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HAP5

YOR358W

View at SGD ↗

Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex

01 / RECOMMENDED MATRIX

Best-performing DNA-binding model.

RecommendedSource: Pachkov et al
Fisher’s P-value4.17e-10
Information content14.31
Max PWM score14.68
Recommended cutoff8.42
View and copy the recommended matrices ↘
Position frequency matrix (PFM)
A | 0.146 0.046 0.025 0.181 0.386 0.029 0.021 0.001 0.118 1.000 0.001 0.001 0.093 0.085 0.001 
C | 0.213 0.443 0.333 0.249 0.308 0.144 0.696 0.159 0.288 0.001 0.001 0.001 0.001 0.117 0.381 
G | 0.235 0.488 0.547 0.471 0.093 0.288 0.147 0.001 0.419 0.001 0.001 0.056 0.907 0.736 0.001 
T | 0.407 0.022 0.095 0.099 0.213 0.540 0.136 0.841 0.175 0.001 1.000 0.944 0.001 0.062 0.619 
Position count matrix (PCM)
A |  14   4   2  18  38   2   2   0  11 100   0   0   9   8   0 
C |  21  44  33  24  30  14  69  15  28   0   0   0   0  11  38 
G |  23  48  54  47   9  28  14   0  41   0   0   5  90  73   0 
T |  40   2   9   9  21  54  13  84  17   0 100  94   0   6  61 
Position weight matrix (PWM)
A | -0.78 -1.94 -2.55 -0.57  0.19 -2.40 -2.72 -5.77 -1.00  1.14 -5.77 -5.77 -1.24 -1.33 -5.77 
C |  0.17  0.90  0.62  0.32  0.54 -0.22  1.35 -0.12  0.47 -5.19 -5.19 -5.19 -5.19 -0.43  0.75 
G |  0.27  1.00  1.11  0.96 -0.66  0.47 -0.20 -5.19  0.84 -5.19 -5.19 -1.17  1.62  1.41 -5.19 
T |  0.24 -2.68 -1.21 -1.17 -0.41  0.52 -0.86  0.97 -0.60 -5.77  1.14  1.08 -5.77 -1.64  0.66 
02 / COMPARATIVE BENCHMARKS

Alternative candidate matrices 4

Historical matrix candidates from the original ScerTF database. Expand a source to inspect its original logo, scores, and matrix values.

HAP5_AFoat et. al.P = 0.007186View matrix ↘
Sequence logo for HAP5_A
Fisher’s P-value0.007186
Information content10.17
Max PWM score10.58
Recommended cutoff5.98
Position frequency matrix (PFM)
A | 0.17 0.21 0.01 0.53 0.97 0.97 0.97 0.38 0.56 0.29 0.37 
C | 0.46 0.51 0.01 0.01 0.01 0.01 0.01 0.46 0.19 0.25 0.41 
G | 0.36 0.20 0.97 0.46 0.01 0.01 0.01 0.14 0.25 0.20 0.03 
T | 0.01 0.08 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.26 0.19 
Position count matrix (PCM)
A |  17  21   1  53  97  97  97  38  56  28  37 
C |  46  51   1   1   1   1   1  46  19  25  41 
G |  36  20  97  46   1   1   1  14  25  20   3 
T |   1   8   1   1   1   1   1   2   1  26  19 
Position weight matrix (PWM)
A | -0.63 -0.42 -3.47  0.50  1.11  1.11  1.11  0.17  0.56 -0.10  0.15 
C |  0.94  1.04 -2.89 -2.89 -2.89 -2.89 -2.89  0.94  0.05  0.33  0.82 
G |  0.69  0.11  1.68  0.94 -2.89 -2.89 -2.89 -0.25  0.33  0.11 -1.79 
T | -3.47 -1.39 -3.47 -3.47 -3.47 -3.47 -3.47 -2.77 -3.47 -0.21 -0.52 
HAP5_BFoat et. al.P = 0.02613View matrix ↘
Sequence logo for HAP5_B
Fisher’s P-value0.02613
Information content14.85
Max PWM score13.75
Recommended cutoff12.04
Position frequency matrix (PFM)
A | 0.01 0.73 0.68 0.87 0.01 0.01 0.82 0.03 0.02 0.78 0.86 0.01 0.25 
C | 0.01 0.01 0.01 0.12 0.08 0.87 0.16 0.01 0.94 0.01 0.01 0.18 0.01 
G | 0.03 0.01 0.30 0.01 0.90 0.12 0.01 0.02 0.01 0.07 0.05 0.01 0.26 
T | 0.95 0.26 0.01 0.01 0.01 0.01 0.01 0.94 0.04 0.14 0.08 0.80 0.49 
Position count matrix (PCM)
A |   1  73  68  87   1   1  82   3   2  78  86   1  25 
C |   1   1   1  12   8  87  16   1  94   1   1  18   1 
G |   3   1  30   1  90  12   1   2   1   7   5   1  26 
T |  95  26   1   1   1   1   1  94   4  14   8  80  49 
Position weight matrix (PWM)
A | -3.47  0.82  0.75  1.00 -3.47 -3.47  0.94 -2.37 -2.77  0.89  0.99 -3.47 -0.25 
C | -2.89 -2.89 -2.89 -0.41 -0.81  1.58 -0.12 -2.89  1.65 -2.89 -2.89  0.00 -2.89 
G | -1.79 -2.89  0.51 -2.89  1.61 -0.41 -2.89 -2.20 -2.89 -0.94 -1.28 -2.89  0.37 
T |  1.09 -0.21 -3.47 -3.47 -3.47 -3.47 -3.47  1.08 -2.08 -0.83 -1.39  0.92  0.43 
HAP5Harbison et. al.P = 0.4836View matrix ↘
Sequence logo for HAP5
Fisher’s P-value0.4836
Information content8.513
Max PWM score6.66
Recommended cutoff6.66
Position frequency matrix (PFM)
A | 0.012 0.012 0.965 0.965 0.012 
C | 0.965 0.965 0.012 0.012 0.012 
G | 0.012 0.012 0.012 0.012 0.012 
T | 0.012 0.012 0.012 0.012 0.965 
Position count matrix (PCM)
A |   1   1  96  96   1 
C |  96  96   1   1   1 
G |   1   1   1   1   1 
T |   1   1   1   1  96 
Position weight matrix (PWM)
A | -3.28 -3.28  1.10  1.10 -3.28 
C |  1.68  1.68 -2.71 -2.71 -2.71 
G | -2.71 -2.71 -2.71 -2.71 -2.71 
T | -3.28 -3.28 -3.28 -3.28  1.10 
HAP5Macisaac et. alP = 0.4836View matrix ↘
Sequence logo for HAP5
Fisher’s P-value0.4836
Information content8.496
Max PWM score6.66
Recommended cutoff6.66
Position frequency matrix (PFM)
A | 0.012 0.012 0.964 0.964 0.012 
C | 0.964 0.964 0.012 0.012 0.012 
G | 0.012 0.012 0.012 0.012 0.012 
T | 0.012 0.012 0.012 0.012 0.964 
Position count matrix (PCM)
A |   1   1  96  96   1 
C |  96  96   1   1   1 
G |   1   1   1   1   1 
T |   1   1   1   1  96 
Position weight matrix (PWM)
A | -3.28 -3.28  1.10  1.10 -3.28 
C |  1.68  1.68 -2.71 -2.71 -2.71 
G | -2.71 -2.71 -2.71 -2.71 -2.71 
T | -3.28 -3.28 -3.28 -3.28  1.10 
03 / EXPERIMENTAL CONTEXT

Gene-level annotations and interactions.

Genes bound in ChIP-chip experiments 47 genes

YBL074C, YBR012W-A, YBR012W-B, YBR099C, YBR128C, YBR167C, YBR168W, YCR018C-A, YCR019W, YCR054C, YCR076C, YDL013W, YDL152W, YDL170W, YDL171C, YDR048C, YDR142C, YDR210W-D, YDR245W, YDR495C, YDR503C, YDR522C, YEL050C, YER049W, YER174C, YGL001C, YGL132W, YGL187C, YGR024C, YGR263C, YGR265W, YHR011W, YHR051W, YJL003W, YJL004C, YLL027W, YLR105C, YLR168C, YLR169W, YLR171W, YLR220W, YLR435W, YMR194W, YNR050C, YOL091W, YOR005C, YPL207W

Genes affected by TF deletion 94 genes

YCR040W, YGL234W, YNL016W, YOR225W, YGL009C, YLR058C, YBR031W, YMR044W, YOR226C, YGR155W, YOR066W, YOR382W, YDR096W, YHR025W, YOR285W, YOR351C, YPL187W, YER026C, YGR180C, YHR208W, YML023C, YML058W-A, YNL335W, YBR067C, YCR077C, YDR461W, YNL146W, YPR015C, YCL018W, YBR256C, YIL015W, YNL332W, YPL145C, YDR012W, YIL154C, YLR286C, YAL013W, YDL070W, YGR099W, YJR094C, YAL012W, YLR034C, YLR438W, YMR171C, YNL220W, YBR070C, YJL026W, YLR348C, YDR320C, YJL153C, YKL178C, YLR343W, YLR349W, YBL032W, YCL027W, YKL177W, YKL148C, YMR323W, YMR057C, YOL058W, YLR040C, YOR393W, YCL066W, YKL120W, YLR041W, YPL032C, YFL026W, YMR120C, YOR305W, YOR383C, YGL089C, YGR234W, YLR136C, YNL190W, YPL281C, YPR035W, YER040W, YJR004C, YNR044W, YHL004W, YHR018C, YLR299W, YLR303W, YMR006C, YMR186W, YBR053C, YLR302C, YDL121C, YGL032C, YKL069W, YKL164C, YLR180W, YNR055C, YLR359W

Predicted TF–TF partners 2 genes

SKN7, SUT1

Explore 2 original interaction plots →