← All factors / TF RECORD

HAP4

YKL109W

View at SGD ↗

Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex

01 / RECOMMENDED MATRIX

Best-performing DNA-binding model.

RecommendedSource: Harbison et. al.
Fisher’s P-value1.98e-21
Information content7.999
Max PWM score9.73
Recommended cutoff8.11
View and copy the recommended matrices ↘
Position frequency matrix (PFM)
A | 0.279 0.358 0.055 0.040 0.910 0.896 0.077 0.130 0.906 
C | 0.103 0.247 0.853 0.687 0.024 0.033 0.064 0.606 0.025 
G | 0.532 0.309 0.041 0.175 0.038 0.023 0.071 0.166 0.040 
T | 0.086 0.085 0.052 0.098 0.029 0.048 0.787 0.099 0.030 
Position count matrix (PCM)
A |  27  35   5   4  91  89   7  13  90 
C |  10  24  85  68   2   3   6  60   2 
G |  53  30   4  17   3   2   7  16   4 
T |   8   8   5   9   2   4  78   9   3 
Position weight matrix (PWM)
A | -0.14  0.11 -1.76 -2.08  1.05  1.03 -1.42 -0.90  1.04 
C | -0.56  0.32  1.56  1.34 -2.01 -1.70 -1.03  1.21 -1.97 
G |  1.08  0.54 -1.48 -0.03 -1.56 -2.06 -0.93 -0.08 -1.50 
T | -1.31 -1.33 -1.82 -1.18 -2.40 -1.90  0.90 -1.17 -2.37 
02 / COMPARATIVE BENCHMARKS

Alternative candidate matrices 5

Historical matrix candidates from the original ScerTF database. Expand a source to inspect its original logo, scores, and matrix values.

HAP4_AFoat et. al.P = 0.4463View matrix ↘
Sequence logo for HAP4_A
Fisher’s P-value0.4463
Information content16.01
Max PWM score15.45
Recommended cutoff10.68
Position frequency matrix (PFM)
A | 0.03 0.02 0.49 0.95 0.42 0.01 0.22 0.01 0.38 0.89 0.01 0.01 0.37 0.84 0.05 
C | 0.03 0.32 0.04 0.01 0.51 0.03 0.01 0.50 0.42 0.09 0.97 0.97 0.05 0.04 0.01 
G | 0.11 0.02 0.35 0.01 0.05 0.95 0.01 0.01 0.10 0.02 0.01 0.01 0.19 0.01 0.01 
T | 0.83 0.64 0.12 0.03 0.02 0.01 0.76 0.49 0.11 0.01 0.01 0.01 0.39 0.11 0.94 
Position count matrix (PCM)
A |   3   2  49  95  42   1  22   1  38  89   1   1  37  84   5 
C |   3  32   4   1  51   3   1  50  42   9  97  97   5   4   1 
G |  11   2  35   1   5  95   1   1  10   2   1   1  19   1   1 
T |  83  64  12   3   2   1  76  49  11   1   1   1  39  11  94 
Position weight matrix (PWM)
A | -2.37 -2.77  0.43  1.09  0.27 -3.47 -0.37 -3.47  0.17  1.02 -3.47 -3.47  0.15  0.97 -1.86 
C | -1.79  0.58 -1.50 -2.89  1.04 -1.79 -2.89  1.02  0.85 -0.69  1.68  1.68 -1.28 -1.50 -2.89 
G | -0.49 -2.20  0.66 -2.89 -1.28  1.66 -2.89 -2.89 -0.59 -2.20 -2.89 -2.89  0.05 -2.89 -2.89 
T |  0.95  0.69 -0.98 -2.37 -2.77 -3.47  0.86  0.43 -1.07 -3.47 -3.47 -3.47  0.20 -1.07  1.08 
HAP4_BFoat et. al.P = 0.01641View matrix ↘
Sequence logo for HAP4_B
Fisher’s P-value0.01641
Information content10.3
Max PWM score11.93
Recommended cutoff6.12
Position frequency matrix (PFM)
A | 0.01 0.09 0.22 0.01 0.38 0.97 0.01 0.04 0.75 0.01 0.36 0.14 
C | 0.30 0.44 0.38 0.91 0.26 0.01 0.04 0.01 0.22 0.54 0.40 0.26 
G | 0.36 0.17 0.23 0.01 0.01 0.01 0.94 0.10 0.02 0.10 0.06 0.55 
T | 0.34 0.29 0.17 0.08 0.36 0.01 0.01 0.85 0.01 0.34 0.18 0.05 
Position count matrix (PCM)
A |   1   9  22   1  38  97   1   4  75   1  36  14 
C |  30  44  38  91  26   1   4   1  22  54  40  26 
G |  36  17  23   1   1   1  94  10   2  10   6  55 
T |  34  28  17   8  36   1   1  85   1  34  18   5 
Position weight matrix (PWM)
A | -3.47 -1.27 -0.37 -3.47  0.17  1.11 -3.47 -2.08  0.85 -3.47  0.12 -0.83 
C |  0.51  0.89  0.75  1.62  0.37 -2.89 -1.50 -2.89  0.20  1.10  0.80  0.37 
G |  0.69 -0.06  0.25 -2.89 -2.89 -2.89  1.65 -0.59 -2.20 -0.59 -1.10  1.12 
T |  0.06 -0.10 -0.63 -1.39  0.12 -3.47 -3.47  0.98 -3.47  0.06 -0.58 -1.86 
HAP4_CFoat et. al.P = 1View matrix ↘
Sequence logo for HAP4_C
Fisher’s P-value1
Information content22.55
Max PWM score24.68
Recommended cutoff18.51
Position frequency matrix (PFM)
A | 0.01 0.18 0.38 0.86 0.01 0.01 0.50 0.33 0.35 0.24 0.01 0.73 0.16 0.08 0.22 0.01 0.36 0.58 0.08 0.11 0.43 0.01 0.01 0.03 0.03 0.01 
C | 0.11 0.01 0.07 0.03 0.01 0.01 0.35 0.01 0.26 0.29 0.69 0.09 0.31 0.33 0.21 0.91 0.13 0.01 0.36 0.01 0.03 0.01 0.02 0.01 0.08 0.01 
G | 0.87 0.25 0.41 0.10 0.97 0.01 0.01 0.23 0.18 0.19 0.12 0.16 0.12 0.57 0.39 0.01 0.05 0.20 0.45 0.58 0.01 0.97 0.96 0.15 0.01 0.52 
T | 0.01 0.56 0.14 0.01 0.01 0.97 0.14 0.43 0.21 0.27 0.18 0.03 0.41 0.01 0.18 0.07 0.45 0.22 0.11 0.30 0.54 0.01 0.01 0.81 0.88 0.47 
Position count matrix (PCM)
A |   1  18  38  86   1   1  50  33  35  24   1  73  16   8  22   1  36  57   8  11  43   1   1   3   3   1 
C |  11   1   7   3   1   1  35   1  26  28  69   9  31  33  21  91  13   1  36   1   3   1   2   1   8   1 
G |  87  25  41  10  97   1   1  23  18  19  12  16  12  56  39   1   5  20  45  57   1  97  96  15   1  52 
T |   1  56  14   1   1  97  14  43  21  27  18   3  41   1  18   7  45  22  11  30  54   1   1  81  88  47 
Position weight matrix (PWM)
A | -3.47 -0.58  0.17  0.99 -3.47 -3.47  0.45  0.03  0.09 -0.29 -3.47  0.82 -0.69 -1.39 -0.37 -3.47  0.12  0.59 -1.39 -1.07  0.30 -3.47 -3.47 -2.37 -2.37 -3.47 
C | -0.49 -2.89 -0.94 -1.79 -2.89 -2.89  0.66 -2.89  0.37  0.48  1.34 -0.69  0.54  0.61  0.15  1.62 -0.33 -2.89  0.69 -2.89 -1.79 -2.89 -2.20 -2.89 -0.81 -2.89 
G |  1.58  0.33  0.82 -0.59  1.68 -2.89 -2.89  0.25  0.00  0.05 -0.41 -0.12 -0.41  1.15  0.77 -2.89 -1.28  0.11  0.92  1.17 -2.89  1.68  1.67 -0.18 -2.89  1.06 
T | -3.47  0.56 -0.83 -3.47 -3.47  1.11 -0.83  0.30 -0.42 -0.17 -0.58 -2.37  0.25 -3.47 -0.58 -1.52  0.34 -0.37 -1.07 -0.06  0.52 -3.47 -3.47  0.93  1.01  0.38 
HAP4Macisaac et. alP = 7.90e-28View matrix ↘
Sequence logo for HAP4
Fisher’s P-value7.90e-28
Information content11.25
Max PWM score12.36
Recommended cutoff9.11
Position frequency matrix (PFM)
A | 0.456 0.001 0.053 0.980 0.989 0.001 0.070 0.903 0.401 0.403 0.240 0.268 0.224 0.226 0.456 
C | 0.127 0.948 0.932 0.001 0.009 0.068 0.658 0.001 0.090 0.191 0.208 0.216 0.318 0.237 0.180 
G | 0.219 0.022 0.001 0.001 0.001 0.001 0.121 0.050 0.397 0.209 0.247 0.235 0.205 0.303 0.165 
T | 0.197 0.029 0.014 0.018 0.001 0.930 0.151 0.046 0.111 0.197 0.305 0.281 0.253 0.234 0.199 
Position count matrix (PCM)
A |  45   0   5  98  98   0   7  90  40  40  24  26  22  22  45 
C |  12  94  93   0   0   6  65   0   9  19  20  21  31  23  18 
G |  21   2   0   0   0   0  12   5  39  20  24  23  20  30  16 
T |  19   2   1   1   0  93  15   4  11  19  30  28  25  23  19 
Position weight matrix (PWM)
A |  0.35 -5.77 -1.80  1.12  1.13 -5.77 -1.52  1.04  0.23  0.23 -0.29 -0.18 -0.36 -0.35  0.35 
C | -0.35  1.66  1.64 -5.19 -3.00 -0.97  1.30 -5.19 -0.69  0.06  0.14  0.18  0.57  0.28  0.00 
G |  0.20 -2.10 -5.19 -5.19 -5.19 -5.19 -0.40 -1.28  0.79  0.15  0.32  0.27  0.13  0.52 -0.09 
T | -0.49 -2.40 -3.13 -2.88 -5.77  1.07 -0.75 -1.94 -1.06 -0.49 -0.05 -0.13 -0.23 -0.31 -0.48 
HAP4Pachkov et alP = 6.69e-20View matrix ↘
Sequence logo for HAP4
Fisher’s P-value6.69e-20
Information content14.45
Max PWM score11.72
Recommended cutoff8.25
Position frequency matrix (PFM)
A | 0.001 0.060 1.000 0.001 0.001 0.001 0.001 0.034 0.051 
C | 0.001 0.006 0.001 0.001 0.001 0.001 0.001 0.443 0.637 
G | 0.001 0.934 0.001 0.001 0.001 1.000 0.927 0.079 0.035 
T | 1.000 0.001 0.001 0.999 0.999 0.001 0.073 0.445 0.277 
Position count matrix (PCM)
A |   0   6 100   0   0   0   0   3   5 
C |   0   0   0   0   0   0   0  44  63 
G |   0  93   0   0   0 100  92   7   3 
T | 100   0   0  99  99   0   7  44  27 
Position weight matrix (PWM)
A | -5.77 -1.67  1.14 -5.77 -5.77 -5.77 -5.77 -2.24 -1.84 
C | -5.19 -3.40 -5.19 -5.19 -5.19 -5.19 -5.19  0.90  1.26 
G | -5.19  1.65 -5.19 -5.19 -5.19  1.71  1.64 -0.82 -1.64 
T |  1.14 -5.77 -5.77  1.14  1.14 -5.77 -1.48  0.33 -0.14 
03 / EXPERIMENTAL CONTEXT

Gene-level annotations and interactions.

Genes bound in ChIP-chip experiments 126 genes

YBL001C, YBL030C, YBL044W, YBL045C, YBL099W, YBL109W, YBL111C, YBL112C, YBL113C, YBR039W, YBR048W, YBR099C, YCL065W, YCL066W, YCL067C, YCR039C, YCR040W, YCR041W, YCR105W, YDL004W, YDL005C, YDL066W, YDL067C, YDL181W, YDR042C, YDR148C, YDR150W, YDR210W-D, YDR298C, YDR299W, YDR377W, YDR473C, YDR474C, YDR529C, YDR543C, YDR544C, YDR545W, YEL001C, YEL008W, YEL009C, YEL024W, YEL025C, YFL001W, YFL002C, YFR001W, YFR033C, YGL001C, YGL103W, YGL104C, YGL187C, YGL191W, YGL193C, YGR183C, YGR296W, YHL049C, YHR001W, YHR001W-A, YHR002W, YHR003C, YHR051W, YHR052W, YHR091C, YHR193C, YHR194W, YIL174W, YIL175W, YJL191W, YJL192C, YJR001W, YJR077C, YJR078W, YJR079W, YJR082C, YJR121W, YKL015W, YKL016C, YKL146W, YKL148C, YLL065W, YLR038C, YLR166C, YLR167W, YLR168C, YLR169W, YLR171W, YLR207W, YLR294C, YLR295C, YLR296W, YLR395C, YLR463C, YLR465C, YLR467W, YML081W, YML088W, YML089C, YML091C, YML119W, YML120C, YML132W, YML133C, YMR194W, YMR256C, YNL052W, YNL054W-A, YNL054W-B, YNL055C, YNL070W, YNL337W, YNL338W, YNL339C, YOL001W, YOL002C, YOR064C, YOR065W, YOR187W, YPL251W, YPL253C, YPL270W, YPL271W, YPL283C, YPR020W, YPR190C, YPR191W, YPR202W, YPR203W

Genes affected by TF deletion 69 genes

YBR158W, YHR143W, YOR065W, YGL168W, YPL240C, YHR051W, YHR053C, YHR055C, YJR147W, YKL016C, YNL143C, YPL078C, YFR016C, YFR006W, YLL065W, YIL156W, YLR286C, YNR067C, YOR263C, YLR131C, YER152C, YER124C, YJR025C, YLR285W, YOR230W, YOR264W, YJR148W, YKR023W, YDR106W, YFL051C, YGR041W, YOR298W, YPL195W, YDL200C, YML091C, YPL092W, YFL021W, YMR110C, YNR001C, YIR015W, YKR093W, YLR042C, YPL066W, YMR027W, YNL066W, YOL028C, YGL028C, YMR173W-A, YPL063W, YHR037W, YIR019C, YOR367W, YOL119C, YHR018C, YMR186W, YOR027W, YOR059C, YDR425W, YGL255W, YMR062C, YBR244W, YKL067W, YLR079W, YLR458W, YMR213W, YDR040C, YLR360W, YOR034C, YNL327W

Genes supported by both experiments 5 genes

YHR051W, YKL016C, YLL065W, YML091C, YOR065W

Predicted TF–TF partners 3 genes

RDS1, RSC3, SUT1

Explore 3 original interaction plots →