← All factors / TF RECORD

HAP1

YLR256W, CYP1

View at SGD ↗

Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus

01 / RECOMMENDED MATRIX

Best-performing DNA-binding model.

RecommendedSource: Aligned Matrix
Fisher’s P-value2.30e-34
Information content10.54
Max PWM score10.94
Recommended cutoff8.27
View and copy the recommended matrices ↘
Position frequency matrix (PFM)
A | 0.021 0.017 0.445 0.462 0.480 0.042 0.738 0.138 0.011 0.040 0.014 
C | 0.014 0.261 0.246 0.097 0.085 0.065 0.042 0.143 0.971 0.043 0.396 
G | 0.935 0.710 0.101 0.265 0.060 0.039 0.038 0.072 0.008 0.891 0.481 
T | 0.030 0.012 0.208 0.176 0.374 0.853 0.183 0.647 0.010 0.026 0.109 
Position count matrix (PCM)
A |   2   1  44  46  48   4  73  13   1   4   1 
C |   1  26  24   9   8   6   4  14  97   4  39 
G |  93  71  10  26   6   3   3   7   0  89  48 
T |   3   1  20  17  37  85  18  64   1   2  10 
Position weight matrix (PWM)
A | -2.72 -2.94  0.33  0.37  0.41 -2.03  0.84 -0.84 -3.37 -2.08 -3.13 
C | -2.55  0.37  0.31 -0.62 -0.75 -1.02 -1.46 -0.23  1.69 -1.43  0.79 
G |  1.65  1.37 -0.58  0.39 -1.10 -1.53 -1.56 -0.92 -3.11  1.60  0.98 
T | -2.37 -3.28 -0.43 -0.60  0.16  0.98 -0.56  0.70 -3.47 -2.51 -1.08 
02 / COMPARATIVE BENCHMARKS

Alternative candidate matrices 6

Historical matrix candidates from the original ScerTF database. Expand a source to inspect its original logo, scores, and matrix values.

HAP1Badis et. al.P = 2.05e-12View matrix ↘
Sequence logo for HAP1
Fisher’s P-value2.05e-12
Information content9.899
Max PWM score9.18
Recommended cutoff4.61
Position frequency matrix (PFM)
A | 0.01 0.01 0.01 0.87 0.05 0.51 0.04 0.57 
C | 0.97 0.01 0.01 0.01 0.26 0.04 0.04 0.11 
G | 0.01 0.97 0.97 0.11 0.53 0.04 0.04 0.11 
T | 0.01 0.01 0.01 0.01 0.16 0.41 0.88 0.21 
Position count matrix (PCM)
A |   1   1   1  87   5  51   4  56 
C |  97   1   1   1  26   4   4  11 
G |   1  97  97  11  53   4   4  11 
T |   1   1   1   1  16  41  88  21 
Position weight matrix (PWM)
A | -3.47 -3.47 -3.47  1.00 -1.86  0.47 -2.08  0.58 
C |  1.68 -2.89 -2.89 -2.89  0.37 -1.50 -1.50 -0.49 
G | -2.89  1.68  1.68 -0.49  1.08 -1.50 -1.50 -0.49 
T | -3.47 -3.47 -3.47 -3.47 -0.69  0.25  1.01 -0.42 
HAP1Foat et. al.P = 1.22e-18View matrix ↘
Sequence logo for HAP1
Fisher’s P-value1.22e-18
Information content10.64
Max PWM score10.83
Recommended cutoff5.7
Position frequency matrix (PFM)
A | 0.42 0.01 0.01 0.13 0.81 0.03 0.94 0.37 0.70 0.65 
C | 0.02 0.76 0.97 0.01 0.11 0.01 0.04 0.32 0.09 0.19 
G | 0.48 0.22 0.01 0.86 0.01 0.01 0.01 0.01 0.12 0.03 
T | 0.09 0.01 0.01 0.01 0.07 0.95 0.01 0.31 0.09 0.13 
Position count matrix (PCM)
A |  42   1   1  13  81   3  94  37  70  65 
C |   2  76  97   1  11   1   4  32   9  19 
G |  48  22   1  86   1   1   1   1  12   3 
T |   9   1   1   1   7  95   1  31   9  13 
Position weight matrix (PWM)
A |  0.27 -3.47 -3.47 -0.90  0.93 -2.37  1.08  0.15  0.78  0.71 
C | -2.20  1.44  1.68 -2.89 -0.49 -2.89 -1.50  0.58 -0.69  0.05 
G |  0.98  0.20 -2.89  1.56 -2.89 -2.89 -2.89 -2.89 -0.41 -1.79 
T | -1.27 -3.47 -3.47 -3.47 -1.52  1.09 -3.47 -0.03 -1.27 -0.90 
HAP1Harbison et. al.P = 3.61e-34View matrix ↘
Sequence logo for HAP1
Fisher’s P-value3.61e-34
Information content12.94
Max PWM score12.24
Recommended cutoff9.14
Position frequency matrix (PFM)
A | 0.009 0.024 0.580 0.583 0.663 0.066 0.871 0.226 0.016 0.025 0.020 
C | 0.019 0.021 0.253 0.064 0.033 0.062 0.012 0.172 0.973 0.007 0.329 
G | 0.955 0.948 0.076 0.242 0.012 0.040 0.009 0.103 0.004 0.960 0.616 
T | 0.017 0.007 0.092 0.111 0.292 0.832 0.107 0.499 0.007 0.008 0.036 
Position count matrix (PCM)
A |   0   2  57  58  66   6  87  22   1   2   2 
C |   1   2  25   6   3   6   1  17  97   0  32 
G |  95  94   7  24   1   4   0  10   0  96  61 
T |   1   0   9  11  29  83  10  49   0   0   3 
Position weight matrix (PWM)
A | -3.57 -2.59  0.59  0.60  0.73 -1.58  1.00 -0.35 -3.00 -2.55 -2.77 
C | -2.25 -2.15  0.34 -1.03 -1.70 -1.07 -2.71 -0.05  1.69 -3.25  0.60 
G |  1.67  1.66 -0.86  0.30 -2.71 -1.50 -3.00 -0.56 -3.81  1.67  1.23 
T | -2.94 -3.82 -1.25 -1.06 -0.09  0.96 -1.10  0.44 -3.82 -3.69 -2.18 
HAP1Macisaac et. alP = 6.51e-31View matrix ↘
Sequence logo for HAP1
Fisher’s P-value6.51e-31
Information content9.12
Max PWM score10
Recommended cutoff6.84
Position frequency matrix (PFM)
A | 0.001 0.046 0.673 0.217 0.859 0.628 0.204 0.257 0.026 0.054 
C | 0.919 0.001 0.014 0.036 0.037 0.039 0.281 0.192 0.648 0.845 
G | 0.065 0.943 0.148 0.023 0.063 0.069 0.139 0.155 0.264 0.053 
T | 0.015 0.010 0.165 0.724 0.041 0.264 0.376 0.396 0.062 0.048 
Position count matrix (PCM)
A |   0   4  67  21  85  62  20  25   2   5 
C |  91   0   1   3   3   3  28  19  64  84 
G |   6  94  14   2   6   6  13  15  26   5 
T |   1   1  16  72   4  26  37  39   6   4 
Position weight matrix (PWM)
A | -5.77 -1.94  0.74 -0.39  0.99  0.67 -0.45 -0.22 -2.51 -1.78 
C |  1.63 -5.19 -2.55 -1.61 -1.58 -1.53  0.45  0.06  1.28  1.55 
G | -1.02  1.66 -0.20 -2.06 -1.05 -0.96 -0.26 -0.15  0.38 -1.22 
T | -3.06 -3.47 -0.66  0.82 -2.05 -0.19  0.16  0.21 -1.64 -1.90 
HAP1Morozov et. al.P = 3.30e-31View matrix ↘
Sequence logo for HAP1
Fisher’s P-value3.30e-31
Information content10.47
Max PWM score11.71
Recommended cutoff7.47
Position frequency matrix (PFM)
A | 0.108 0.033 0.010 0.310 0.341 0.297 0.018 0.604 0.050 0.007 0.054 0.008 
C | 0.619 0.010 0.500 0.239 0.130 0.137 0.069 0.071 0.115 0.969 0.079 0.464 
G | 0.120 0.915 0.472 0.127 0.288 0.109 0.039 0.066 0.041 0.012 0.822 0.347 
T | 0.153 0.042 0.017 0.324 0.241 0.457 0.875 0.259 0.794 0.013 0.045 0.182 
Position count matrix (PCM)
A |  10   3   1  31  34  29   1  60   5   0   5   0 
C |  61   1  50  23  13  13   6   7  11  96   7  46 
G |  12  91  47  12  28  10   3   6   4   1  82  34 
T |  15   4   1  32  24  45  87  25  79   1   4  18 
Position weight matrix (PWM)
A | -1.09 -2.27 -3.47 -0.03  0.06 -0.07 -2.88  0.64 -1.86 -3.82 -1.78 -3.69 
C |  1.24 -2.89  1.02  0.28 -0.33 -0.27 -0.96 -0.93 -0.45  1.68 -0.82  0.95 
G | -0.41  1.63  0.96 -0.35  0.47 -0.50 -1.53 -1.00 -1.48 -2.71  1.52  0.66 
T | -0.74 -2.03 -2.94  0.01 -0.28  0.36  1.01 -0.21  0.91 -3.20 -1.96 -0.56 
HAP1Pachkov et alP = 2.23e-33View matrix ↘
Sequence logo for HAP1
Fisher’s P-value2.23e-33
Information content15.63
Max PWM score14.99
Recommended cutoff9.51
Position frequency matrix (PFM)
A | 0.028 0.001 0.012 0.567 0.197 0.931 0.365 0.087 0.040 0.001 0.001 0.107 0.110 0.151 0.172 
C | 0.550 1.000 0.001 0.121 0.025 0.036 0.084 0.325 0.115 0.979 1.000 0.199 0.320 0.286 0.357 
G | 0.422 0.001 0.988 0.149 0.001 0.032 0.001 0.027 0.237 0.001 0.001 0.483 0.338 0.236 0.336 
T | 0.001 0.001 0.001 0.163 0.779 0.001 0.551 0.561 0.608 0.021 0.001 0.211 0.232 0.326 0.135 
Position count matrix (PCM)
A |   2   0   1  56  19  93  36   8   4   0   0  10  11  15  17 
C |  55 100   0  12   2   3   8  32  11  97 100  19  32  28  35 
G |  42   0  98  14   0   3   0   2  23   0   0  48  33  23  33 
T |   0   0   0  16  77   0  55  56  60   2   0  21  23  32  13 
Position weight matrix (PWM)
A | -2.44 -5.77 -3.28  0.57 -0.49  1.07  0.13 -1.30 -2.08 -5.77 -5.77 -1.10 -1.07 -0.75 -0.62 
C |  1.12  1.71 -5.19 -0.40 -1.97 -1.61 -0.76  0.59 -0.45  1.69  1.71  0.10  0.58  0.46  0.68 
G |  0.85 -5.19  1.70 -0.19 -5.19 -1.73 -5.19 -1.90  0.28 -5.19 -5.19  0.99  0.63  0.27  0.62 
T | -5.77 -5.77 -5.77 -0.67  0.89 -5.77  0.54  0.56  0.64 -2.72 -5.77 -0.42 -0.32  0.02 -0.86 
03 / EXPERIMENTAL CONTEXT

Gene-level annotations and interactions.

Genes bound in ChIP-chip experiments 215 genes

YAL039C, YAR050W, YBL043W, YBL044W, YBL045C, YBL095W, YBR015C, YBR016W, YBR083W, YCL036W, YCL037C, YCR061W, YCR062W, YDL017W, YDL018C, YDL037C, YDL086W, YDL087C, YDL110C, YDL173W, YDL174C, YDR218C, YDR233C, YDR234W, YDR252W, YDR256C, YDR284C, YDR285W, YDR490C, YDR492W, YDR504C, YDR505C, YDR529C, YDR543C, YDR544C, YDR545W, YEL024W, YEL025C, YEL033W, YEL034W, YEL035C, YEL036C, YEL038W, YEL039C, YER001W, YER044C, YER048C, YER053C, YER141W, YER145C, YER146W, YER189W, YER190W, YFL010W-A, YFL045C, YFL058W, YFR033C, YGL001C, YGL055W, YGL056C, YGL160W, YGL161C, YGL187C, YGL191W, YGL193C, YGL228W, YGL229C, YGR035C, YGR049W, YGR060W, YGR088W, YGR110W, YGR175C, YGR176W, YGR177C, YGR183C, YGR234W, YGR248W, YGR249W, YGR264C, YGR266W, YGR296W, YHL024W, YHR001W-A, YHR005C-A, YHR007C, YHR051W, YHR091C, YHR190W, YIL155C, YIL177C, YIR002C, YIR003W, YJL048C, YJL100W, YJL101C, YJR047C, YJR048W, YJR104C, YJR105W, YKL019W, YKL020C, YKL051W, YKL052C, YKL096W-A, YKL097C, YKL109W, YKL182W, YKL217W, YKR040C, YKR042W, YKR046C, YKR047W, YKR087C, YLL033W, YLL034C, YLR049C, YLR099C, YLR100W, YLR108C, YLR109W, YLR110C, YLR111W, YLR112W, YLR139C, YLR142W, YLR153C, YLR154C, YLR205C, YLR206W, YLR213C, YLR214W, YLR228C, YLR255C, YLR256W, YLR256W-A, YLR325C, YLR326W, YLR342W, YLR395C, YLR410W-A, YLR410W-B, YLR463C, YLR465C, YLR467W, YML007W, YML008C, YML028W, YML036W, YML037C, YML052W, YML053C, YML054C, YML075C, YML076C, YML116W, YML126C, YMR015C, YMR037C, YMR056C, YMR070W, YMR134W, YMR135W-A, YMR145C, YMR201C, YMR202W, YMR220W, YMR238W, YMR251W-A, YMR256C, YMR272C, YMR282C, YMR302C, YNL009W, YNL052W, YNL101W, YNL111C, YNL155W, YNL156C, YNL231C, YNL237W, YNL332W, YNL337W, YNL338W, YNL339C, YNR016C, YNR017W, YNR019W, YNR041C, YNR043W, YNR060W, YOL027C, YOL028C, YOL109W, YOL113W, YOL114C, YOR018W, YOR064C, YOR065W, YOR317W, YOR348C, YOR349W, YOR356W, YPL028W, YPL116W, YPL117C, YPL218W, YPL231W, YPL283C, YPR013C, YPR063C, YPR064W, YPR065W, YPR149W, YPR151C

Genes affected by TF deletion 1 genes

No Data

Predicted TF–TF partners 1 genes

RSF2

Explore 1 original interaction plots →