← All factors / TF RECORD
ECM22
YLR228C
Sterol regulatory element binding protein, regulates transcription of sterol biosynthetic genes; contains Zn[2]-Cys[6] binuclear cluster; homologous to Upc2p; relocates from intracellular membranes to perinuclear foci on sterol depletion
01 / RECOMMENDED MATRIX
Best-performing DNA-binding model.
Fisher’s P-value0.5252
Information content15.71
Max PWM score15.97
Recommended cutoff7.98
View and copy the recommended matrices ↘
Position frequency matrix (PFM)
A | 0.06 0.01 0.01 0.04 0.24 0.14 0.23 0.23 0.35 0.02 0.01 0.02 0.92 C | 0.53 0.78 0.03 0.01 0.02 0.26 0.30 0.08 0.42 0.93 0.04 0.02 0.01 G | 0.13 0.20 0.94 0.94 0.71 0.16 0.35 0.42 0.11 0.01 0.94 0.95 0.05 T | 0.29 0.01 0.01 0.01 0.02 0.44 0.13 0.27 0.12 0.04 0.01 0.01 0.02
Position count matrix (PCM)
A | 6 1 1 4 24 14 23 23 35 2 1 2 92 C | 53 78 3 1 2 26 30 8 42 93 4 2 1 G | 13 20 94 94 71 16 35 42 11 1 94 95 5 T | 28 1 1 1 2 44 13 27 12 4 1 1 2
Position weight matrix (PWM)
A | -1.67 -3.47 -3.47 -2.08 -0.29 -0.83 -0.33 -0.33 0.09 -2.77 -3.47 -2.77 1.06 C | 1.08 1.47 -1.79 -2.89 -2.20 0.37 0.51 -0.81 0.85 1.64 -1.50 -2.20 -2.89 G | -0.33 0.11 1.65 1.65 1.37 -0.12 0.66 0.85 -0.49 -2.89 1.65 1.66 -1.28 T | -0.10 -3.47 -3.47 -3.47 -2.77 0.32 -0.90 -0.17 -0.98 -2.08 -3.47 -3.47 -2.77
02 / COMPARATIVE BENCHMARKS
Alternative candidate matrices 4
Historical matrix candidates from the original ScerTF database. Expand a source to inspect its original logo, scores, and matrix values.
ECM22Badis et. al.P = 0.02047View matrix ↘
Fisher’s P-value0.02047
Information content9.425
Max PWM score8.3
Recommended cutoff4.18
Position frequency matrix (PFM)
A | 0.14 0.01 0.01 0.01 0.01 0.91 C | 0.07 0.97 0.97 0.14 0.01 0.01 G | 0.07 0.01 0.01 0.84 0.84 0.07 T | 0.72 0.01 0.01 0.01 0.14 0.01
Position count matrix (PCM)
A | 14 1 1 1 1 91 C | 7 97 97 14 1 1 G | 7 1 1 84 84 7 T | 72 1 1 1 14 1
Position weight matrix (PWM)
A | -0.83 -3.47 -3.47 -3.47 -3.47 1.05 C | -0.94 1.68 1.68 -0.25 -2.89 -2.89 G | -0.94 -2.89 -2.89 1.54 1.54 -0.94 T | 0.81 -3.47 -3.47 -3.47 -0.83 -3.47
ECM22Foat et. al.P = 0.8044View matrix ↘
Fisher’s P-value0.8044
Information content12.12
Max PWM score13.43
Recommended cutoff7.43
Position frequency matrix (PFM)
A | 0.02 0.21 0.67 0.01 0.39 0.01 0.42 0.04 0.15 0.01 0.40 0.01 0.64 0.01 C | 0.11 0.01 0.12 0.38 0.29 0.01 0.40 0.03 0.71 0.01 0.02 0.01 0.01 0.35 G | 0.01 0.06 0.05 0.01 0.06 0.01 0.01 0.79 0.07 0.29 0.55 0.01 0.03 0.60 T | 0.86 0.72 0.16 0.61 0.27 0.97 0.18 0.14 0.06 0.70 0.03 0.97 0.33 0.04
Position count matrix (PCM)
A | 2 21 67 1 39 1 42 4 15 1 40 1 64 1 C | 11 1 12 38 28 1 40 3 71 1 2 1 1 35 G | 1 6 5 1 6 1 1 79 7 28 55 1 3 60 T | 86 72 16 61 27 97 18 14 6 70 3 97 33 4
Position weight matrix (PWM)
A | -2.77 -0.42 0.74 -3.47 0.20 -3.47 0.27 -2.08 -0.76 -3.47 0.22 -3.47 0.69 -3.47 C | -0.49 -2.89 -0.41 0.75 0.48 -2.89 0.80 -1.79 1.37 -2.89 -2.20 -2.89 -2.89 0.66 G | -2.89 -1.10 -1.28 -2.89 -1.10 -2.89 -2.89 1.48 -0.94 0.48 1.12 -2.89 -1.79 1.20 T | 0.99 0.81 -0.69 0.65 -0.17 1.11 -0.58 -0.83 -1.67 0.78 -2.37 1.11 0.03 -2.08
ECM22Macisaac et. alP = 1View matrix ↘
Fisher’s P-value1
Information content19.16
Max PWM score15
Recommended cutoff11.25
Position frequency matrix (PFM)
A | 0.012 0.012 0.012 0.012 0.012 0.964 0.012 0.964 0.964 0.012 0.012 C | 0.964 0.012 0.964 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.964 G | 0.012 0.012 0.012 0.964 0.012 0.012 0.012 0.012 0.012 0.964 0.012 T | 0.012 0.964 0.012 0.012 0.964 0.012 0.964 0.012 0.012 0.012 0.012
Position count matrix (PCM)
A | 1 1 1 1 1 96 1 96 96 1 1 C | 96 1 96 1 1 1 1 1 1 1 96 G | 1 1 1 96 1 1 1 1 1 96 1 T | 1 96 1 1 96 1 96 1 1 1 1
Position weight matrix (PWM)
A | -3.28 -3.28 -3.28 -3.28 -3.28 1.10 -3.28 1.10 1.10 -3.28 -3.28 C | 1.68 -2.71 1.68 -2.71 -2.71 -2.71 -2.71 -2.71 -2.71 -2.71 1.68 G | -2.71 -2.71 -2.71 1.68 -2.71 -2.71 -2.71 -2.71 -2.71 1.68 -2.71 T | -3.28 1.10 -3.28 -3.28 1.10 -3.28 1.10 -3.28 -3.28 -3.28 -3.28
ECM22Zhao and StormoP = 0.005716View matrix ↘
Fisher’s P-value0.005716
Information content5.939
Max PWM score7.04
Recommended cutoff3.96
Position frequency matrix (PFM)
A | 0.181 0.089 0.001 0.001 0.062 0.289 0.292 0.241 C | 0.316 0.260 0.870 0.997 0.098 0.194 0.216 0.267 G | 0.174 0.166 0.001 0.001 0.741 0.326 0.262 0.251 T | 0.329 0.484 0.128 0.001 0.098 0.190 0.230 0.241
Position count matrix (PCM)
A | 18 8 0 0 6 28 29 24 C | 31 26 87 99 9 19 21 26 G | 17 16 0 0 74 32 26 25 T | 32 48 12 0 9 19 23 24
Position weight matrix (PWM)
A | -0.57 -1.28 -5.77 -5.77 -1.64 -0.10 -0.09 -0.28 C | 0.56 0.37 1.58 1.71 -0.61 0.07 0.18 0.39 G | -0.03 -0.08 -5.19 -5.19 1.42 0.59 0.38 0.33 T | 0.03 0.41 -0.92 -5.77 -1.18 -0.52 -0.33 -0.28
03 / EXPERIMENTAL CONTEXT
Gene-level annotations and interactions.
Genes bound in ChIP-chip experiments 6 genes
YAL008W, YBR260C, YBR261C, YBR263W, YFR050C, YPL185W
Genes affected by TF deletion 69 genes
YDR432W, YDR188W, YLR056W, YIL111W, YKR038C, YNL017C, YGL012W, YDR098C, YIR030C, YNL143C, YMR314W, YLL059C, YMR072W, YLR100W, YOL053W, YJR101W, YEL023C, YKL055C, YLR101C, YMR227C, YOR072W, YPR148C, YLR164W, YIR037W, YBR296C, YJL222W, YIL096C, YLR228C, YMR030W, YFR048W, YNL094W, YPL063W, YMR272C, YMR146C, YMR119W-A, YOL153C, YER044C, YER100W, YLR165C, YMR325W, YER091C, YBR024W, YCR006C, YIL172C, YMR033W, YAR047C, YBR185C, YGL255W, YAL026C, YAL058C-A, YAR031W, YAL059W, YBR178W, YDL087C, YDR267C, YDR213W, YML014W, YDR182W, YGR085C, YHR046C, YHR107C, YMR154C, YNL203C, YOL132W, YBR151W, YBR089W, YDR121W, YGR024C, YGR267C