IXR1

YKL032C, ORD1

Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b

01 / RECOMMENDED MATRIX

Best-performing DNA-binding model.

RecommendedSource: Macisaac et. al

Fisher’s P-value3.59e-09

Information content20.18

Max PWM score18.34

Recommended cutoff13.5

View and copy the recommended matrices ↘

Position frequency matrix (PFM)

A | 0.997 0.753 0.433 0.189 0.378 0.377 0.189 0.754 0.754 0.001 0.001 0.189 0.056 0.001 0.001 
C | 0.001 0.001 0.001 0.755 0.620 0.001 0.001 0.001 0.001 0.001 0.997 0.001 0.001 0.001 0.001 
G | 0.001 0.001 0.377 0.001 0.001 0.621 0.566 0.244 0.001 0.997 0.001 0.809 0.942 0.377 0.809 
T | 0.001 0.245 0.189 0.055 0.001 0.001 0.244 0.001 0.244 0.001 0.001 0.001 0.001 0.621 0.189

Position count matrix (PCM)

A |  99  75  43  18  37  37  18  75  75   0   0  18   5   0   0 
C |   0   0   0  75  62   0   0   0   0   0  99   0   0   0   0 
G |   0   0  37   0   0  62  56  24   0  99   0  80  94  37  80 
T |   0  24  18   5   0   0  24   0  24   0   0   0   0  62  18

Position weight matrix (PWM)

A |  1.14  0.86  0.30 -0.53  0.17  0.16 -0.53  0.86  0.86 -5.77 -5.77 -0.53 -1.74 -5.77 -5.77 
C | -5.19 -5.19 -5.19  1.43  1.24 -5.19 -5.19 -5.19 -5.19 -5.19  1.71 -5.19 -5.19 -5.19 -5.19 
G | -5.19 -5.19  0.74 -5.19 -5.19  1.24  1.15  0.30 -5.19  1.71 -5.19  1.50  1.66  0.74  1.50 
T | -5.77 -0.27 -0.53 -1.76 -5.77 -5.77 -0.27 -5.77 -0.27 -5.77 -5.77 -5.77 -5.77  0.66 -0.53

02 / COMPARATIVE BENCHMARKS

Alternative candidate matrices 1

Historical matrix candidates from the original ScerTF database. Expand a source to inspect its original logo, scores, and matrix values.

IXR1Foat et. al.P = 6.12e-06View matrix ↘

Fisher’s P-value6.12e-06

Information content17.96

Max PWM score19.09

Recommended cutoff9.65

Position frequency matrix (PFM)

A | 0.01 0.01 0.93 0.01 0.02 0.07 0.20 0.13 0.12 0.61 0.01 0.01 0.01 0.08 0.76 0.57 0.01 
C | 0.64 0.23 0.01 0.97 0.01 0.22 0.30 0.03 0.03 0.11 0.42 0.01 0.76 0.01 0.02 0.01 0.01 
G | 0.14 0.43 0.05 0.01 0.96 0.70 0.50 0.39 0.67 0.17 0.25 0.13 0.12 0.01 0.08 0.19 0.97 
T | 0.21 0.34 0.01 0.01 0.01 0.01 0.01 0.46 0.18 0.10 0.31 0.85 0.12 0.90 0.13 0.24 0.01

Position count matrix (PCM)

A |   1   1  93   1   2   7  20  13  12  61   1   1   1   8  76  56   1 
C |  64  23   1  97   1  22  30   3   3  11  42   1  76   1   2   1   1 
G |  14  43   5   1  96  70  50  39  67  17  25  13  12   1   8  19  97 
T |  21  34   1   1   1   1   1  46  18  10  31  85  12  90  13  24   1

Position weight matrix (PWM)

A | -3.47 -3.47  1.07 -3.47 -2.77 -1.52 -0.47 -0.90 -0.98  0.65 -3.47 -3.47 -3.47 -1.39  0.86  0.58 -3.47 
C |  1.27  0.25 -2.89  1.68 -2.89  0.20  0.51 -1.79 -1.79 -0.49  0.85 -2.89  1.44 -2.89 -2.20 -2.89 -2.89 
G | -0.25  0.87 -1.28 -2.89  1.67  1.36  1.02  0.77  1.31 -0.06  0.33 -0.33 -0.41 -2.89 -0.81  0.05  1.68 
T | -0.42  0.06 -3.47 -3.47 -3.47 -3.47 -3.47  0.36 -0.58 -1.16 -0.03  0.98 -0.98  1.03 -0.90 -0.29 -3.47

Foat et. al.

03 / EXPERIMENTAL CONTEXT

Gene-level annotations and interactions.

Genes bound in ChIP-chip experiments 86 genes

YAL040C, YAL064W, YBL018C, YBL029W, YBL087C, YBR007C, YBR008C, YBR152W, YBR163W, YDL247W, YDR042C, YDR084C, YDR086C, YDR098C, YDR101C, YDR259C, YDR314C, YDR426C, YDR427W, YDR441C, YDR442W, YDR472W, YEL004W, YEL005C, YER011W, YER133W, YER158C, YFL029C, YGL116W, YGL190C, YGR024C, YGR114C, YGR115C, YGR249W, YGR279C, YHR005C, YHR005C-A, YHR028C, YHR092C, YHR093W, YHR096C, YHR146W, YIL015C-A, YIL119C, YIR020C, YJL023C, YJL216C, YJR100C, YJR160C, YKL044W, YKL077W, YKL167C, YKR010C, YKR075C, YLL033W, YLL034C, YLL041C, YLR002C, YLR112W, YLR143W, YLR165C, YLR166C, YLR167W, YLR286C, YLR287C, YLR300W, YMR052W, YMR177W, YMR260C, YMR272C, YMR279C, YNL120C, YNL145W, YNL146W, YNR054C, YOL099C, YOR023C, YOR024W, YOR025W, YOR049C, YOR050C, YOR253W, YOR287C, YOR315W, YOR339C, YPL156C

Genes affected by TF deletion 323 genes

YDR034C-C, YDR366C, YER178W, YGL173C, YHL016C, YHL048W, YKR041W, YKR012C, YMR045C, YMR046W-A, YOL013W-A, YOR192C-A, YOR227W, YMR016C, YAL007C, YDR222W, YEL017W, YGL009C, YGR095C, YLR463C, YLR465C, YLR467W, YOR039W, YOR071C, YPL015C, YPL047W, YDR034C-A, YDR034C-D, YDR365W-B, YGR279C, YIL141W, YJR015W, YKR011C, YKR013W, YKR076W, YLR213C, YLR243W, YMR011W, YMR042W, YMR046C, YOR192C, YOR192C-B, YPL177C, YMR266W, YAL003W, YFR035C, YGR122C-A, YHR145C, YLR462W, YLR464W, YMR194C-A, YPL016W, YPR138C, YBR066C, YDL037C, YJR147W, YLL066C, YLR342W, YMR135W-A, YNL113W, YNL115C, YOL104C, YOL106W, YOR317W, YOR347C, YGR244C, YHR210C, YLR152C, YLR157C-A, YNL333W, YNL337W, YBR129C, YDR098C-A, YFL013C, YFR006W, YKR102W, YLR341W, YMR135C, YMR136W, YNL142W, YOL103W-B, YOL105C, YOL139C, YOL109W, YOR344C, YPR013C, YPR015C, YOR086C, YCL020W, YDR340W, YDR281C, YER029C, YHR211W, YKL206C, YMR315W, YNL332W, YNL338W, YBR012C, YBR012W-B, YDR380W, YHR005C, YJR026W, YJR028W, YLR256W, YLR227W-A, YMR050C, YOR233W, YAR010C, YBR169C, YEL024W, YEL056W, YGR161C-C, YGR161W-A, YGR105W, YLR410W-B, YNL219C, YNL284C-A, YOR009W, YOR075W, YPL057C, YBR012W-A, YCR018C-A, YHL049C, YIL121W, YIL155C, YJR027W, YJR029W, YLR256W-A, YMR051C, YMR023C, YNL054W-A, YNR066C, YOR264W, YPL216W, YAR009C, YBR230C, YGR161C-D, YGR104C, YGR161W-B, YLR035C-A, YLR067C, YML003W, YLR410W-A, YPL026C, YBR132C, YJR151C, YLR348C, YPL274W, YCL026C-A, YBR265W, YHR214C-B, YHR215W, YHR217C, YIL060W, YJL217W, YPL154C, YPL092W, YPL156C, YFL014W, YDL038C, YDR170W-A, YFL021W, YGR036C, YGR038C-A, YHR094C, YJR156C, YLL067C, YLR312C, YLR343W, YLR345W, YLR349W, YPL137C, YAR071W, YBL030C, YCL025C, YBR296C, YDR316W-A, YGR189C, YHR213W, YHR214C-C, YHR214W-A, YNR001C, YPR167C, YGR262C, YIL064W, YJR003C, YCR061W, YGL250W, YHL026C, YIL162W, YLR232W, YML133C, YNL097C, YNL101W, YNR077C, YOL002C, YPL257W-A, YDR345C, YER101C, YIL114C, YMR143W, YBR241C, YDR261W-A, YDR210W, YJL101C, YKL062W, YPL066W, YBL101W-A, YER159C-A, YER190W, YLR231C, YLR233C, YML128C, YMR056C, YNL037C, YDR209C, YFR047C, YGR108W, YKL093W, YPL004C, YDL021W, YFL026W, YGR049W, YJL038C, YKL032C, YLL050C, YLR356W, YMR122C, YOL152W, YOL126C, YCL038C, YGR234W, YKL153W, YML045W-A, YBR139W, YDL014W, YDR481C, YDR544C, YFL027C, YGR044C, YMR086W, YMR148W, YMR088C, YMR090W, YNL160W, YOL155C, YOL157C, YPR002C-A, YPR035W, YNL316C, YBL005W-A, YBL042C, YJL196C, YML040W, YMR297W, YNR040W, YOR142W-B, YOR144C, YOR148C, YOR180C, YPR179C, YER138C, YIL140W, YJR110W, YLR299W, YMR006C, YMR039C, YAL062W, YAR053W, YBR217W, YDR210W-D, YHR170W, YJL077C, YPL041C, YBL107W-A, YFL002W-B, YER137C-A, YER138W-A, YGL255W, YIL169C, YLR237W, YLR300W, YMR034C, YNL104C, YOL003C, YPL257W-B, YBR244W, YDR210W-A, YDR239C, YDR210W-C, YDR241W, YHR137W, YJL076W, YMR211W, YPR158W-B, YFR030W, YGR051C, YLR334C, YMR158C-B, YMR158W-A, YNL141W, YOL103W-A, YOR343C-B, YPR012W, YCL040W, YDR365W-A, YIL011W, YPL136W, YFL064C, YGR027W-A, YJL042W, YOL101C, YOR306C, YOR343C-A, YOR374W, YPR069C, YPR009W, YGL096W, YGL160W, YGR203W, YGR235C, YNL324W, YPL103C

Genes supported by both experiments 4 genes

YGR279C, YHR005C, YLR300W, YPL156C