← All factors / TF RECORD

IME1

YJR094C

View at SGD ↗

Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p

01 / RECOMMENDED MATRIX

Best-performing DNA-binding model.

RecommendedSource: Macisaac et. al
Fisher’s P-value4.34e-05
Information content15.87
Max PWM score12.27
Recommended cutoff11.38
View and copy the recommended matrices ↘
Position frequency matrix (PFM)
A | 0.001 0.018 0.001 0.001 0.001 0.001 0.997 0.118 
C | 0.997 0.770 0.001 0.997 0.631 0.001 0.001 0.001 
G | 0.001 0.211 0.997 0.001 0.257 0.997 0.001 0.880 
T | 0.001 0.001 0.001 0.001 0.111 0.001 0.001 0.001 
Position count matrix (PCM)
A |   0   1   0   0   0   0  99  11 
C |  99  77   0  99  63   0   0   0 
G |   0  21  99   0  25  99   0  88 
T |   0   0   0   0  11   0   0   0 
Position weight matrix (PWM)
A | -5.77 -2.88 -5.77 -5.77 -5.77 -5.77  1.14 -1.00 
C |  1.71  1.45 -5.19  1.71  1.25 -5.19 -5.19 -5.19 
G | -5.19  0.16  1.71 -5.19  0.36  1.71 -5.19  1.59 
T | -5.77 -5.77 -5.77 -5.77 -1.06 -5.77 -5.77 -5.77 
02 / COMPARATIVE BENCHMARKS

Alternative candidate matrices 2

Historical matrix candidates from the original ScerTF database. Expand a source to inspect its original logo, scores, and matrix values.

IME1_AFoat et. al.P = 0.0166View matrix ↘
Sequence logo for IME1_A
Fisher’s P-value0.0166
Information content16.28
Max PWM score14.84
Recommended cutoff10.75
Position frequency matrix (PFM)
A | 0.47 0.19 0.01 0.01 0.03 0.97 0.05 0.01 0.01 0.01 0.48 0.22 0.55 
C | 0.20 0.02 0.01 0.97 0.01 0.01 0.62 0.02 0.01 0.04 0.25 0.01 0.41 
G | 0.33 0.78 0.40 0.01 0.05 0.01 0.01 0.20 0.95 0.94 0.27 0.77 0.03 
T | 0.01 0.01 0.59 0.01 0.92 0.01 0.32 0.77 0.03 0.01 0.01 0.01 0.01 
Position count matrix (PCM)
A |  47  19   1   1   3  97   5   1   1   1  48  22  55 
C |  20   2   1  97   1   1  62   2   1   4  25   1  41 
G |  33  78  40   1   5   1   1  20  95  94  27  77   3 
T |   1   1  59   1  92   1  32  77   3   1   1   1   1 
Position weight matrix (PWM)
A |  0.38 -0.52 -3.47 -3.47 -2.37  1.11 -1.86 -3.47 -3.47 -3.47  0.41 -0.37  0.54 
C |  0.11 -2.20 -2.89  1.68 -2.89 -2.89  1.24 -2.20 -2.89 -1.50  0.33 -2.89  0.82 
G |  0.61  1.47  0.80 -2.89 -1.28 -2.89 -2.89  0.11  1.66  1.65  0.41  1.45 -1.79 
T | -3.47 -3.47  0.61 -3.47  1.06 -3.47  0.00  0.88 -2.37 -3.47 -3.47 -3.47 -3.47 
IME1_BFoat et. al.P = 1View matrix ↘
Sequence logo for IME1_B
Fisher’s P-value1
Information content15.82
Max PWM score14.9
Recommended cutoff11.18
Position frequency matrix (PFM)
A | 0.01 0.88 0.01 0.03 0.01 0.79 0.45 0.89 0.01 0.52 0.01 0.07 
C | 0.09 0.01 0.13 0.83 0.97 0.01 0.54 0.01 0.97 0.47 0.53 0.05 
G | 0.01 0.10 0.69 0.08 0.01 0.18 0.01 0.10 0.01 0.01 0.01 0.87 
T | 0.89 0.01 0.17 0.06 0.01 0.02 0.01 0.01 0.01 0.01 0.45 0.01 
Position count matrix (PCM)
A |   1  88   1   3   1  79  45  89   1  52   1   7 
C |   9   1  13  83  97   1  54   1  97  47  53   5 
G |   1  10  69   8   1  18   1  10   1   1   1  87 
T |  89   1  17   6   1   2   1   1   1   1  45   1 
Position weight matrix (PWM)
A | -3.47  1.01 -3.47 -2.37 -3.47  0.90  0.34  1.02 -3.47  0.49 -3.47 -1.52 
C | -0.69 -2.89 -0.33  1.53  1.68 -2.89  1.10 -2.89  1.68  0.96  1.08 -1.28 
G | -2.89 -0.59  1.34 -0.81 -2.89  0.00 -2.89 -0.59 -2.89 -2.89 -2.89  1.58 
T |  1.02 -3.47 -0.63 -1.67 -3.47 -2.77 -3.47 -3.47 -3.47 -3.47  0.34 -3.47 
03 / EXPERIMENTAL CONTEXT

Gene-level annotations and interactions.

Genes bound in ChIP-chip experiments 5 genes

YBR253W, YDR206W, YGR095C, YGR096W, YGR125W

Genes affected by TF deletion 30 genes

YDR034C-D, YPL016W, YBR128C, YLL034C, YPL283C, YLR156W, YNL339C, YMR100W, YDR076W, YOR043W, YJR094C, YJR148W, YNL278W, YOL114C, YOR329C, YIL022W, YLR160C, YPL092W, YCR024C-A, YDR022C, YKR026C, YKR093W, YML013C-A, YOL119C, YPR164W, YLR297W, YLR117C, YOR343C-B, YOR034C, YFL068W

Predicted TF–TF partners 5 genes

DAL82, RSC3, RSC30, SUT1, YPR196W

Explore 5 original interaction plots →