S.ScerTFYeast transcription factor database Aaron Spivak
← All factors / TF RECORD

CAD1

YDR423C, YAP2

View at SGD ↗

AP-1-like basic leucine zipper (bZIP) transcriptional activator involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA

01 / RECOMMENDED MATRIX

Best-performing DNA-binding model.

RecommendedSource: Aligned Matrix
Fisher’s P-value4.88e-27
Information content12.48
Max PWM score11.47
Recommended cutoff9.48
View and copy the recommended matrices ↘
Position frequency matrix (PFM)
A | 0.811 0.026 0.007 0.850 0.159 0.016 0.834 0.986 0.004 0.030 
C | 0.116 0.002 0.008 0.027 0.155 0.004 0.147 0.002 0.006 0.901 
G | 0.042 0.009 0.005 0.006 0.664 0.006 0.006 0.005 0.607 0.011 
T | 0.032 0.963 0.979 0.116 0.022 0.974 0.012 0.007 0.383 0.057
Position count matrix (PCM)
A |  81   2   0  85  15   1  83  98   0   3 
C |  11   0   0   2  15   0  14   0   0  90 
G |   4   0   0   0  66   0   0   0  60   1 
T |   3  96  97  11   2  97   1   0  38   5
Position weight matrix (PWM)
A |  0.93 -2.51 -3.82  0.98 -0.70 -3.00  0.96  1.13 -4.38 -2.37 
C | -0.44 -4.50 -3.11 -1.90 -0.15 -3.81 -0.20 -4.50 -3.40  1.61 
G | -1.46 -3.00 -3.58 -3.40  1.31 -3.40 -3.40 -3.58  1.22 -2.80 
T | -2.30  1.10  1.12 -1.01 -2.68  1.11 -3.28 -3.82  0.18 -1.73
02 / COMPARATIVE BENCHMARKS

Alternative candidate matrices 10

Historical matrix candidates from the original ScerTF database. Expand a source to inspect its original logo, scores, and matrix values.

CAD1_AFoat et. al.P = 1View matrix ↘
Sequence logo for CAD1_A
Fisher’s P-value1
Information content18.3
Max PWM score22.65
Recommended cutoff16.99
Position frequency matrix (PFM)
A | 0.07 0.05 0.40 0.83 0.01 0.01 0.24 0.50 0.25 0.47 0.01 0.35 0.28 0.13 0.14 0.10 0.12 0.15 0.42 0.70 0.34 0.03 0.01 0.87 0.28 0.29 0.28 
C | 0.52 0.18 0.08 0.01 0.01 0.97 0.13 0.01 0.63 0.22 0.39 0.01 0.37 0.64 0.30 0.09 0.37 0.06 0.24 0.09 0.11 0.01 0.01 0.11 0.21 0.11 0.15 
G | 0.29 0.38 0.19 0.01 0.97 0.01 0.25 0.09 0.10 0.25 0.38 0.04 0.01 0.21 0.40 0.08 0.46 0.55 0.02 0.01 0.18 0.95 0.08 0.01 0.27 0.30 0.51 
T | 0.13 0.40 0.33 0.15 0.01 0.01 0.38 0.41 0.01 0.05 0.23 0.60 0.35 0.03 0.16 0.73 0.05 0.24 0.32 0.20 0.36 0.01 0.89 0.01 0.24 0.30 0.06
Position count matrix (PCM)
A |   7   5  40  83   1   1  24  50  25  47   1  35  28  13  14  10  12  15  42  70  34   3   1  87  28  28  28 
C |  52  18   8   1   1  97  13   1  63  22  39   1  37  64  30   9  37   6  24   9  11   1   1  11  21  11  15 
G |  28  38  19   1  97   1  25   9  10  25  38   4   1  21  40   8  46  55   2   1  18  95   8   1  27  30  51 
T |  13  40  33  15   1   1  38  41   1   5  23  60  35   3  16  73   5  24  32  20  36   1  89   1  24  30   6
Position weight matrix (PWM)
A | -1.52 -1.86  0.22  0.95 -3.47 -3.47 -0.29  0.45 -0.25  0.38 -3.47  0.09 -0.13 -0.90 -0.83 -1.16 -0.98 -0.76  0.27  0.78  0.06 -2.37 -3.47  1.00 -0.13 -0.10 -0.13 
C |  1.06  0.00 -0.81 -2.89 -2.89  1.68 -0.33 -2.89  1.25  0.20  0.77 -2.89  0.72  1.27  0.51 -0.69  0.72 -1.10  0.29 -0.69 -0.49 -2.89 -2.89 -0.49  0.15 -0.49 -0.18 
G |  0.48  0.75  0.05 -2.89  1.68 -2.89  0.33 -0.69 -0.59  0.33  0.75 -1.50 -2.89  0.15  0.80 -0.81  0.94  1.12 -2.20 -2.89  0.00  1.66 -0.81 -2.89  0.41  0.51  1.04 
T | -0.90  0.22  0.03 -0.76 -3.47 -3.47  0.17  0.25 -3.47 -1.86 -0.33  0.63  0.09 -2.37 -0.69  0.82 -1.86 -0.29  0.00 -0.47  0.12 -3.47  1.02 -3.47 -0.29 -0.06 -1.67
Foat et. al.
CAD1_BFoat et. al.P = 4.38e-05View matrix ↘
Sequence logo for CAD1_B
Fisher’s P-value4.38e-05
Information content16.57
Max PWM score16.14
Recommended cutoff11.27
Position frequency matrix (PFM)
A | 0.03 0.31 0.01 0.03 0.97 0.01 0.03 0.15 0.03 0.97 0.12 0.13 0.01 
C | 0.09 0.01 0.03 0.44 0.01 0.89 0.01 0.01 0.01 0.01 0.52 0.66 0.91 
G | 0.37 0.68 0.88 0.01 0.01 0.07 0.95 0.01 0.60 0.01 0.34 0.19 0.01 
T | 0.50 0.01 0.08 0.53 0.01 0.03 0.01 0.83 0.36 0.01 0.02 0.02 0.07
Position count matrix (PCM)
A |   3  31   1   3  97   1   3  15   3  97  12  13   1 
C |   9   1   3  44   1  89   1   1   1   1  52  66  91 
G |  37  68  88   1   1   7  95   1  60   1  34  19   1 
T |  50   1   8  53   1   3   1  83  36   1   2   2   7
Position weight matrix (PWM)
A | -2.37 -0.03 -3.47 -2.37  1.11 -3.47 -2.37 -0.76 -2.37  1.11 -0.98 -0.90 -3.47 
C | -0.69 -2.89 -1.79  0.89 -2.89  1.60 -2.89 -2.89 -2.89 -2.89  1.06  1.30  1.62 
G |  0.72  1.33  1.59 -2.89 -2.89 -0.94  1.66 -2.89  1.20 -2.89  0.64  0.05 -2.89 
T |  0.45 -3.47 -1.39  0.50 -3.47 -2.37 -3.47  0.95  0.12 -3.47 -2.77 -2.77 -1.52
Foat et. al.
CAD1_CFoat et. al.P = 0.0001573View matrix ↘
Sequence logo for CAD1_C
Fisher’s P-value0.0001573
Information content18.92
Max PWM score17.61
Recommended cutoff10.13
Position frequency matrix (PFM)
A | 0.75 0.08 0.10 0.97 0.01 0.01 0.01 0.23 0.48 0.97 0.01 0.01 0.01 0.62 0.21 
C | 0.02 0.44 0.83 0.01 0.97 0.95 0.01 0.01 0.02 0.01 0.86 0.97 0.76 0.01 0.29 
G | 0.22 0.03 0.07 0.01 0.01 0.01 0.55 0.75 0.08 0.01 0.01 0.01 0.01 0.01 0.01 
T | 0.01 0.45 0.01 0.01 0.01 0.03 0.44 0.01 0.43 0.01 0.12 0.01 0.23 0.36 0.50
Position count matrix (PCM)
A |  75   8  10  97   1   1   1  23  48  97   1   1   1  62  21 
C |   2  44  83   1  97  95   1   1   2   1  86  97  76   1  28 
G |  22   3   7   1   1   1  55  75   8   1   1   1   1   1   1 
T |   1  45   1   1   1   3  44   1  43   1  12   1  23  36  50
Position weight matrix (PWM)
A |  0.85 -1.39 -1.16  1.11 -3.47 -3.47 -3.47 -0.33  0.41  1.11 -3.47 -3.47 -3.47  0.66 -0.42 
C | -2.20  0.89  1.53 -2.89  1.68  1.66 -2.89 -2.89 -2.20 -2.89  1.56  1.68  1.44 -2.89  0.48 
G |  0.20 -1.79 -0.94 -2.89 -2.89 -2.89  1.12  1.43 -0.81 -2.89 -2.89 -2.89 -2.89 -2.89 -2.89 
T | -3.47  0.34 -3.47 -3.47 -3.47 -2.37  0.32 -3.47  0.30 -3.47 -0.98 -3.47 -0.33  0.12  0.45
Foat et. al.
CAD1_AFordyce et. al.P = 0.3325View matrix ↘
Fisher’s P-value0.3325
Information content8.972
Max PWM score8.31
Recommended cutoff6.96
Position frequency matrix (PFM)
A | 0.01 0.09 0.01 0.91 0.92 0.01 0.01 0.57 
C | 0.32 0.01 0.01 0.04 0.06 0.10 0.01 0.27 
G | 0.44 0.89 0.01 0.04 0.01 0.08 0.04 0.15 
T | 0.24 0.01 0.97 0.01 0.01 0.82 0.94 0.01
Position count matrix (PCM)
A |   1   9   1  91  92   1   1  56 
C |  32   1   1   4   6  10   1  27 
G |  44  89   1   4   1   8   4  15 
T |  24   1  97   1   1  82  94   1
Position weight matrix (PWM)
A | -3.47 -1.27 -3.47  1.05  1.06 -3.47 -3.47  0.58 
C |  0.58 -2.89 -2.89 -1.50 -1.10 -0.59 -2.89  0.41 
G |  0.89  1.60 -2.89 -1.50 -2.89 -0.81 -1.50 -0.18 
T | -0.29 -3.47  1.11 -3.47 -3.47  0.94  1.08 -3.47
Fordyce et. al.
CAD1_BFordyce et. al.P = 0.8523View matrix ↘
Fisher’s P-value0.8523
Information content8.774
Max PWM score8.22
Recommended cutoff8.01
Position frequency matrix (PFM)
A | 0.58 0.01 0.14 0.01 0.90 0.93 0.01 0.01 
C | 0.28 0.35 0.01 0.01 0.04 0.05 0.10 0.02 
G | 0.13 0.43 0.84 0.01 0.05 0.01 0.07 0.04 
T | 0.01 0.22 0.01 0.97 0.01 0.01 0.82 0.93
Position count matrix (PCM)
A |  57   1  14   1  90  93   1   1 
C |  28  35   1   1   4   5  10   2 
G |  13  43  84   1   5   1   7   4 
T |   1  22   1  97   1   1  82  93
Position weight matrix (PWM)
A |  0.59 -3.47 -0.83 -3.47  1.03  1.07 -3.47 -3.47 
C |  0.44  0.66 -2.89 -2.89 -1.50 -1.28 -0.59 -2.20 
G | -0.33  0.87  1.54 -2.89 -1.28 -2.89 -0.94 -1.50 
T | -3.47 -0.37 -3.47  1.11 -3.47 -3.47  0.94  1.07
Fordyce et. al.
CAD1_CFordyce et. al.P = 1View matrix ↘
Fisher’s P-value1
Information content9.635
Max PWM score8.83
Recommended cutoff6.62
Position frequency matrix (PFM)
A | 0.02 0.01 0.97 0.02 0.12 0.01 0.80 0.97 
C | 0.10 0.01 0.01 0.47 0.01 0.01 0.10 0.01 
G | 0.01 0.01 0.01 0.24 0.86 0.06 0.09 0.01 
T | 0.87 0.97 0.01 0.27 0.01 0.92 0.01 0.01
Position count matrix (PCM)
A |   2   1  97   2  12   1  80  97 
C |  10   1   1  47   1   1  10   1 
G |   1   1   1  24  86   6   9   1 
T |  87  97   1  27   1  92   1   1
Position weight matrix (PWM)
A | -2.77 -3.47  1.11 -2.77 -0.98 -3.47  0.92  1.11 
C | -0.59 -2.89 -2.89  0.96 -2.89 -2.89 -0.59 -2.89 
G | -2.89 -2.89 -2.89  0.29  1.56 -1.10 -0.69 -2.89 
T |  1.00  1.11 -3.47 -0.17 -3.47  1.06 -3.47 -3.47
Fordyce et. al.
CAD1Harbison et. al.P = 1.70e-26View matrix ↘
Sequence logo for CAD1
Fisher’s P-value1.70e-26
Information content11.57
Max PWM score11.08
Recommended cutoff9.93
Position frequency matrix (PFM)
A | 0.710 0.008 0.014 0.826 0.054 0.031 0.765 0.974 0.007 0.060 
C | 0.188 0.004 0.016 0.009 0.218 0.007 0.199 0.004 0.011 0.847 
G | 0.040 0.017 0.009 0.012 0.686 0.011 0.012 0.009 0.576 0.022 
T | 0.062 0.971 0.962 0.153 0.042 0.952 0.024 0.013 0.407 0.071
Position count matrix (PCM)
A |  71   0   1  82   5   3  76  97   0   6 
C |  18   0   1   0  21   0  19   0   1  84 
G |   4   1   0   1  68   1   1   0  57   2 
T |   6  97  96  15   4  95   2   1  40   7
Position weight matrix (PWM)
A |  0.80 -3.69 -3.13  0.95 -1.78 -2.33  0.87  1.11 -3.82 -1.67 
C |  0.04 -3.81 -2.42 -3.00  0.19 -3.25  0.10 -3.81 -2.80  1.55 
G | -1.50 -2.36 -3.00 -2.71  1.34 -2.80 -2.71 -3.00  1.16 -2.10 
T | -1.64  1.11  1.10 -0.74 -2.03  1.09 -2.59 -3.20  0.24 -1.51
Harbison et. al.
CAD1Macisaac et. alP = 3.62e-26View matrix ↘
Sequence logo for CAD1
Fisher’s P-value3.62e-26
Information content10.79
Max PWM score11.1
Recommended cutoff8.48
Position frequency matrix (PFM)
A | 0.113 0.303 0.027 0.044 0.881 0.053 0.113 0.939 0.963 0.018 
C | 0.001 0.584 0.018 0.001 0.056 0.730 0.001 0.030 0.009 0.060 
G | 0.777 0.027 0.009 0.223 0.001 0.078 0.047 0.001 0.001 0.049 
T | 0.109 0.086 0.946 0.732 0.062 0.139 0.839 0.030 0.027 0.873
Position count matrix (PCM)
A |  11  30   2   4  88   5  11  93  96   1 
C |   0  58   1   0   5  73   0   3   0   6 
G |  77   2   0  22   0   7   4   0   0   4 
T |  10   8  94  73   6  13  83   3   2  87
Position weight matrix (PWM)
A | -1.04 -0.05 -2.47 -1.98  1.01 -1.80 -1.04  1.08  1.10 -2.88 
C | -5.19  1.18 -2.30 -5.19 -1.17  1.40 -5.19 -1.79 -3.00 -1.10 
G |  1.46 -1.90 -3.00  0.21 -5.19 -0.84 -1.34 -5.19 -5.19 -1.30 
T | -1.08 -1.31  1.08  0.83 -1.64 -0.83  0.96 -2.37 -2.47  1.00
Macisaac et. al
CAD1Morozov et. al.P = 2.72e-26View matrix ↘
Sequence logo for CAD1
Fisher’s P-value2.72e-26
Information content11.82
Max PWM score11.36
Recommended cutoff9.04
Position frequency matrix (PFM)
A | 0.022 0.321 0.009 0.010 0.955 0.055 0.186 0.923 0.941 0.017 
C | 0.013 0.601 0.014 0.009 0.023 0.849 0.042 0.006 0.036 0.080 
G | 0.884 0.064 0.004 0.177 0.009 0.051 0.027 0.054 0.010 0.106 
T | 0.081 0.014 0.973 0.805 0.012 0.045 0.744 0.016 0.014 0.797
Position count matrix (PCM)
A |   2  32   0   1  95   5  18  92  94   1 
C |   1  60   1   0   2  84   4   0   3   8 
G |  88   6   0  17   0   5   2   5   1  10 
T |   8   1  97  80   1   4  74   1   1  79
Position weight matrix (PWM)
A | -2.68  0.00 -3.57 -3.47  1.09 -1.76 -0.54  1.06  1.08 -2.94 
C | -2.63  1.21 -2.55 -3.00 -2.06  1.55 -1.46 -3.40 -1.61 -0.81 
G |  1.59 -1.03 -3.81 -0.02 -3.00 -1.26 -1.90 -1.20 -2.89 -0.53 
T | -1.37 -3.13  1.11  0.92 -3.28 -1.96  0.84 -3.00 -3.13  0.91
Morozov et. al.
CAD1Pachkov et alP = 9.20e-25View matrix ↘
Sequence logo for CAD1
Fisher’s P-value9.20e-25
Information content14.07
Max PWM score11.82
Recommended cutoff9.36
Position frequency matrix (PFM)
A | 0.912 0.044 0.001 0.875 0.264 0.001 0.904 1.000 0.001 0.001 
C | 0.044 0.001 0.001 0.045 0.093 0.001 0.096 0.001 0.001 0.956 
G | 0.043 0.001 0.001 0.001 0.642 0.001 0.001 0.001 0.640 0.001 
T | 0.001 0.956 1.000 0.080 0.001 1.000 0.001 0.001 0.360 0.044
Position count matrix (PCM)
A |  91   4   0  87  26   0  90 100   0   0 
C |   4   0   0   4   9   0   9   0   0  95 
G |   4   0   0   0  64   0   0   0  64   0 
T |   0  95 100   8   0 100   0   0  36   4
Position weight matrix (PWM)
A |  1.05 -1.98 -5.77  1.01 -0.19 -5.77  1.04  1.14 -5.77 -5.77 
C | -1.41 -5.19 -5.19 -1.39 -0.66 -5.19 -0.63 -5.19 -5.19  1.67 
G | -1.43 -5.19 -5.19 -5.19  1.27 -5.19 -5.19 -5.19  1.27 -5.19 
T | -5.77  1.09  1.14 -1.39 -5.77  1.14 -5.77 -5.77  0.12 -1.98
Pachkov et al
03 / EXPERIMENTAL CONTEXT

Gene-level annotations and interactions.

Genes bound in ChIP-chip experiments 68 genes

YAL058W, YBL008W, YBL034C, YBR046C, YBR047W, YBR057C, YBR280C, YCR037C, YDL104C, YDL239C, YDR036C, YDR037W, YDR132C, YDR135C, YDR137W, YDR543C, YEL044W, YEL045C, YEL046C, YER141W, YGL115W, YGL157W, YGR167W, YGR233C, YGR234W, YHL039W, YHL040C, YHR008C, YHR048W, YHR053C, YHR055C, YHR077C, YHR078W, YHR091C, YHR133C, YHR134W, YJL100W, YJL101C, YJR044C, YKL039W, YKL040C, YKL086W, YKL087C, YKL101W, YKL102C, YKL103C, YKL154W, YKL155C, YKR052C, YKR071C, YLL002W, YLL060C, YLL065W, YLR108C, YLR109W, YLR456W, YML116W, YML133C, YMR038C, YNL134C, YNL337W, YOL077W-A, YOL078W, YOL080C, YOL119C, YOR173W, YPL283C, YPR048W

Genes affected by TF deletion 105 genes

YJR048W, YMR192W, YOR377W, YBL087C, YOR192C-B, YOR258W, YEL017C-A, YHR145C, YLR089C, YPL016W, YOL104C, YLR152C, YLR184W, YMR258C, YOR133W, YOR165W, YPL084W, YGR064W, YMR102C, YCL020W, YDR281C, YGR183C, YML022W, YBR012C, YCR050C, YCL065W, YDR410C, YHR001W-A, YAR010C, YHR152W, YLR410W-B, YOR043W, YOR075W, YPL060W, YCR093W, YCL058C, YJR027W, YNR066C, YJR148W, YGR161C, YGR161W-B, YLR035C-A, YLR099C, YHR214C-B, YIL060W, YJL191W, YMR291W, YPL156C, YDL040C, YLR345W, YMR108W, YMR110C, YOR356W, YPR055W, YDL231C, YHR214C-C, YCR024C-A, YER129W, YGR294W, YIL100W, YBR235W, YGR164W, YLR110C, YBL101W-A, YDR417C, YGL188C, YOL059W, YEL060C, YKL120W, YKL030W, YPR002W, YDR298C, YKL221W, YOL119C, YPR035W, YHR136C, YJL143W, YBL107W-A, YCR031C, YFL002W-B, YER138W-A, YIL133C, YIL103W, YLR300W, YPL228W, YDR210W-A, YDR210W-C, YDR213W, YHR135C, YJL076W, YMR211W, YPL075W, YPR158W-B, YDL023C, YOL103W-A, YOR343C-B, YIL011W, YKL192C, YDL022W, YLR395C, YMR123W, YPR043W, YGR209C, YIL069C, YML081C-A

Genes supported by both experiments 1 genes

YOL119C