S.ScerTFYeast transcription factor database Aaron Spivak
← All factors / TF RECORD

ACE2

YLR131C

View at SGD ↗

Transcription factor that activates expression of early G1-specific genes, localizes to daughter cell nuclei after cytokinesis and delays G1 progression in daughters, localization is regulated by phosphorylation; potential Cdc28p substrate

01 / RECOMMENDED MATRIX

Best-performing DNA-binding model.

RecommendedSource: Macisaac et. al
Fisher’s P-value2.04e-10
Information content7.209
Max PWM score8.38
Recommended cutoff6.34
View and copy the recommended matrices ↘
Position frequency matrix (PFM)
A | 0.743 0.731 0.001 0.029 0.548 0.274 0.112 0.601 
C | 0.124 0.032 0.804 0.832 0.361 0.030 0.524 0.339 
G | 0.132 0.199 0.027 0.001 0.017 0.646 0.066 0.017 
T | 0.001 0.038 0.168 0.138 0.074 0.050 0.298 0.043
Position count matrix (PCM)
A |  74  73   0   2  54  27  11  60 
C |  12   3  80  83  36   3  52  33 
G |  13  19   2   0   1  64   6   1 
T |   0   3  16  13   7   5  29   4
Position weight matrix (PWM)
A |  0.84  0.83 -5.77 -2.40  0.54 -0.16 -1.05  0.63 
C | -0.37 -1.73  1.50  1.53  0.70 -1.79  1.07  0.63 
G | -0.31  0.10 -1.90 -5.19 -2.36  1.28 -1.00 -2.36 
T | -5.77 -2.13 -0.64 -0.84 -1.46 -1.86 -0.07 -2.01
02 / COMPARATIVE BENCHMARKS

Alternative candidate matrices 7

Historical matrix candidates from the original ScerTF database. Expand a source to inspect its original logo, scores, and matrix values.

ACE2Badis et. al.P = 3.16e-08View matrix ↘
Sequence logo for ACE2
Fisher’s P-value3.16e-08
Information content9.724
Max PWM score7.68
Recommended cutoff6.08
Position frequency matrix (PFM)
A | 0.01 0.01 0.88 0.01 0.01 
C | 0.92 0.97 0.10 0.01 0.97 
G | 0.06 0.01 0.01 0.97 0.01 
T | 0.01 0.01 0.01 0.01 0.01
Position count matrix (PCM)
A |   1   1  88   1   1 
C |  92  97  10   1  97 
G |   6   1   1  97   1 
T |   1   1   1   1   1
Position weight matrix (PWM)
A | -3.47 -3.47  1.01 -3.47 -3.47 
C |  1.63  1.68 -0.59 -2.89  1.68 
G | -1.10 -2.89 -2.89  1.68 -2.89 
T | -3.47 -3.47 -3.47 -3.47 -3.47
Badis et. al.
ACE2Foat et. al.P = 4.31e-13View matrix ↘
Sequence logo for ACE2
Fisher’s P-value4.31e-13
Information content16.71
Max PWM score14.82
Recommended cutoff11.03
Position frequency matrix (PFM)
A | 0.97 0.01 0.91 0.01 0.12 0.01 0.95 0.53 0.97 0.01 0.02 0.01 
C | 0.01 0.71 0.01 0.97 0.01 0.97 0.01 0.30 0.01 0.94 0.02 0.62 
G | 0.01 0.27 0.07 0.01 0.06 0.01 0.01 0.02 0.01 0.01 0.73 0.01 
T | 0.01 0.01 0.01 0.01 0.81 0.01 0.04 0.15 0.01 0.04 0.23 0.37
Position count matrix (PCM)
A |  97   1  91   1  12   1  95  53  97   1   2   1 
C |   1  71   1  97   1  97   1  30   1  94   2  62 
G |   1  27   7   1   6   1   1   2   1   1  73   1 
T |   1   1   1   1  81   1   4  15   1   4  23  37
Position weight matrix (PWM)
A |  1.11 -3.47  1.05 -3.47 -0.98 -3.47  1.09  0.50  1.11 -3.47 -2.77 -3.47 
C | -2.89  1.37 -2.89  1.68 -2.89  1.68 -2.89  0.51 -2.89  1.65 -2.20  1.24 
G | -2.89  0.41 -0.94 -2.89 -1.10 -2.89 -2.89 -2.20 -2.89 -2.89  1.40 -2.89 
T | -3.47 -3.47 -3.47 -3.47  0.93 -3.47 -2.08 -0.76 -3.47 -2.08 -0.33  0.15
Foat et. al.
ACE2_AFordyce et. al.P = 3.13e-09View matrix ↘
Fisher’s P-value3.13e-09
Information content9.747
Max PWM score9.11
Recommended cutoff5.9
Position frequency matrix (PFM)
A | 0.02 0.01 0.01 0.04 0.01 0.01 0.17 0.22 
C | 0.01 0.96 0.01 0.01 0.06 0.24 0.42 0.20 
G | 0.96 0.02 0.08 0.90 0.87 0.26 0.09 0.16 
T | 0.01 0.01 0.90 0.05 0.06 0.49 0.32 0.42
Position count matrix (PCM)
A |   2   1   1   4   1   1  17  22 
C |   1  96   1   1   6  24  42  20 
G |  96   2   8  90  87  26   9  16 
T |   1   1  90   5   6  49  32  42
Position weight matrix (PWM)
A | -2.77 -3.47 -3.47 -2.08 -3.47 -3.47 -0.63 -0.37 
C | -2.89  1.67 -2.89 -2.89 -1.10  0.29  0.85  0.11 
G |  1.67 -2.20 -0.81  1.61  1.58  0.37 -0.69 -0.12 
T | -3.47 -3.47  1.03 -1.86 -1.67  0.43  0.00  0.27
Fordyce et. al.
ACE2_BFordyce et. al.P = 1.76e-09View matrix ↘
Fisher’s P-value1.76e-09
Information content9.659
Max PWM score9
Recommended cutoff7.91
Position frequency matrix (PFM)
A | 0.23 0.02 0.01 0.01 0.04 0.01 0.01 0.16 
C | 0.20 0.01 0.96 0.01 0.01 0.07 0.25 0.41 
G | 0.18 0.95 0.02 0.07 0.90 0.86 0.26 0.10 
T | 0.39 0.02 0.01 0.91 0.05 0.06 0.49 0.33
Position count matrix (PCM)
A |  23   2   1   1   4   1   1  16 
C |  20   1  96   1   1   7  25  41 
G |  18  95   2   7  90  86  26  10 
T |  39   2   1  91   5   6  49  33
Position weight matrix (PWM)
A | -0.33 -2.77 -3.47 -3.47 -2.08 -3.47 -3.47 -0.69 
C |  0.11 -2.89  1.67 -2.89 -2.89 -0.94  0.33  0.82 
G |  0.00  1.66 -2.20 -0.94  1.61  1.56  0.37 -0.59 
T |  0.20 -2.77 -3.47  1.05 -1.86 -1.67  0.43  0.03
Fordyce et. al.
ACE2_CFordyce et. al.P = 0.0006521View matrix ↘
Fisher’s P-value0.0006521
Information content9.923
Max PWM score8.98
Recommended cutoff4.54
Position frequency matrix (PFM)
A | 0.01 0.02 0.02 0.01 0.16 0.18 0.01 0.01 
C | 0.01 0.01 0.08 0.26 0.38 0.22 0.01 0.96 
G | 0.07 0.95 0.85 0.24 0.12 0.21 0.96 0.01 
T | 0.91 0.02 0.05 0.49 0.34 0.39 0.02 0.02
Position count matrix (PCM)
A |   1   2   2   1  16  18   1   1 
C |   1   1   8  26  38  22   1  96 
G |   7  95  85  24  12  21  96   1 
T |  91   2   5  49  34  39   2   2
Position weight matrix (PWM)
A | -3.47 -2.77 -2.77 -3.47 -0.69 -0.58 -3.47 -3.47 
C | -2.89 -2.89 -0.81  0.37  0.75  0.20 -2.89  1.67 
G | -0.94  1.66  1.55  0.29 -0.41  0.15  1.67 -2.89 
T |  1.05 -2.77 -1.86  0.43  0.06  0.20 -2.77 -2.77
Fordyce et. al.
ACE2Harbison et. al.P = 5.71e-07View matrix ↘
Sequence logo for ACE2
Fisher’s P-value5.71e-07
Information content11.71
Max PWM score9.63
Recommended cutoff5.46
Position frequency matrix (PFM)
A | 0.162 0.015 0.015 0.015 0.015 0.015 0.015 
C | 0.099 0.009 0.961 0.009 0.009 0.009 0.009 
G | 0.099 0.961 0.009 0.009 0.961 0.961 0.009 
T | 0.638 0.015 0.015 0.967 0.015 0.015 0.967
Position count matrix (PCM)
A |  16   1   1   1   1   1   1 
C |   9   0  96   0   0   0   0 
G |   9  96   0   0  96  96   0 
T |  63   1   1  96   1   1  96
Position weight matrix (PWM)
A | -0.68 -3.06 -3.06 -3.06 -3.06 -3.06 -3.06 
C | -0.60 -3.00  1.68 -3.00 -3.00 -3.00 -3.00 
G | -0.60  1.68 -3.00 -3.00  1.68  1.68 -3.00 
T |  0.69 -3.06 -3.06  1.11 -3.06 -3.06  1.11
Harbison et. al.
ACE2Pachkov et alP = 2.93e-08View matrix ↘
Sequence logo for ACE2
Fisher’s P-value2.93e-08
Information content11.98
Max PWM score9.37
Recommended cutoff6.67
Position frequency matrix (PFM)
A | 0.001 0.016 0.001 0.024 0.001 0.053 0.066 
C | 0.007 0.980 0.001 0.001 0.001 0.185 0.141 
G | 0.993 0.001 0.004 0.976 1.000 0.047 0.194 
T | 0.001 0.004 0.996 0.001 0.001 0.715 0.599
Position count matrix (PCM)
A |   0   1   0   2   0   5   6 
C |   0  98   0   0   0  18  14 
G |  99   0   0  97 100   4  19 
T |   0   0  99   0   0  71  59
Position weight matrix (PWM)
A | -5.77 -3.00 -5.77 -2.59 -5.77 -1.80 -1.58 
C | -3.25  1.69 -5.19 -5.19 -5.19  0.03 -0.24 
G |  1.71 -5.19 -3.81  1.69  1.71 -1.34  0.07 
T | -5.77 -4.38  1.14 -5.77 -5.77  0.80  0.63
Pachkov et al
03 / EXPERIMENTAL CONTEXT

Gene-level annotations and interactions.

Genes bound in ChIP-chip experiments 145 genes

YAL040C, YAL062W, YBL023C, YBR057C, YBR157C, YBR158W, YBR159W, YBR162C, YBR162W-A, YBR229C, YBR230C, YDL042C, YDL055C, YDL126C, YDL127W, YDR010C, YDR011W, YDR154C, YDR155C, YDR156W, YDR157W, YDR158W, YDR277C, YDR345C, YEL007W, YER066C-A, YER068W, YER078C, YER079W, YER081W, YER087C-A, YER088C, YER124C, YER125W, YER126C, YER127W, YER177W, YER189W, YER190W, YFL021W, YFL022C, YFL056C, YFL057C, YFR017C, YGL007W, YGL008C, YGL028C, YGL133W, YGL147C, YGL227W, YGL228W, YGL229C, YGR041W, YGR125W, YGR234W, YGR283C, YHL012W, YHL013C, YHL028W, YHL029C, YHR091C, YHR143W, YHR193C, YHR194W, YHR195W, YIL009W, YIR004W, YJL075C, YJL078C, YJL080C, YJL098W, YJL159W, YJL160C, YJR044C, YJR145C, YJR146W, YJR147W, YJR148W, YJR149W, YKL030W, YKL031W, YKL032C, YKL084W, YKL096W-A, YKL097C, YKL142W, YKL146W, YKL148C, YKL150W, YKL151C, YKR040C, YKR042W, YLL019C, YLL020C, YLR207W, YLR255C, YLR256W, YLR256W-A, YLR286C, YLR287C-A, YLR300W, YLR370C, YLR371W, YLR397C, YLR439W, YLR440C, YML003W, YML004C, YML007W, YML008C, YML082W, YML083C, YML100W, YML101C, YML102C-A, YML131W, YMR122C, YMR135W-A, YMR165C, YMR251W-A, YMR261C, YMR262W, YNL078W, YNL079C, YNL098C, YNL154C, YNL241C, YNL327W, YNL328C, YNR018W, YOR138C, YOR140W, YOR315W, YOR344C, YPL018W, YPL019C, YPL024W, YPL025C, YPL056C, YPL230W, YPL251W, YPL253C, YPR105C, YPR106W, YPR115W

Genes affected by TF deletion 264 genes

YCR040W, YER178W, YMR046W-A, YNL016W, YOL013W-A, YOR225W, YOR257W, YBR158W, YDL131W, YFR032C-A, YGL009C, YHR143W, YKL049C, YLR056W, YMR194W, YNL239W, YPR114W, YBR029C, YBR031W, YGR279C, YKR042W, YML113W, YMR011W, YMR013C, YNL078W, YOR226C, YCR097W-A, YBR220C, YDL061C, YGL012W, YGR155W, YGR096W, YHR143W-A, YHR145C, YJL052W, YLR089C, YMR221C, YOR066W, YBR092C, YFR005C, YHR025W, YIR034C, YJR147W, YLR372W, YNL115C, YNL149C, YOL104C, YOR347C, YOR351C, YPL187W, YBR283C, YER026C, YGL105W, YGR180C, YHR208W, YML056C, YMR312W, YBR091C, YBR067C, YDR461W, YFR006W, YHR021C, YLR339C, YNL146W, YNL116W, YOL109W, YOR316C, YBL026W, YCL012W, YCL018W, YDL191W, YDR338C, YER056C, YGL104C, YGR185C, YIL015W, YLR153C, YLR185W, YML055W, YML086C, YDR012W, YGL179C, YIL088C, YLR286C, YLR287C-A, YNL030W, YNR067C, YOR229W, YOR263C, YOR265W, YLR131C, YDL133C-A, YDR224C, YFR044C, YLR439W, YMR230W, YMR173W, YPR147C, YBR009C, YBR011C, YER152C, YER124C, YER154W, YGR285C, YJR025C, YOR230W, YOR264W, YJR148W, YAL012W, YAL043C-A, YDL075W, YKL081W, YLR034C, YDR502C, YFL018C, YGR041W, YLR380W, YOL144W, YPL195W, YBL062W, YBR265W, YGR254W, YGR192C, YJL159W, YKL209C, YKL178C, YML037C, YPL092W, YCR088W, YFL021W, YHR064C, YLL010C, YLR343W, YMR079W, YMR083W, YNL150W, YOL143C, YOR324C, YPL279C, YOR221C, YNR043W, YBL032W, YIL027C, YKL175W, YKL177W, YMR323W, YER060W, YDR086C, YER131W, YHR010W, YKR093W, YPL256C, YIL114C, YBR209W, YKL062W, YLR040C, YLR042C, YOR023C, YOR393W, YPL066W, YCL066W, YCR024C, YGL214W, YHR005C-A, YKR086W, YML126C, YNL035C, YNL066W, YOR210W, YAL022C, YDL081C, YGL028C, YKL120W, YLR041W, YMR173W-A, YOR020C, YPL063W, YCR097W, YFL026W, YHR072W-A, YLR322W, YLR354C, YLR388W, YMR120C, YOL126C, YGL089C, YGR234W, YBR145W, YDR481C, YFL023W, YFR018C, YGR044C, YJR158W, YMR116C, YNL162W, YPL281C, YGR259C, YJR004C, YKL216W, YMR303C, YNR044W, YNR015W, YCR034W, YDR090C, YDR390C, YER170W, YGL225W, YHL004W, YHR018C, YJR046W, YKR035W-A, YLR303W, YMR006C, YNL103W, YPL262W, YBR249C, YEL038W, YGR172C, YGR176W, YHR141C, YJL079C, YLR048W, YLR116W, YML019W, YLR459W, YOR063W, YPL076W, YER136W, YHL003C, YLR302C, YMR064W, YNL070W, YDL121C, YGL032C, YJL078C, YML020W, YMR243C, YMR215W, YBR118W, YBR090C, YKL037W, YJR139C, YKL008C, YLR021W, YLR366W, YMR099C, YOR034C, YCL009C, YDL182W, YDL184C, YJR009C, YKL161C, YKL164C, YLR180W, YML108W, YNL327W, YPL170W, YJL013C, YLR359W, YMR094W, YOL103W, YML081C-A, YNR050C, YOR182C

Genes supported by both experiments 17 genes

YBR158W, YER124C, YFL021W, YGL028C, YGR041W, YGR234W, YHR143W, YJL078C, YJL159W, YJR147W, YJR148W, YKR042W, YLR286C, YLR287C-A, YLR439W, YNL078W, YNL327W