← All factors / TF RECORD

FHL1

YPR104C, SPP42

View at SGD ↗

Regulator of ribosomal protein transcription; has forkhead associated domain that binds phosphorylated proteins; also has forkhead DNA-binding domain but does not bind DNA in vitro; suppresses RNA pol III and splicing factor prp4 mutants

01 / RECOMMENDED MATRIX

Best-performing DNA-binding model.

RecommendedSource: Zhu et. al.
Fisher’s P-value2.44e-10
Information content10.96
Max PWM score9.8
Recommended cutoff4.92
View and copy the recommended matrices ↘
Position frequency matrix (PFM)
A | 0.05 0.92 0.01 0.01 0.01 0.90 0.65 0.51 
C | 0.10 0.01 0.97 0.01 0.97 0.01 0.21 0.09 
G | 0.84 0.02 0.01 0.93 0.01 0.07 0.05 0.04 
T | 0.02 0.04 0.01 0.05 0.01 0.02 0.09 0.37 
Position count matrix (PCM)
A |   5  92   1   1   1  90  65  51 
C |  10   1  97   1  97   1  21   9 
G |  84   2   1  93   1   7   5   4 
T |   2   4   1   5   1   2   9  37 
Position weight matrix (PWM)
A | -1.86  1.06 -3.47 -3.47 -3.47  1.03  0.71  0.47 
C | -0.59 -2.89  1.68 -2.89  1.68 -2.89  0.15 -0.69 
G |  1.54 -2.20 -2.89  1.64 -2.89 -0.94 -1.28 -1.50 
T | -2.77 -2.08 -3.47 -1.86 -3.47 -2.77 -1.27  0.15 
02 / COMPARATIVE BENCHMARKS

Alternative candidate matrices 10

Historical matrix candidates from the original ScerTF database. Expand a source to inspect its original logo, scores, and matrix values.

FHL1Badis et. al.P = 6.29e-11View matrix ↘
Sequence logo for FHL1
Fisher’s P-value6.29e-11
Information content10.93
Max PWM score8.75
Recommended cutoff4.75
Position frequency matrix (PFM)
A | 0.01 0.97 0.01 0.01 0.01 0.88 
C | 0.10 0.01 0.97 0.01 0.97 0.01 
G | 0.88 0.01 0.01 0.97 0.01 0.01 
T | 0.01 0.01 0.01 0.01 0.01 0.10 
Position count matrix (PCM)
A |   1  97   1   1   1  88 
C |  10   1  97   1  97   1 
G |  88   1   1  97   1   1 
T |   1   1   1   1   1  10 
Position weight matrix (PWM)
A | -3.47  1.11 -3.47 -3.47 -3.47  1.01 
C | -0.59 -2.89  1.68 -2.89  1.68 -2.89 
G |  1.59 -2.89 -2.89  1.68 -2.89 -2.89 
T | -3.47 -3.47 -3.47 -3.47 -3.47 -1.16 
FHL1_AFoat et. al.P = 1.13e-84View matrix ↘
Sequence logo for FHL1_A
Fisher’s P-value1.13e-84
Information content11.85
Max PWM score12.76
Recommended cutoff8.57
Position frequency matrix (PFM)
A | 0.34 0.47 0.37 0.01 0.01 0.21 0.45 0.05 0.05 0.01 0.44 0.04 0.01 
C | 0.03 0.20 0.01 0.05 0.01 0.43 0.16 0.38 0.01 0.01 0.01 0.27 0.13 
G | 0.43 0.11 0.45 0.26 0.96 0.01 0.01 0.01 0.93 0.97 0.55 0.01 0.50 
T | 0.21 0.23 0.18 0.68 0.02 0.36 0.38 0.57 0.01 0.01 0.01 0.68 0.37 
Position count matrix (PCM)
A |  34  47  37   1   1  21  45   5   5   1  44   4   1 
C |   3  20   1   5   1  43  16  38   1   1   1  27  13 
G |  43  11  45  26  96   1   1   1  93  97  55   1  50 
T |  21  23  18  68   2  36  38  56   1   1   1  68  37 
Position weight matrix (PWM)
A |  0.06  0.38  0.15 -3.47 -3.47 -0.42  0.34 -1.86 -1.86 -3.47  0.32 -2.08 -3.47 
C | -1.79  0.11 -2.89 -1.28 -2.89  0.87 -0.12  0.75 -2.89 -2.89 -2.89  0.41 -0.33 
G |  0.87 -0.49  0.92  0.37  1.67 -2.89 -2.89 -2.89  1.64  1.68  1.12 -2.89  1.02 
T | -0.42 -0.33 -0.58  0.75 -2.77  0.12  0.17  0.58 -3.47 -3.47 -3.47  0.75  0.15 
FHL1_BFoat et. al.P = 0.463View matrix ↘
Sequence logo for FHL1_B
Fisher’s P-value0.463
Information content21.2
Max PWM score24.84
Recommended cutoff13
Position frequency matrix (PFM)
A | 0.06 0.13 0.40 0.01 0.01 0.01 0.38 0.10 0.33 0.28 0.58 0.12 0.72 0.32 0.07 0.23 0.68 0.19 0.16 0.15 0.01 0.01 0.01 0.25 0.03 0.59 
C | 0.55 0.38 0.16 0.01 0.96 0.01 0.02 0.77 0.25 0.25 0.14 0.33 0.11 0.09 0.14 0.21 0.24 0.20 0.41 0.15 0.01 0.91 0.01 0.05 0.14 0.17 
G | 0.30 0.09 0.11 0.97 0.02 0.97 0.07 0.06 0.38 0.21 0.18 0.35 0.14 0.36 0.34 0.37 0.08 0.60 0.11 0.02 0.97 0.03 0.97 0.23 0.54 0.12 
T | 0.10 0.40 0.33 0.01 0.01 0.01 0.52 0.07 0.04 0.26 0.10 0.19 0.03 0.23 0.45 0.18 0.01 0.01 0.31 0.68 0.01 0.04 0.01 0.47 0.29 0.11 
Position count matrix (PCM)
A |   6  13  40   1   1   1  38  10  33  28  57  12  72  32   7  23  68  19  16  15   1   1   1  25   3  59 
C |  55  38  16   1  96   1   2  77  25  25  14  33  11   9  14  21  24  20  41  15   1  91   1   5  14  17 
G |  30   9  11  97   2  97   7   6  38  21  18  35  14  36  34  37   8  60  11   2  97   3  97  23  54  12 
T |  10  40  33   1   1   1  52   7   4  26  10  19   3  23  45  18   1   1  31  68   1   4   1  47  28  11 
Position weight matrix (PWM)
A | -1.67 -0.90  0.22 -3.47 -3.47 -3.47  0.17 -1.16  0.03 -0.13  0.59 -0.98  0.81  0.00 -1.52 -0.33  0.75 -0.52 -0.69 -0.76 -3.47 -3.47 -3.47 -0.25 -2.37  0.61 
C |  1.12  0.75 -0.12 -2.89  1.67 -2.89 -2.20  1.45  0.33  0.33 -0.25  0.61 -0.49 -0.69 -0.25  0.15  0.29  0.11  0.82 -0.18 -2.89  1.62 -2.89 -1.28 -0.25 -0.06 
G |  0.51 -0.69 -0.49  1.68 -2.20  1.68 -0.94 -1.10  0.75  0.15  0.00  0.66 -0.25  0.69  0.64  0.72 -0.81  1.20 -0.49 -2.20  1.68 -1.79  1.68  0.25  1.10 -0.41 
T | -1.16  0.22  0.03 -3.47 -3.47 -3.47  0.49 -1.52 -2.08 -0.21 -1.16 -0.52 -2.37 -0.33  0.34 -0.58 -3.47 -3.47 -0.03  0.75 -3.47 -2.08 -3.47  0.38 -0.10 -1.07 
FHL1_CFoat et. al.P = 0.5224View matrix ↘
Sequence logo for FHL1_C
Fisher’s P-value0.5224
Information content22.15
Max PWM score25.02
Recommended cutoff13.96
Position frequency matrix (PFM)
A | 0.04 0.01 0.01 0.07 0.26 0.27 0.10 0.34 0.30 0.50 0.24 0.05 0.12 0.02 0.04 0.20 0.01 0.01 0.01 0.07 0.10 0.04 
C | 0.50 0.97 0.96 0.01 0.24 0.01 0.03 0.09 0.35 0.01 0.07 0.38 0.21 0.88 0.52 0.53 0.74 0.02 0.97 0.05 0.27 0.18 
G | 0.24 0.01 0.01 0.91 0.35 0.35 0.44 0.55 0.26 0.33 0.57 0.39 0.44 0.06 0.06 0.22 0.25 0.96 0.01 0.64 0.26 0.77 
T | 0.21 0.01 0.02 0.01 0.15 0.37 0.43 0.02 0.08 0.16 0.11 0.18 0.23 0.05 0.39 0.04 0.01 0.01 0.01 0.24 0.36 0.01 
Position count matrix (PCM)
A |   4   1   1   7  26  27  10  34  30  50  24   5  12   2   4  20   1   1   1   7  10   4 
C |  50  97  96   1  24   1   3   9  35   1   7  38  21  88  52  53  74   2  97   5  27  18 
G |  24   1   1  91  35  35  44  55  26  33  56  39  44   6   6  22  25  96   1  64  26  77 
T |  21   1   2   1  15  37  43   2   8  16  11  18  23   5  39   4   1   1   1  24  36   1 
Position weight matrix (PWM)
A | -2.08 -3.47 -3.47 -1.52 -0.21 -0.17 -1.16  0.06 -0.06  0.45 -0.29 -1.86 -0.98 -2.77 -2.08 -0.47 -3.47 -3.47 -3.47 -1.52 -1.16 -2.08 
C |  1.02  1.68  1.67 -2.89  0.29 -2.89 -1.79 -0.69  0.66 -2.89 -0.94  0.75  0.15  1.59  1.06  1.08  1.41 -2.20  1.68 -1.28  0.41  0.00 
G |  0.29 -2.89 -2.89  1.62  0.66  0.66  0.89  1.12  0.37  0.61  1.15  0.77  0.89 -1.10 -1.10  0.20  0.33  1.67 -2.89  1.27  0.37  1.45 
T | -0.42 -3.47 -2.77 -3.47 -0.76  0.15  0.30 -2.77 -1.39 -0.69 -1.07 -0.58 -0.33 -1.86  0.20 -2.08 -3.47 -3.47 -3.47 -0.29  0.12 -3.47 
FHL1_DFoat et. al.P = 1.69e-41View matrix ↘
Sequence logo for FHL1_D
Fisher’s P-value1.69e-41
Information content18.3
Max PWM score16.48
Recommended cutoff9.41
Position frequency matrix (PFM)
A | 0.37 0.44 0.01 0.01 0.01 0.03 0.01 0.50 0.01 0.93 0.01 0.08 0.01 
C | 0.59 0.44 0.01 0.97 0.97 0.01 0.05 0.01 0.97 0.06 0.02 0.84 0.34 
G | 0.04 0.12 0.01 0.01 0.01 0.95 0.62 0.49 0.01 0.01 0.01 0.01 0.24 
T | 0.01 0.01 0.97 0.01 0.01 0.01 0.32 0.01 0.01 0.01 0.96 0.07 0.42 
Position count matrix (PCM)
A |  37  44   1   1   1   3   1  50   1  93   1   8   1 
C |  59  44   1  97  97   1   5   1  97   6   2  84  34 
G |   4  12   1   1   1  95  62  49   1   1   1   1  24 
T |   1   1  97   1   1   1  32   1   1   1  96   7  42 
Position weight matrix (PWM)
A |  0.15  0.32 -3.47 -3.47 -3.47 -2.37 -3.47  0.45 -3.47  1.07 -3.47 -1.39 -3.47 
C |  1.19  0.89 -2.89  1.68  1.68 -2.89 -1.28 -2.89  1.68 -1.10 -2.20  1.54  0.64 
G | -1.50 -0.41 -2.89 -2.89 -2.89  1.66  1.24  1.00 -2.89 -2.89 -2.89 -2.89  0.29 
T | -3.47 -3.47  1.11 -3.47 -3.47 -3.47  0.00 -3.47 -3.47 -3.47  1.10 -1.52  0.27 
FHL1Harbison et. al.P = 1.25e-110View matrix ↘
Sequence logo for FHL1
Fisher’s P-value1.25e-110
Information content11.85
Max PWM score12.45
Recommended cutoff8.63
Position frequency matrix (PFM)
A | 0.570 0.052 0.022 0.016 0.773 0.041 0.068 0.006 0.496 0.069 0.115 
C | 0.085 0.032 0.009 0.123 0.045 0.527 0.009 0.003 0.023 0.047 0.085 
G | 0.195 0.064 0.948 0.023 0.067 0.008 0.902 0.984 0.446 0.065 0.577 
T | 0.150 0.852 0.021 0.839 0.115 0.424 0.021 0.007 0.034 0.819 0.223 
Position count matrix (PCM)
A |  56   5   2   1  77   4   6   0  49   6  11 
C |   8   3   0  12   4  52   0   0   2   4   8 
G |  19   6  94   2   6   0  90  98  44   6  57 
T |  15  85   2  83  11  42   2   0   3  81  22 
Position weight matrix (PWM)
A |  0.58 -1.82 -2.68 -3.00  0.88 -2.05 -1.55 -3.98  0.44 -1.53 -1.02 
C | -0.75 -1.73 -3.00 -0.38 -1.39  1.07 -3.00 -4.09 -2.06 -1.34 -0.75 
G |  0.08 -1.03  1.66 -2.06 -0.99 -3.11  1.61  1.70  0.91 -1.02  1.16 
T | -0.76  0.98 -2.72  0.96 -1.02  0.28 -2.72 -3.82 -2.24  0.94 -0.36 
FHL1Macisaac et. alP = 4.55e-95View matrix ↘
Sequence logo for FHL1
Fisher’s P-value4.55e-95
Information content11.94
Max PWM score11.57
Recommended cutoff7.42
Position frequency matrix (PFM)
A | 0.702 0.009 0.009 0.005 0.828 0.056 0.157 0.011 0.578 0.046 
C | 0.032 0.005 0.005 0.111 0.051 0.706 0.014 0.005 0.059 0.042 
G | 0.191 0.090 0.976 0.042 0.048 0.009 0.795 0.965 0.336 0.060 
T | 0.075 0.896 0.010 0.842 0.073 0.229 0.034 0.019 0.027 0.852 
Position count matrix (PCM)
A |  70   0   0   0  82   5  15   1  57   4 
C |   3   0   0  11   5  70   1   0   5   4 
G |  19   9  97   4   4   0  79  96  33   6 
T |   7  89   1  84   7  22   3   1   2  85 
Position weight matrix (PWM)
A |  0.79 -3.57 -3.57 -4.16  0.95 -1.74 -0.71 -3.37  0.59 -1.94 
C | -1.73 -3.58 -3.58 -0.48 -1.26  1.37 -2.55 -3.58 -1.12 -1.46 
G |  0.06 -0.69  1.69 -1.46 -1.32 -3.00  1.49  1.68  0.62 -1.10 
T | -1.45  1.03 -3.47  0.97 -1.48 -0.33 -2.24 -2.82 -2.47  0.98 
FHL1Morozov et. al.P = 3.34e-127View matrix ↘
Sequence logo for FHL1
Fisher’s P-value3.34e-127
Information content14.28
Max PWM score14.17
Recommended cutoff9.38
Position frequency matrix (PFM)
A | 0.249 0.320 0.651 0.251 0.978 0.061 0.016 0.109 0.443 0.059 0.927 0.007 0.959 
C | 0.118 0.088 0.046 0.697 0.016 0.447 0.960 0.810 0.009 0.048 0.003 0.984 0.031 
G | 0.103 0.059 0.146 0.041 0.002 0.017 0.016 0.012 0.519 0.040 0.068 0.002 0.008 
T | 0.530 0.533 0.157 0.010 0.003 0.475 0.008 0.069 0.029 0.852 0.002 0.007 0.002 
Position count matrix (PCM)
A |  24  32  65  25  97   6   1  10  44   5  92   0  95 
C |  11   8   4  69   1  44  96  81   0   4   0  98   3 
G |  10   5  14   4   0   1   1   1  51   4   6   0   0 
T |  53  53  15   1   0  47   0   6   2  85   0   0   0 
Position weight matrix (PWM)
A | -0.25  0.00  0.71 -0.24  1.12 -1.66 -3.00 -1.08  0.33 -1.69  1.06 -3.82  1.10 
C | -0.42 -0.72 -1.36  1.35 -2.42  0.91  1.67  1.50 -3.00 -1.32 -4.09  1.70 -1.76 
G | -0.56 -1.12 -0.21 -1.48 -4.50 -2.36 -2.42 -2.71  1.06 -1.50 -0.97 -4.50 -3.11 
T |  0.50  0.51 -0.71 -3.47 -4.67  0.39 -3.69 -1.53 -2.40  0.98 -5.08 -3.82 -5.08 
FHL1Pachkov et alP = 1.73e-10View matrix ↘
Sequence logo for FHL1
Fisher’s P-value1.73e-10
Information content11.32
Max PWM score12.49
Recommended cutoff7.01
Position frequency matrix (PFM)
A | 0.571 0.161 0.409 0.200 0.216 0.226 0.961 0.001 0.014 0.001 0.367 
C | 0.156 0.293 0.087 0.306 0.093 0.040 0.001 0.710 0.040 0.611 0.013 
G | 0.198 0.547 0.454 0.194 0.691 0.734 0.039 0.001 0.933 0.001 0.620 
T | 0.076 0.001 0.049 0.300 0.001 0.001 0.001 0.290 0.013 0.389 0.001 
Position count matrix (PCM)
A |  57  16  40  20  21  22  96   0   1   0  36 
C |  15  29   8  30   9   4   0  71   4  61   1 
G |  19  54  45  19  69  73   3   0  93   0  62 
T |   7   0   4  30   0   0   0  28   1  38   0 
Position weight matrix (PWM)
A |  0.58 -0.69  0.25 -0.47 -0.39 -0.35  1.10 -5.77 -3.13 -5.77  0.14 
C | -0.14  0.49 -0.73  0.53 -0.66 -1.50 -5.19  1.37 -1.50  1.22 -2.63 
G |  0.10  1.11  0.93  0.07  1.35  1.41 -1.53 -5.19  1.65 -5.19  1.24 
T | -1.44 -5.77 -1.88 -0.06 -5.77 -5.77 -5.77 -0.10 -3.20  0.20 -5.77 
FHL1Zhao and StormoP = 1.67e-13View matrix ↘
Sequence logo for FHL1
Fisher’s P-value1.67e-13
Information content5.818
Max PWM score6.81
Recommended cutoff5.73
Position frequency matrix (PFM)
A | 0.196 0.605 0.086 0.061 0.044 0.620 
C | 0.246 0.116 0.824 0.001 0.943 0.060 
G | 0.440 0.134 0.001 0.758 0.001 0.215 
T | 0.119 0.145 0.089 0.180 0.012 0.105 
Position count matrix (PCM)
A |  19  60   8   6   4  62 
C |  24  11  82   0  94   6 
G |  44  13   0  75   0  21 
T |  11  14   8  18   1  10 
Position weight matrix (PWM)
A | -0.49  0.64 -1.31 -1.66 -1.98  0.66 
C |  0.31 -0.44  1.52 -5.19  1.66 -1.10 
G |  0.89 -0.30 -5.19  1.44 -5.19  0.18 
T | -0.99 -0.79 -1.28 -0.58 -3.28 -1.11 
03 / EXPERIMENTAL CONTEXT

Gene-level annotations and interactions.

Genes bound in ChIP-chip experiments 207 genes

YAL022C, YBL072C, YBL087C, YBL092W, YBL093C, YBR012W-A, YBR012W-B, YBR084C-A, YBR085W, YBR116C, YBR117C, YBR118W, YBR126C, YBR181C, YBR184W, YBR188C, YBR189W, YBR190W, YBR191W, YDL060W, YDL061C, YDL075W, YDL076C, YDL082W, YDL083C, YDL130W, YDL133W, YDL136W, YDL183C, YDL184C, YDL191W, YDR024W, YDR025W, YDR064W, YDR159W, YDR384C, YDR385W, YDR418W, YDR447C, YDR448W, YDR449C, YDR450W, YDR470C, YDR471W, YDR500C, YDR501W, YEL008W, YEL009C, YEL054C, YER056C-A, YER074W, YER101C, YER102W, YER116C, YER117W, YER130C, YER131W, YFL034W, YFR031C-A, YGL030W, YGL031C, YGL100W, YGL103W, YGL104C, YGL123W, YGL124C, YGL134W, YGL135W, YGL136C, YGL147C, YGL188C, YGL189C, YGR027C, YGR033C, YGR034W, YGR084C, YGR085C, YGR117C, YGR118W, YGR148C, YGR149W, YGR213C, YGR214W, YHL001W, YHL015W, YHL016C, YHL033C, YHR021C, YHR021W-A, YHR141C, YHR142W, YHR203C, YHR204W, YIL018W, YIL069C, YIL133C, YIL148W, YIL149C, YJL134W, YJL135W, YJL136C, YJL177W, YJL178C, YJL189W, YJL190C, YJL191W, YJL192C, YJR123W, YJR145C, YJR146W, YJR147W, YKL006C-A, YKL006W, YKL156W, YKL180W, YKR057W, YKR094C, YKR095W, YLL043W, YLL045C, YLR029C, YLR030W, YLR047C, YLR048W, YLR061W, YLR074C, YLR075W, YLR149C, YLR150W, YLR166C, YLR167W, YLR183C, YLR184W, YLR185W, YLR264W, YLR287C-A, YLR325C, YLR326W, YLR333C, YLR340W, YLR344W, YLR367W, YLR387C, YLR388W, YLR406C, YLR407W, YLR441C, YLR447C, YLR448W, YLR452C, YML024W, YML025C, YML026C, YML063W, YML064C, YML073C, YMR013C, YMR116C, YMR142C, YMR143W, YMR194W, YMR229C, YMR230W, YMR242C, YNL067W, YNL068C, YNL069C, YNL096C, YNL162W, YNL163C, YNL178W, YNL302C, YOL039W, YOL040C, YOL120C, YOL121C, YOL127W, YOL128C, YOR095C, YOR096W, YOR161C, YOR182C, YOR183W, YOR234C, YOR236W, YOR292C, YOR293W, YOR312C, YOR354C, YOR355W, YOR369C, YPL079W, YPL080C, YPL081W, YPL082C, YPL090C, YPL131W, YPL143W, YPL199C, YPL220W, YPR042C, YPR043W, YPR080W, YPR102C, YPR103W, YPR131C, YPR132W

Genes affected by TF deletion 1 genes

No Data

Predicted TF–TF partners 3 genes

AFT2, RAP1, SFP1

Explore 3 original interaction plots →