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DOT6

YER088C, PBF2

View at SGD ↗

Protein involved in rRNA and ribosome biogenesis; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; similar to Tod6p; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation

01 / RECOMMENDED MATRIX

Best-performing DNA-binding model.

RecommendedSource: Zhu et. al.
Fisher’s P-value0.0001403
Information content12.59
Max PWM score12.03
Recommended cutoff6.04
View and copy the recommended matrices ↘
Position frequency matrix (PFM)
A | 0.52 0.08 0.03 0.01 0.01 0.96 0.01 0.01 0.04 0.22 
C | 0.06 0.42 0.76 0.05 0.97 0.01 0.01 0.95 0.01 0.58 
G | 0.14 0.39 0.20 0.08 0.01 0.01 0.03 0.01 0.88 0.18 
T | 0.29 0.11 0.01 0.85 0.01 0.03 0.95 0.03 0.08 0.02 
Position count matrix (PCM)
A |  52   8   3   1   1  96   1   1   4  22 
C |   6  42  76   5  97   1   1  95   1  57 
G |  14  39  20   8   1   1   3   1  88  18 
T |  28  11   1  85   1   3  95   3   8   2 
Position weight matrix (PWM)
A |  0.49 -1.39 -2.37 -3.47 -3.47  1.10 -3.47 -3.47 -2.08 -0.37 
C | -1.10  0.85  1.44 -1.28  1.68 -2.89 -2.89  1.66 -2.89  1.17 
G | -0.25  0.77  0.11 -0.81 -2.89 -2.89 -1.79 -2.89  1.59  0.00 
T | -0.10 -1.07 -3.47  0.98 -3.47 -2.37  1.09 -2.37 -1.39 -2.77 
02 / COMPARATIVE BENCHMARKS

Alternative candidate matrices 3

Historical matrix candidates from the original ScerTF database. Expand a source to inspect its original logo, scores, and matrix values.

DOT6Badis et. al.P = 0.03383View matrix ↘
Sequence logo for DOT6
Fisher’s P-value0.03383
Information content7.268
Max PWM score5.58
Recommended cutoff5.58
Position frequency matrix (PFM)
A | 0.01 0.97 0.01 0.01 
C | 0.01 0.01 0.01 0.01 
G | 0.97 0.01 0.01 0.97 
T | 0.01 0.01 0.97 0.01 
Position count matrix (PCM)
A |   1  97   1   1 
C |   1   1   1   1 
G |  97   1   1  97 
T |   1   1  97   1 
Position weight matrix (PWM)
A | -3.47  1.11 -3.47 -3.47 
C | -2.89 -2.89 -2.89 -2.89 
G |  1.68 -2.89 -2.89  1.68 
T | -3.47 -3.47  1.11 -3.47 
DOT6Foat et. al.P = 1View matrix ↘
Sequence logo for DOT6
Fisher’s P-value1
Information content20.62
Max PWM score23.76
Recommended cutoff17.82
Position frequency matrix (PFM)
A | 0.02 0.24 0.01 0.01 0.01 0.16 0.18 0.01 0.18 0.08 0.18 0.25 0.13 0.06 0.01 0.32 0.10 0.01 0.05 0.01 0.36 0.21 0.24 
C | 0.43 0.42 0.62 0.02 0.97 0.62 0.32 0.15 0.29 0.17 0.32 0.01 0.02 0.31 0.20 0.19 0.14 0.01 0.83 0.95 0.13 0.37 0.06 
G | 0.50 0.26 0.26 0.96 0.01 0.20 0.34 0.33 0.05 0.06 0.40 0.32 0.61 0.13 0.77 0.01 0.38 0.97 0.12 0.02 0.50 0.27 0.60 
T | 0.05 0.09 0.11 0.01 0.01 0.02 0.15 0.50 0.47 0.68 0.10 0.43 0.24 0.50 0.02 0.49 0.38 0.01 0.01 0.02 0.01 0.15 0.10 
Position count matrix (PCM)
A |   2  24   1   1   1  16  18   1  18   8  18  25  13   6   1  32  10   1   5   1  36  21  24 
C |  43  42  62   2  97  62  32  15  28  17  32   1   2  31  20  19  14   1  83  95  13  37   6 
G |  50  26  26  96   1  20  34  33   5   6  40  32  61  13  77   1  38  97  12   2  50  27  60 
T |   5   9  11   1   1   2  15  50  47  68  10  43  24  50   2  49  38   1   1   2   1  15  10 
Position weight matrix (PWM)
A | -2.77 -0.29 -3.47 -3.47 -3.47 -0.69 -0.58 -3.47 -0.58 -1.39 -0.58 -0.25 -0.90 -1.67 -3.47  0.00 -1.16 -3.47 -1.86 -3.47  0.12 -0.42 -0.29 
C |  0.87  0.85  1.24 -2.20  1.68  1.24  0.58 -0.18  0.48 -0.06  0.58 -2.89 -2.20  0.54  0.11  0.05 -0.25 -2.89  1.53  1.66 -0.33  0.72 -1.10 
G |  1.02  0.37  0.37  1.67 -2.89  0.11  0.64  0.61 -1.28 -1.10  0.80  0.58  1.22 -0.33  1.45 -2.89  0.75  1.68 -0.41 -2.20  1.02  0.41  1.20 
T | -1.86 -1.27 -1.07 -3.47 -3.47 -2.77 -0.76  0.45  0.38  0.75 -1.16  0.30 -0.29  0.45 -2.77  0.43  0.17 -3.47 -3.47 -2.77 -3.47 -0.76 -1.16 
DOT6Zhao and StormoP = 0.0004195View matrix ↘
Sequence logo for DOT6
Fisher’s P-value0.0004195
Information content8.312
Max PWM score8.66
Recommended cutoff7.11
Position frequency matrix (PFM)
A | 0.160 0.099 0.003 0.924 0.001 0.001 0.164 0.209 
C | 0.394 0.198 0.976 0.003 0.002 0.927 0.105 0.446 
G | 0.336 0.267 0.004 0.012 0.046 0.007 0.543 0.224 
T | 0.111 0.436 0.018 0.061 0.951 0.065 0.188 0.122 
Position count matrix (PCM)
A |  16   9   0  92   0   0  16  20 
C |  39  19  97   0   0  92  10  44 
G |  33  26   0   1   4   0  54  22 
T |  11  43   1   6  95   6  18  12 
Position weight matrix (PWM)
A | -0.69 -1.17 -4.67  1.06 -5.77 -5.77 -0.67 -0.43 
C |  0.78  0.10  1.69 -4.09 -4.50  1.64 -0.54  0.91 
G |  0.62  0.39 -3.81 -2.71 -1.36 -3.25  1.10  0.22 
T | -1.06  0.31 -2.88 -1.66  1.09 -1.59 -0.53 -0.96 
03 / EXPERIMENTAL CONTEXT

Gene-level annotations and interactions.

Genes bound in ChIP-chip experiments 4 genes

YDL146W, YER044C-A, YFR007W, YMR056C

Genes affected by TF deletion 64 genes

YDR036C, YJR083C, YHR146W, YMR191W, YPL016W, YJR112W, YOL136C, YAR068W, YNL337W, YBR129C, YNL146W, YDR309C, YDR313C, YER029C, YKL206C, YOR229W, YGR134W, YMR023C, YNR066C, YLR099C, YML007W, YMR171C, YMR145C, YHR214W, YNL309W, YPL156C, YBR135W, YNL152W, YCL025C, YPR199C, YGL062W, YNL065W, YNR077C, YNL289W, YDR019C, YAL018C, YMR175W, YGR049W, YJR130C, YLL050C, YLR015W, YMR151W, YPR066W, YJL167W, YMR298W, YIR016W, YOL155C, YHR018C, YLR297W, YGR146C, YLR428C, YIL169C, YLR265C, YLR269C, YMR034C, YOR212W, YBR244W, YDL117W, YLR049C, YNL264C, YDR122W, YHR074W, YNR018W, YJR011C

Predicted TF–TF partners 3 genes

EDS1, STB3, TOD6

Explore 3 original interaction plots →