← All factors / TF RECORD
LEU3
YLR451W
Zinc-finger transcription factor that regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; positively regulated by alpha-isopropylmalate, an intermediate in leucine biosynthesis
01 / RECOMMENDED MATRIX
Best-performing DNA-binding model.
Fisher’s P-value2.57e-21
Information content13.09
Max PWM score13.53
Recommended cutoff9.97
View and copy the recommended matrices ↘
Position frequency matrix (PFM)
A | 0.054 0.019 0.025 0.048 0.309 0.729 0.146 0.048 0.025 0.034 C | 0.750 0.919 0.026 0.040 0.065 0.057 0.722 0.894 0.053 0.036 G | 0.150 0.035 0.880 0.793 0.152 0.072 0.080 0.031 0.881 0.898 T | 0.045 0.027 0.068 0.118 0.474 0.143 0.053 0.026 0.042 0.032
Position count matrix (PCM)
A | 5 1 2 4 30 72 14 4 2 3 C | 75 91 2 4 6 5 72 89 5 3 G | 15 3 88 79 15 7 8 3 88 89 T | 4 2 6 11 47 14 5 2 4 3
Position weight matrix (PWM)
A | -1.78 -2.82 -2.55 -1.90 -0.03 0.82 -0.78 -1.90 -2.55 -2.24 C | 1.43 1.63 -1.93 -1.50 -1.02 -1.15 1.39 1.60 -1.22 -1.61 G | -0.18 -1.64 1.59 1.48 -0.17 -0.92 -0.81 -1.76 1.59 1.61 T | -1.96 -2.47 -1.55 -1.00 0.39 -0.81 -1.80 -2.51 -2.03 -2.30
02 / COMPARATIVE BENCHMARKS
Alternative candidate matrices 9
Historical matrix candidates from the original ScerTF database. Expand a source to inspect its original logo, scores, and matrix values.
LEU3Badis et. al.P = 2.98e-13View matrix ↘
Fisher’s P-value2.98e-13
Information content13.36
Max PWM score12.01
Recommended cutoff10.06
Position frequency matrix (PFM)
A | 0.01 0.01 0.01 0.20 0.25 0.47 0.01 0.01 0.01 0.01 C | 0.97 0.97 0.01 0.01 0.33 0.12 0.60 0.97 0.01 0.31 G | 0.01 0.01 0.56 0.35 0.01 0.16 0.38 0.01 0.97 0.67 T | 0.01 0.01 0.42 0.45 0.40 0.25 0.01 0.01 0.01 0.01
Position count matrix (PCM)
A | 1 1 1 20 25 47 1 1 1 1 C | 97 97 1 1 33 12 60 97 1 31 G | 1 1 56 35 1 16 38 1 97 67 T | 1 1 42 45 40 25 1 1 1 1
Position weight matrix (PWM)
A | -3.47 -3.47 -3.47 -0.47 -0.25 0.38 -3.47 -3.47 -3.47 -3.47 C | 1.68 1.68 -2.89 -2.89 0.61 -0.41 1.20 1.68 -2.89 0.54 G | -2.89 -2.89 1.13 0.66 -2.89 -0.12 0.75 -2.89 1.68 1.31 T | -3.47 -3.47 0.27 0.34 0.22 -0.25 -3.47 -3.47 -3.47 -3.47
LEU3_AFoat et. al.P = 7.93e-16View matrix ↘
Fisher’s P-value7.93e-16
Information content12.43
Max PWM score13.79
Recommended cutoff9.99
Position frequency matrix (PFM)
A | 0.04 0.03 0.37 0.01 0.01 0.07 0.04 0.43 0.34 0.22 0.17 0.05 0.01 0.56 C | 0.10 0.11 0.31 0.94 0.85 0.10 0.15 0.14 0.16 0.40 0.53 0.18 0.24 0.10 G | 0.41 0.31 0.20 0.04 0.13 0.81 0.75 0.13 0.21 0.38 0.30 0.76 0.75 0.06 T | 0.45 0.55 0.12 0.01 0.01 0.02 0.06 0.31 0.29 0.01 0.01 0.01 0.01 0.29
Position count matrix (PCM)
A | 4 3 37 1 1 7 4 43 34 22 17 5 1 56 C | 10 11 31 94 85 10 15 14 16 40 53 18 24 10 G | 41 31 20 4 13 81 75 13 21 38 30 76 75 6 T | 45 55 12 1 1 2 6 31 28 1 1 1 1 28
Position weight matrix (PWM)
A | -2.08 -2.37 0.15 -3.47 -3.47 -1.52 -2.08 0.30 0.06 -0.37 -0.63 -1.86 -3.47 0.56 C | -0.59 -0.49 0.54 1.65 1.55 -0.59 -0.18 -0.25 -0.12 0.80 1.08 0.00 0.29 -0.59 G | 0.82 0.54 0.11 -1.50 -0.33 1.50 1.43 -0.33 0.15 0.75 0.51 1.44 1.43 -1.10 T | 0.34 0.54 -0.98 -3.47 -3.47 -2.77 -1.67 -0.03 -0.10 -3.47 -3.47 -3.47 -3.47 -0.10
LEU3_BFoat et. al.P = 1View matrix ↘
Fisher’s P-value1
Information content21.9
Max PWM score25.13
Recommended cutoff18.85
Position frequency matrix (PFM)
A | 0.01 0.02 0.01 0.01 0.97 0.13 0.10 0.18 0.08 0.23 0.24 0.09 0.07 0.30 0.01 0.74 0.07 0.12 0.20 0.34 0.01 0.01 0.88 0.25 0.20 C | 0.71 0.16 0.97 0.01 0.01 0.32 0.36 0.24 0.52 0.42 0.22 0.49 0.41 0.12 0.10 0.14 0.68 0.35 0.02 0.01 0.97 0.90 0.11 0.04 0.31 G | 0.16 0.62 0.01 0.01 0.01 0.53 0.19 0.22 0.38 0.34 0.40 0.35 0.52 0.06 0.57 0.01 0.02 0.26 0.46 0.25 0.01 0.08 0.01 0.02 0.48 T | 0.12 0.20 0.01 0.97 0.01 0.03 0.34 0.36 0.02 0.01 0.15 0.08 0.01 0.52 0.33 0.12 0.22 0.27 0.32 0.41 0.01 0.01 0.01 0.69 0.01
Position count matrix (PCM)
A | 1 2 1 1 97 13 10 18 8 23 24 9 7 30 1 74 7 12 20 34 1 1 88 25 20 C | 71 16 97 1 1 32 36 24 52 42 22 49 41 12 10 14 68 35 2 1 97 90 11 4 31 G | 16 62 1 1 1 53 19 22 38 34 40 35 52 6 56 1 2 26 46 25 1 8 1 2 48 T | 12 20 1 97 1 3 34 36 2 1 15 8 1 52 33 12 22 27 32 41 1 1 1 69 1
Position weight matrix (PWM)
A | -3.47 -2.77 -3.47 -3.47 1.11 -0.90 -1.16 -0.58 -1.39 -0.33 -0.29 -1.27 -1.52 -0.06 -3.47 0.84 -1.52 -0.98 -0.47 0.06 -3.47 -3.47 1.01 -0.25 -0.47 C | 1.37 -0.12 1.68 -2.89 -2.89 0.58 0.69 0.29 1.06 0.85 0.20 1.00 0.82 -0.41 -0.59 -0.25 1.33 0.66 -2.20 -2.89 1.68 1.61 -0.49 -1.50 0.54 G | -0.12 1.24 -2.89 -2.89 -2.89 1.08 0.05 0.20 0.75 0.64 0.80 0.66 1.06 -1.10 1.15 -2.89 -2.20 0.37 0.94 0.33 -2.89 -0.81 -2.89 -2.20 0.98 T | -0.98 -0.47 -3.47 1.11 -3.47 -2.37 0.06 0.12 -2.77 -3.47 -0.76 -1.39 -3.47 0.49 0.03 -0.98 -0.37 -0.17 0.00 0.25 -3.47 -3.47 -3.47 0.77 -3.47
LEU3Harbison et. al.P = 3.64e-21View matrix ↘
Fisher’s P-value3.64e-21
Information content13.49
Max PWM score13.78
Recommended cutoff9.82
Position frequency matrix (PFM)
A | 0.059 0.022 0.022 0.042 0.270 0.730 0.121 0.050 0.025 0.037 C | 0.772 0.921 0.021 0.043 0.056 0.062 0.761 0.896 0.053 0.044 G | 0.117 0.033 0.896 0.792 0.122 0.040 0.063 0.030 0.897 0.886 T | 0.052 0.024 0.062 0.123 0.552 0.167 0.055 0.024 0.025 0.032
Position count matrix (PCM)
A | 5 2 2 4 27 73 12 5 2 3 C | 77 92 2 4 5 6 76 89 5 4 G | 11 3 89 79 12 4 6 3 89 88 T | 5 2 6 12 55 16 5 2 2 3
Position weight matrix (PWM)
A | -1.69 -2.68 -2.68 -2.03 -0.17 0.82 -0.97 -1.86 -2.55 -2.16 C | 1.46 1.63 -2.15 -1.43 -1.17 -1.07 1.44 1.60 -1.22 -1.41 G | -0.43 -1.70 1.60 1.48 -0.39 -1.50 -1.05 -1.79 1.61 1.59 T | -1.82 -2.59 -1.64 -0.96 0.55 -0.65 -1.76 -2.59 -2.55 -2.30
LEU3Macisaac et. alP = 6.48e-18View matrix ↘
Fisher’s P-value6.48e-18
Information content16.09
Max PWM score14.32
Recommended cutoff9.97
Position frequency matrix (PFM)
A | 0.044 0.001 0.028 0.090 0.163 0.613 0.132 0.001 0.028 0.001 C | 0.927 0.911 0.001 0.001 0.001 0.223 0.839 0.970 0.044 0.137 G | 0.028 0.044 0.970 0.809 0.082 0.001 0.001 0.001 0.912 0.834 T | 0.001 0.044 0.001 0.100 0.754 0.163 0.028 0.028 0.016 0.028
Position count matrix (PCM)
A | 4 0 2 9 16 61 13 0 2 0 C | 92 91 0 0 0 22 83 97 4 13 G | 2 4 97 80 8 0 0 0 91 83 T | 0 4 0 10 75 16 2 2 1 2
Position weight matrix (PWM)
A | -1.98 -5.77 -2.44 -1.27 -0.67 0.65 -0.89 -5.77 -2.44 -5.77 C | 1.64 1.62 -5.19 -5.19 -5.19 0.21 1.54 1.68 -1.41 -0.27 G | -1.86 -1.41 1.68 1.50 -0.79 -5.19 -5.19 -5.19 1.62 1.53 T | -5.77 -1.98 -5.77 -1.16 0.86 -0.67 -2.44 -2.44 -3.00 -2.44
LEU3Morozov et. al.P = 1.66e-19View matrix ↘
Fisher’s P-value1.66e-19
Information content12.51
Max PWM score13.1
Recommended cutoff10.27
Position frequency matrix (PFM)
A | 0.032 0.092 0.031 0.044 0.071 0.241 0.106 0.089 0.037 0.026 C | 0.933 0.832 0.035 0.130 0.166 0.242 0.795 0.831 0.040 0.251 G | 0.012 0.053 0.891 0.607 0.039 0.091 0.034 0.044 0.910 0.684 T | 0.024 0.023 0.043 0.219 0.723 0.425 0.065 0.036 0.013 0.039
Position count matrix (PCM)
A | 3 9 3 4 7 24 10 8 3 2 C | 93 83 3 13 16 24 79 83 4 25 G | 1 5 89 60 3 9 3 4 91 68 T | 2 2 4 21 72 42 6 3 1 3
Position weight matrix (PWM)
A | -2.30 -1.25 -2.33 -1.98 -1.51 -0.28 -1.10 -1.28 -2.16 -2.51 C | 1.65 1.53 -1.64 -0.33 -0.08 0.30 1.49 1.53 -1.50 0.33 G | -2.71 -1.22 1.60 1.22 -1.53 -0.68 -1.67 -1.41 1.62 1.34 T | -2.59 -2.63 -2.01 -0.38 0.82 0.28 -1.59 -2.18 -3.20 -2.10
LEU3Pachkov et alP = 1.48e-18View matrix ↘
Fisher’s P-value1.48e-18
Information content18.37
Max PWM score14.58
Recommended cutoff11.01
Position frequency matrix (PFM)
A | 0.001 0.009 0.001 0.107 0.001 0.291 0.039 0.075 0.001 0.001 C | 0.994 0.991 0.001 0.001 0.001 0.337 0.961 0.925 0.002 0.338 G | 0.001 0.001 1.000 0.691 0.001 0.001 0.001 0.001 0.998 0.660 T | 0.006 0.001 0.001 0.202 1.000 0.372 0.001 0.001 0.001 0.002
Position count matrix (PCM)
A | 0 0 0 10 0 29 3 7 0 0 C | 99 99 0 0 0 33 96 92 0 33 G | 0 0 100 69 0 0 0 0 99 66 T | 0 0 0 20 100 37 0 0 0 0
Position weight matrix (PWM)
A | -5.77 -3.57 -5.77 -1.10 -5.77 -0.09 -2.10 -1.45 -5.77 -5.77 C | 1.71 1.71 -5.19 -5.19 -5.19 0.63 1.68 1.64 -4.50 0.63 G | -5.19 -5.19 1.71 1.35 -5.19 -5.19 -5.19 -5.19 1.71 1.30 T | -3.98 -5.77 -5.77 -0.46 1.14 0.15 -5.77 -5.77 -5.77 -5.08
LEU3Zhu et. al.P = 0.06748View matrix ↘
Fisher’s P-value0.06748
Information content12.63
Max PWM score14.04
Recommended cutoff9.42
Position frequency matrix (PFM)
A | 0.83 0.04 0.01 0.01 0.01 0.24 0.12 0.50 0.59 0.31 0.19 0.18 0.15 0.55 C | 0.01 0.93 0.97 0.01 0.05 0.65 0.05 0.06 0.09 0.20 0.17 0.54 0.09 0.14 G | 0.09 0.02 0.01 0.97 0.93 0.05 0.77 0.09 0.08 0.19 0.27 0.09 0.22 0.13 T | 0.07 0.02 0.01 0.01 0.01 0.06 0.06 0.35 0.23 0.30 0.37 0.18 0.53 0.18
Position count matrix (PCM)
A | 83 4 1 1 1 24 12 50 59 31 19 18 15 55 C | 1 93 97 1 5 65 5 6 9 20 17 54 9 14 G | 9 2 1 97 93 5 77 9 8 19 27 9 22 13 T | 7 2 1 1 1 6 6 35 23 30 37 18 53 18
Position weight matrix (PWM)
A | 0.95 -2.08 -3.47 -3.47 -3.47 -0.29 -0.98 0.45 0.61 -0.03 -0.52 -0.58 -0.76 0.54 C | -2.89 1.64 1.68 -2.89 -1.28 1.28 -1.28 -1.10 -0.69 0.11 -0.06 1.10 -0.69 -0.25 G | -0.69 -2.20 -2.89 1.68 1.64 -1.28 1.45 -0.69 -0.81 0.05 0.41 -0.69 0.20 -0.33 T | -1.52 -2.77 -3.47 -3.47 -3.47 -1.67 -1.67 0.09 -0.33 -0.06 0.15 -0.58 0.50 -0.58
LEU3Zhao and StormoP = 9.71e-05View matrix ↘
Fisher’s P-value9.71e-05
Information content6.548
Max PWM score7.58
Recommended cutoff5.89
Position frequency matrix (PFM)
A | 0.483 0.189 0.091 0.001 0.042 0.298 0.305 0.319 C | 0.116 0.498 0.871 0.025 0.091 0.336 0.205 0.177 G | 0.151 0.151 0.037 0.973 0.866 0.230 0.324 0.151 T | 0.250 0.162 0.001 0.001 0.001 0.135 0.166 0.353
Position count matrix (PCM)
A | 48 18 9 0 4 29 30 31 C | 11 49 87 2 9 33 20 17 G | 15 15 3 97 86 23 32 15 T | 25 16 0 0 0 13 16 35
Position weight matrix (PWM)
A | 0.41 -0.53 -1.26 -5.77 -2.03 -0.07 -0.05 -0.00 C | -0.44 1.02 1.58 -1.97 -0.68 0.62 0.13 -0.02 G | -0.18 -0.18 -1.58 1.69 1.57 0.25 0.59 -0.18 T | -0.25 -0.68 -5.77 -5.77 -5.77 -0.86 -0.66 0.10
03 / EXPERIMENTAL CONTEXT
Gene-level annotations and interactions.
Genes bound in ChIP-chip experiments 70 genes
YAL028W, YAL029C, YAR009C, YBR048W, YBR068C, YCR018C-A, YCR019W, YCR024C-A, YDR042C, YDR064W, YDR131C, YDR210W-D, YDR278C, YEL050C, YEL055C, YER007C-A, YER071C, YER072W, YER073W, YER137C, YER189W, YER190W, YGL001C, YGL009C, YGL135W, YGL136C, YGR190C, YGR191W, YGR221C, YGR255C, YGR256W, YHL034C, YHR207C, YHR208W, YIL014W, YIL015C-A, YJL139C, YJL148W, YJL191W, YJL192C, YJR016C, YJR018W, YJR100C, YKL118W, YKL120W, YKL172W, YLR105C, YLR354C, YLR355C, YLR356W, YLR367W, YLR368W, YML124C, YMR014W, YMR108W, YMR193W, YMR194W, YNL102W, YNL103W, YNL104C, YNL337W, YNR050C, YOL121C, YOR108W, YOR226C, YOR227W, YOR236W, YOR271C, YOR369C, YPL198W
Genes affected by TF deletion 63 genes
YJR016C, YJR048W, YOR225W, YGL009C, YNL241C, YOR226C, YHR145C, YPL016W, YBR068C, YLR307W, YOL104C, YGL071W, YHR208W, YIL050W, YOR161C, YPL084W, YBR097W, YBR129C, YOR316C, YCR050C, YMR173W, YER152C, YIL121W, YLR099C, YHR063C, YLR348C, YPR026W, YMR291W, YFL021W, YLR349W, YMR108W, YMR110C, YJR003C, YOL058W, YGR164W, YLR451W, YKL120W, YMR173W-A, YOR084W, YKL030W, YBR083W, YKL029C, YLR355C, YER091C, YHR018C, YAL062W, YGR146C, YGR117C, YHR136C, YDR061W, YFL008W, YGL190C, YGL255W, YKR036C, YNL104C, YDR245W, YHR135C, YOR375C, YBL051C, YMR276W, YOL101C, YER073W, YNL324W
Genes supported by both experiments 10 genes
YBR068C, YER073W, YGL009C, YHR208W, YJR016C, YKL120W, YLR355C, YMR108W, YNL104C, YOR226C
Predicted TF–TF partners 1 genes
GCN4