28e-06View matrix ↘
Sequence logo for MET32
Fisher’s P-value4.28e-06
Information content15.52
Max PWM score13.46
Recommended cutoff9.85
Position frequency matrix (PFM)
A | 0.75 0.07 0.01 0.02 0.01 0.01 0.01 0.01 0.02 0.01 
C | 0.02 0.40 0.01 0.01 0.01 0.01 0.01 0.97 0.01 0.61 
G | 0.16 0.46 0.01 0.96 0.01 0.97 0.97 0.01 0.82 0.06 
T | 0.08 0.08 0.97 0.01 0.97 0.01 0.01 0.01 0.15 0.33
Position count matrix (PCM)
A |  75   7   1   2   1   1   1   1   2   1 
C |   2  40   1   1   1   1   1  97   1  61 
G |  16  46   1  96   1  97  97   1  82   6 
T |   8   8  97   1  97   1   1   1  15  33
Position weight matrix (PWM)
A |  0.85 -1.52 -3.47 -2.77 -3.47 -3.47 -3.47 -3.47 -2.77 -3.47 
C | -2.20  0.80 -2.89 -2.89 -2.89 -2.89 -2.89  1.68 -2.89  1.22 
G | -0.12  0.94 -2.89  1.67 -2.89  1.68  1.68 -2.89  1.52 -1.10 
T | -1.39 -1.39  1.11 -3.47  1.11 -3.47 -3.47 -3.47 -0.76  0.03
Zhu et. al.
MET32Zhao and StormoP = 0.0001419View matrix ↘
Sequence logo for MET32
Fisher’s P-value0.0001419
Information content8.082
Max PWM score8.72
Recommended cutoff7.59
Position frequency matrix (PFM)
A | 0.131 0.096 0.100 0.001 0.020 0.111 0.141 
C | 0.153 0.011 0.103 0.025 0.001 0.740 0.080 
G | 0.136 0.868 0.075 0.955 0.941 0.047 0.494 
T | 0.580 0.025 0.723 0.020 0.038 0.102 0.285
Position count matrix (PCM)
A |  13   9  10   0   2  11  14 
C |  15   1  10   2   0  74   8 
G |  13  86   7  95  94   4  49 
T |  57   2  72   2   3  10  28
Position weight matrix (PWM)
A | -0.89 -1.20 -1.16 -5.77 -2.77 -1.06 -0.82 
C | -0.16 -2.80 -0.56 -1.97 -5.19  1.41 -0.81 
G | -0.28  1.57 -0.88  1.67  1.65 -1.34  1.01 
T |  0.59 -2.55  0.82 -2.77 -2.13 -1.14 -0.12
Zhao and Stormo
03 / EXPERIMENTAL CONTEXT

Gene-level annotations and interactions.

Genes bound in ChIP-chip experiments 154 genes

YAL012W, YAL016W, YAL034W-A, YAL035C-A, YAL035W, YAL036C, YAR009C, YBL025W, YBL089W, YBR011C, YBR019C, YBR020W, YBR127C, YBR150C, YBR151W, YBR167C, YBR168W, YBR187W, YBR213W, YBR214W, YCR020C-A, YCR028C, YCR081W, YCR106W, YDL058W, YDL059C, YDL132W, YDR048C, YDR142C, YDR179C, YDR179W-A, YDR207C, YDR208W, YDR210W-D, YDR256C, YDR372C, YDR373W, YDR472W, YDR523C, YEL004W, YEL005C, YEL011W, YEL072W, YER007C-A, YER015W, YER049W, YER070W, YER091C, YER092W, YER134C, YER138C, YFR015C, YFR030W, YGL133W, YGL134W, YGL143C, YGL148W, YGL150C, YGL172W, YGL173C, YGL184C, YGL201C, YGL235W, YGL237C, YGR109C, YGR109W-A, YGR109W-B, YGR145W, YGR150C, YGR177C, YGR187C, YGR188C, YGR204W, YGR206W, YGR218W, YHL017W, YHR117W, YHR156C, YHR157W, YIL014W, YIL069C, YIL100W, YIL101C, YIL113W, YIL114C, YIL120W, YJL023C, YJL060W, YJL148W, YJR010W, YJR045C, YJR046W, YJR069C, YJR071W, YJR100C, YJR137C, YJR138W, YKL039W, YKL040C, YKL153W, YKL178C, YKL202W, YKL203C, YKR036C, YKR096W, YLR011W, YLR046C, YLR089C, YLR090W, YLR092W, YLR174W, YLR176C, YLR177W, YLR179C, YLR180W, YLR186W, YLR221C, YLR303W, YLR373C, YLR375W, YLR428C, YLR430W, YML072C, YMR043W, YMR065W, YMR194W, YMR260C, YNL006W, YNL007C, YNL113W, YNL115C, YNL146W, YNL232W, YNL258C, YNL277W, YNL299W, YNL321W, YNL322C, YNR006W, YNR054C, YOL041C, YOL064C, YOL083W, YOR093C, YOR094W, YOR106W, YOR297C, YOR298W, YPL262W, YPL263C, YPR158W-A, YPR158W-B, YPR167C, YPR168W

Genes affected by TF deletion 14 genes

YKR039W, YMR040W, YDR193W, YDR253C, YPL016W, YLL034C, YMR111C, YOL002C, YLR078C, YNL133C, YIL134W, YPL076W, YMR034C, YDL183C

Predicted TF–TF partners 4 genes

CBF1, MET4, PHO4, TYE7

Explore 4 original interaction plots →