← All factors / TF RECORD

ARO80

YDR421W

View at SGD ↗

Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids

01 / RECOMMENDED MATRIX

Best-performing DNA-binding model.

RecommendedSource: Morozov et. al.
Fisher’s P-value2.78e-09
Information content9.766
Max PWM score11.98
Recommended cutoff11.42
View and copy the recommended matrices ↘
Position frequency matrix (PFM)
A | 0.052 0.091 0.018 0.243 0.373 0.569 0.198 0.085 0.276 0.212 0.053 0.026 0.076 
C | 0.827 0.044 0.062 0.223 0.180 0.137 0.146 0.339 0.234 0.028 0.877 0.151 0.066 
G | 0.058 0.833 0.798 0.100 0.075 0.170 0.188 0.187 0.247 0.208 0.035 0.747 0.834 
T | 0.063 0.032 0.123 0.434 0.372 0.124 0.468 0.388 0.244 0.552 0.036 0.075 0.024 
Position count matrix (PCM)
A |   5   9   1  24  37  56  19   8  27  21   5   2   7 
C |  82   4   6  22  18  13  14  33  23   2  87  15   6 
G |   5  83  79  10   7  17  18  18  24  20   3  74  83 
T |   6   3  12  43  37  12  46  38  24  55   3   7   2 
Position weight matrix (PWM)
A | -1.82 -1.26 -2.88 -0.28  0.15  0.58 -0.48 -1.33 -0.15 -0.41 -1.80 -2.51 -1.44 
C |  1.52 -1.41 -1.07  0.21  0.00 -0.27 -0.21  0.63  0.26 -1.86  1.58 -0.18 -1.00 
G | -1.13  1.53  1.49 -0.59 -0.88 -0.06  0.04  0.04  0.32  0.14 -1.64  1.42  1.53 
T | -1.63 -2.30 -0.96  0.30  0.15 -0.95  0.38  0.19 -0.27  0.55 -2.18 -1.45 -2.59 
02 / COMPARATIVE BENCHMARKS

Alternative candidate matrices 5

Historical matrix candidates from the original ScerTF database. Expand a source to inspect its original logo, scores, and matrix values.

ARO80_AFoat et. al.P = 0.01844View matrix ↘
Sequence logo for ARO80_A
Fisher’s P-value0.01844
Information content13.76
Max PWM score13.63
Recommended cutoff12.7
Position frequency matrix (PFM)
A | 0.01 0.03 0.21 0.01 0.01 0.03 0.03 0.93 0.24 0.06 0.11 0.01 
C | 0.38 0.13 0.68 0.01 0.01 0.01 0.01 0.01 0.44 0.05 0.16 0.01 
G | 0.18 0.15 0.01 0.96 0.97 0.95 0.01 0.01 0.27 0.75 0.32 0.34 
T | 0.43 0.69 0.10 0.02 0.01 0.01 0.95 0.05 0.06 0.13 0.41 0.65 
Position count matrix (PCM)
A |   1   3  21   1   1   3   3  93  24   6  11   1 
C |  38  13  68   1   1   1   1   1  44   5  16   1 
G |  18  15   1  96  97  95   1   1  27  75  32  34 
T |  43  69  10   2   1   1  95   5   6  13  41  65 
Position weight matrix (PWM)
A | -3.47 -2.37 -0.42 -3.47 -3.47 -2.37 -2.37  1.07 -0.29 -1.67 -1.07 -3.47 
C |  0.75 -0.33  1.33 -2.89 -2.89 -2.89 -2.89 -2.89  0.89 -1.28 -0.12 -2.89 
G |  0.00 -0.18 -2.89  1.67  1.68  1.66 -2.89 -2.89  0.41  1.43  0.58  0.64 
T |  0.30  0.77 -1.16 -2.77 -3.47 -3.47  1.09 -1.86 -1.67 -0.90  0.25  0.71 
ARO80_BFoat et. al.P = 2.13e-05View matrix ↘
Sequence logo for ARO80_B
Fisher’s P-value2.13e-05
Information content18.88
Max PWM score19.22
Recommended cutoff9.91
Position frequency matrix (PFM)
A | 0.13 0.39 0.90 0.01 0.01 0.06 0.56 0.04 0.03 0.66 0.42 0.37 0.01 0.01 0.96 0.01 0.12 0.07 0.11 
C | 0.33 0.41 0.08 0.85 0.97 0.06 0.10 0.04 0.46 0.02 0.47 0.17 0.57 0.97 0.01 0.97 0.22 0.11 0.49 
G | 0.01 0.19 0.01 0.13 0.01 0.01 0.34 0.23 0.08 0.02 0.01 0.33 0.03 0.01 0.02 0.01 0.01 0.32 0.40 
T | 0.53 0.01 0.01 0.01 0.01 0.86 0.01 0.69 0.43 0.30 0.10 0.13 0.40 0.01 0.01 0.01 0.65 0.51 0.01 
Position count matrix (PCM)
A |  13  39  90   1   1   6  56   4   3  66  42  37   1   1  96   1  12   7  11 
C |  33  41   8  85  97   6  10   4  46   2  47  17  56  97   1  97  22  11  49 
G |   1  19   1  13   1   1  34  23   8   2   1  33   3   1   2   1   1  32  40 
T |  53   1   1   1   1  86   1  69  43  30  10  13  40   1   1   1  65  51   1 
Position weight matrix (PWM)
A | -0.90  0.20  1.03 -3.47 -3.47 -1.67  0.56 -2.08 -2.37  0.72  0.27  0.15 -3.47 -3.47  1.10 -3.47 -0.98 -1.52 -1.07 
C |  0.61  0.82 -0.81  1.55  1.68 -1.10 -0.59 -1.50  0.94 -2.20  0.96 -0.06  1.15  1.68 -2.89  1.68  0.20 -0.49  1.00 
G | -2.89  0.05 -2.89 -0.33 -2.89 -2.89  0.64  0.25 -0.81 -2.20 -2.89  0.61 -1.79 -2.89 -2.20 -2.89 -2.89  0.58  0.80 
T |  0.50 -3.47 -3.47 -3.47 -3.47  0.99 -3.47  0.77  0.30 -0.06 -1.16 -0.90  0.22 -3.47 -3.47 -3.47  0.71  0.47 -3.47 
ARO80Macisaac et. alP = 3.59e-05View matrix ↘
Sequence logo for ARO80
Fisher’s P-value3.59e-05
Information content34.42
Max PWM score28.12
Recommended cutoff20.28
Position frequency matrix (PFM)
A | 0.143 0.001 0.001 0.286 0.001 0.428 0.429 0.001 0.428 0.428 0.001 0.001 0.001 0.428 0.143 0.855 0.143 0.001 0.001 0.143 0.001 0.001 0.001 
C | 0.855 0.997 0.001 0.143 0.143 0.001 0.143 0.001 0.001 0.143 0.997 0.997 0.001 0.570 0.286 0.001 0.001 0.001 0.001 0.001 0.997 0.997 0.001 
G | 0.001 0.001 0.997 0.143 0.713 0.285 0.286 0.001 0.001 0.428 0.001 0.001 0.997 0.001 0.570 0.001 0.286 0.001 0.001 0.855 0.001 0.001 0.997 
T | 0.001 0.001 0.001 0.429 0.143 0.285 0.143 0.997 0.570 0.001 0.001 0.001 0.001 0.001 0.001 0.143 0.570 0.997 0.997 0.001 0.001 0.001 0.001 
Position count matrix (PCM)
A |  14   0   0  28   0  42  42   0  42  42   0   0   0  42  14  85  14   0   0  14   0   0   0 
C |  85  99   0  14  14   0  14   0   0  14  99  99   0  56  28   0   0   0   0   0  99  99   0 
G |   0   0  99  14  71  28  28   0   0  42   0   0  99   0  56   0  28   0   0  85   0   0  99 
T |   0   0   0  42  14  28  14  99  56   0   0   0   0   0   0  14  56  99  99   0   0   0   0 
Position weight matrix (PWM)
A | -0.81 -5.77 -5.77 -0.11 -5.77  0.29  0.29 -5.77  0.29  0.29 -5.77 -5.77 -5.77  0.29 -0.81  0.98 -0.81 -5.77 -5.77 -0.81 -5.77 -5.77 -5.77 
C |  1.56  1.71 -5.19 -0.23 -0.23 -5.19 -0.23 -5.19 -5.19 -0.23  1.71  1.71 -5.19  1.15  0.46 -5.19 -5.19 -5.19 -5.19 -5.19  1.71  1.71 -5.19 
G | -5.19 -5.19  1.71 -0.23  1.38  0.46  0.46 -5.19 -5.19  0.87 -5.19 -5.19  1.71 -5.19  1.15 -5.19  0.46 -5.19 -5.19  1.56 -5.19 -5.19  1.71 
T | -5.77 -5.77 -5.77  0.29 -0.81 -0.12 -0.81  1.14  0.58 -5.77 -5.77 -5.77 -5.77 -5.77 -5.77 -0.81  0.58  1.14  1.14 -5.77 -5.77 -5.77 -5.77 
ARO80Zhu et. al.P = 0.004563View matrix ↘
Sequence logo for ARO80
Fisher’s P-value0.004563
Information content10.21
Max PWM score9.47
Recommended cutoff7.97
Position frequency matrix (PFM)
A | 0.04 0.01 0.01 0.01 0.01 0.02 0.66 0.69 
C | 0.74 0.23 0.97 0.02 0.01 0.36 0.01 0.07 
G | 0.03 0.01 0.01 0.96 0.97 0.30 0.01 0.06 
T | 0.19 0.75 0.01 0.01 0.01 0.33 0.32 0.18 
Position count matrix (PCM)
A |   4   1   1   1   1   2  66  69 
C |  74  23  97   2   1  36   1   7 
G |   3   1   1  96  97  30   1   6 
T |  19  75   1   1   1  33  32  18 
Position weight matrix (PWM)
A | -2.08 -3.47 -3.47 -3.47 -3.47 -2.77  0.72  0.77 
C |  1.41  0.25  1.68 -2.20 -2.89  0.69 -2.89 -0.94 
G | -1.79 -2.89 -2.89  1.67  1.68  0.51 -2.89 -1.10 
T | -0.52  0.85 -3.47 -3.47 -3.47  0.03  0.00 -0.58 
ARO80Zhao and StormoP = 0.003804View matrix ↘
Sequence logo for ARO80
Fisher’s P-value0.003804
Information content7.31
Max PWM score6.95
Recommended cutoff6.65
Position frequency matrix (PFM)
A | 0.221 0.174 0.001 0.001 0.001 0.206 0.495 0.355 
C | 0.314 0.192 0.990 0.065 0.007 0.281 0.090 0.189 
G | 0.202 0.190 0.008 0.933 0.991 0.284 0.130 0.197 
T | 0.262 0.444 0.001 0.001 0.001 0.230 0.285 0.260 
Position count matrix (PCM)
A |  22  17   0   0   0  20  49  35 
C |  31  19  99   6   0  28   9  18 
G |  20  19   0  93  99  28  13  19 
T |  26  44   0   0   0  23  28  26 
Position weight matrix (PWM)
A | -0.37 -0.61 -5.77 -5.77 -5.77 -0.44  0.44  0.10 
C |  0.56  0.06  1.70 -1.02 -3.25  0.45 -0.69  0.05 
G |  0.12  0.05 -3.11  1.65  1.71  0.46 -0.33  0.09 
T | -0.20  0.33 -5.77 -5.77 -5.77 -0.33 -0.12 -0.21 
03 / EXPERIMENTAL CONTEXT

Gene-level annotations and interactions.

Genes bound in ChIP-chip experiments 91 genes

YBR012W-A, YBR012W-B, YBR099C, YBR152W, YBR160W, YCL065W, YCL066W, YCL067C, YCL074W, YCR018C-A, YCR019W, YCR039C, YCR040W, YCR041W, YDL091C, YDR048C, YDR183W, YDR184C, YDR290W, YDR291W, YDR370C, YDR371W, YDR375C, YDR376W, YDR377W, YDR378C, YDR379W, YDR380W, YDR381W, YDR382W, YDR421W, YDR468C, YDR469W, YDR523C, YER061C, YFL059W, YFL060C, YGR053C, YGR054W, YGR166W, YGR244C, YHR132C, YHR133C, YHR134W, YHR135C, YHR136C, YHR137W, YHR138C, YHR139C, YHR139C-A, YHR140W, YHR141C, YHR142W, YHR143W, YJL008C, YJR001W, YKL051W, YKL052C, YKL072W, YKR059W, YKR060W, YLR082C, YMR194W, YMR283C, YNL012W, YNL013C, YNL117W, YNL118C, YNL122C, YNL123W, YNL124W, YNL125C, YNL126W, YNL337W, YNR006W, YOL001W, YOL002C, YOL116W, YOR005C, YOR110W, YOR205C, YOR206W, YOR218C, YOR273C, YOR274W, YPL018W, YPL019C, YPL251W, YPL253C, YPR155C, YPR162C

Genes affected by TF deletion 140 genes

YCR040W, YER178W, YGR280C, YIL082W-A, YJR020W, YOR225W, YOR257W, YDL131W, YFR032C-A, YGL009C, YHR174W, YBR029C, YBR031W, YER146W, YMR044W, YOR252W, YOR226C, YCR097W-A, YHR143W-A, YJL052W, YLR405W, YNL244C, YDR096W, YGR063C, YHR053C, YNL147W, YNL149C, YOR287C, YOR351C, YPR020W, YPL187W, YGL075C, YHR208W, YKL172W, YOR103C, YBR091C, YDR461W, YGR064W, YHR021C, YNL146W, YOL077W-A, YNL280C, YCL018W, YDR281C, YIL015W, YLR185W, YML055W, YCL065W, YDR378C, YLR287C-A, YNL030W, YPL183W-A, YDL106C, YHR123W, YNL279W, YOR045W, YBR011C, YCR045C, YJR148W, YBR162W-A, YER001W, YEL021W, YLR348C, YOL144W, YOL086C, YOR357C, YGR192C, YKL209C, YKL178C, YLR343W, YLR349W, YNL150W, YOL143C, YOR221C, YBR262C, YIL027C, YKL177W, YMR323W, YHR010W, YLR262C-A, YLR234W, YOR239W, YGR140W, YLR040C, YLR420W, YNL259C, YOR393W, YCL066W, YHR005C-A, YIL127C, YOR210W, YDL081C, YKL120W, YLR041W, YLR043C, YOR020C, YCR097W, YFL026W, YGR015C, YHR072W-A, YLR388W, YOL126C, YPR062W, YDR322C-A, YGL089C, YBR145W, YFL023W, YNL162W, YPL281C, YBR268W, YJR004C, YKL216W, YMR303C, YNR044W, YDR056C, YLR303W, YAL033W, YER019C-A, YGL031C, YGR148C, YHR141C, YJL141C, YCR028C-A, YDR421W, YLR302C, YNL070W, YGL032C, YGR114C, YLR051C, YLR421C, YBR118W, YGR025W, YJR135W-A, YOL132W, YDL184C, YJR009C, YKL164C, YKL163W, YML081C-A, YOR182C

Genes supported by both experiments 6 genes

YCL065W, YCL066W, YCR040W, YDR378C, YDR421W, YHR141C